CLUSTAL W(1.81) multiple sequence alignment ENSP00000438262/1-1221 MKTAQALHRMWIQAVKKLRRWKGRVSPSASSPLVFPNLSSWEGEGSKTILTAPGMEELIW ENSMUSP00000097154/1-1167 ------------------------------------------------------MEEVIW ENSRNOP00000062549/1-1164 ------------------------------------------------------MEEVIW ENSCPOP00000020582/1-1150 -------------------------------SIGFPEPENLEFCKSHWLFAAPGMEELKW XP_004838229.1/1-1151 --------------------------MPVRGDRGFPPRRAL----SGWP-RGPGMEELKW ***: * ENSP00000438262/1-1221 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVN ENSMUSP00000097154/1-1167 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVN ENSRNOP00000062549/1-1164 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVN ENSCPOP00000020582/1-1150 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLKENDRVVMVN XP_004838229.1/1-1151 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLKENDRVVMVN **************************************************:********* ENSP00000438262/1-1221 GTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGR ENSMUSP00000097154/1-1167 GTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEVIEEFDGR ENSRNOP00000062549/1-1164 GTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGR ENSCPOP00000020582/1-1150 GTSMEGVLHSFAVQQLRKSGKVAAIVVKRPRIVQVAPLQGSPALSHDDRAFDVMDELDNR XP_004838229.1/1-1151 GTSMEGVLHSFAIQQLRKSGKVAAIVVKRPRIVQGVPLQGSPALSHDDPAFDVMDEFDSR **.**.******:********:********* ** ..**.**.*.:** .*::::*:*.* ENSP00000438262/1-1221 SFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDH ENSMUSP00000097154/1-1167 SFRSGYSERSRHSSHDMLSHSWEGNRERGRPHQRTQSRE----RERSRGRSLERGLDQED ENSRNOP00000062549/1-1164 SFRSGYSERSRHSSHDMLSHSWEDSRERGRPHQRAQSRE----RERSRGRSLERGLDHED ENSCPOP00000020582/1-1150 SYRSGYSERSPHGSREEFHRSWEGSLDRGRGHHRYQD------QDRSRGQSLERGLDRDD XP_004838229.1/1-1151 SVRSGYSERSRPGSREGLNRSWEGSPERGRGYHRD--------QDHSRGQSLERGLNHED * ******** .*: :***.. :*** :.* :::***:******:::. ENSP00000438262/1-1221 -ARTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPE ENSMUSP00000097154/1-1167 YGRSRERSRGRSLERGLDRDF-VSRDHSRGRSIDRDYDRDYERSYHEAYEPDYGGGYSPS ENSRNOP00000062549/1-1164 YGRSHERSRGRSLERGLDRDF-VSRDYSRGRSIDRDYDRDYERSYHQAYEPDYEGRYSPS ENSCPOP00000020582/1-1150 -RRARDRSRGRSSHR-------------------------------PAYGKDSP---SSG XP_004838229.1/1-1151 -RRARDCRRGQSVERYYEQDY----------------ERDYERAYYQAYGLDSP---SGS *::: **:* .* ** * * ENSP00000438262/1-1221 YRRGARHDARSRGPRSRSREHPHSRSPSPEPR------GRP---GPIGVLLMKSRANEEY ENSMUSP00000097154/1-1167 YDRRAHPETRYE--RSRSREHLRSRSPSPESRSRHEHKGQHDPDRPIGVLLTKSKANEEY ENSRNOP00000062549/1-1164 YDRRAHPETRYE--RSRSREHLRSRSPTPESRSRQEHKGQHDPDRPIGVLLTKSKANEEY ENSCPOP00000020582/1-1150 NRRQVQPESRYERPRSRSQEHFQSHSPSPEPR------GQPASDGHIGVLLTKSKANEEY XP_004838229.1/1-1151 SRCRAQQERRYERPRNSSQ----------EPR------GQPDPDRHIGVLLMKNKASEEY .: : * . *. *: *.* *: ***** *.:*.*** ENSP00000438262/1-1221 GLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQL ENSMUSP00000097154/1-1167 GLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQL ENSRNOP00000062549/1-1164 GLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQL ENSCPOP00000020582/1-1150 GLRLGSQIFIKEMTKTGLASKDGNLHEGDLVLKINGTVTENMSLIDAGKLIEKSRGKLQL XP_004838229.1/1-1151 GLRLGSQIFIKEMTKTGLATKDGNLHEGDLILKINGTVTENMSLIDAGKLIEKSRGKLQL *********:****:****:*********::************* ** ************ ENSP00000438262/1-1221 VVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERP ENSMUSP00000097154/1-1167 VVLRDSKQTLINIPALNDSDSEVEDISEIESNRSFSPEERRQQYSDQDYHSSTEKLKERP ENSRNOP00000062549/1-1164 VVLRDSKQTLINIPSLNDSDSEVEDISEIESNRSFSPEERRQQYSDQEYHSSTEKLKERP ENSCPOP00000020582/1-1150 VVFRDSKQTLINIPSLNDSDSELEDISEMESVRSFSPEERRQQVRCYVFYSSPETLT--- XP_004838229.1/1-1151 VVFRDSKQTLVNIPSLNDSDSEIEDISEMGSVRSFSPEERRQQYSDYDYHSSSEKLKERP **:***:***:***:*******:*****: * *********:* ::**.*.*. ENSP00000438262/1-1221 SSREDT-PSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRP ENSMUSP00000097154/1-1167 SSREET-SGRLSRMGATPTPFKSTGDITAAGVTEASREPRYQEEGPVPQPRTAPRVFLRP ENSRNOP00000062549/1-1164 SSREET-SGRMSRMGATPTPFKSTGDITAAGVTEANKEPRSQEESPVPQPRTASRVFLRP ENSCPOP00000020582/1-1150 CSREDAPPGRLSRMGATPTPFKASGD-SAAVATETKKEPRSQEEPPAPLPRTTPRTFLRP XP_004838229.1/1-1151 SSREDTAPGRLSRVGATPTPFKASGD------TETKKEPRYQEEPPAPLPRAAPRAFLRP .***:: ..*:**:********::** .*:.:*** **: *.* *:::.*.**** ENSP00000438262/1-1221 SPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKV ENSMUSP00000097154/1-1167 SPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKV ENSRNOP00000062549/1-1164 SPEDEAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKV ENSCPOP00000020582/1-1150 SPEDEAIYGPDTKMVKFKKGDSVGLRLAGGNDVGLFVAGIQEGTAAEEAGLQEGDQILKV XP_004838229.1/1-1151 SPEDEAIYGPDTKMLRFKKGDSVGLRLAGGNDVGLFVGGIQEGTAAEQAGLQEGDQILKV **********:***::******************:**.******:**: *********** ENSP00000438262/1-1221 NTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKE ENSMUSP00000097154/1-1167 NTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKE ENSRNOP00000062549/1-1164 NTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKE ENSCPOP00000020582/1-1150 NTQDFRGLVREDAVLYLLEIPKGDMVTILVQSRADVYRDILACGRGDSFFIRAHFECEKE XP_004838229.1/1-1151 NTQDFRGMVREDAVLYLLEIPKGEMVTILVQSRADVFRDILACGRGDSFFIRTHFECEKE *******:***************: ****.******:***************:******* ENSP00000438262/1-1221 TPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRDN ENSMUSP00000097154/1-1167 TPQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQREN ENSRNOP00000062549/1-1164 TPQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQREN ENSCPOP00000020582/1-1150 SPQSLAFSRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNRSRAEQMASVQNGQRDN XP_004838229.1/1-1151 TPQSLPFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNGQRDS :****.*:*****************:*****************:***********.**:. ENSP00000438262/1-1221 AGDRADFWRMRGQRS--GVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLF ENSMUSP00000097154/1-1167 AGDRADFWRMRGQRSSGGVKKNLRKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLF ENSRNOP00000062549/1-1164 AGDRADFWRMRGQRS--GVKKNIRKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLF ENSCPOP00000020582/1-1150 AGDRADFWRMRGQRS--GAKKNLRKSREDLTAAVSVSTKFPAYERVLLREAGFKRPVVLF XP_004838229.1/1-1151 AGDRADFWRMRGQRS--GAKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLF *************** *.***:*******:*.***********:*************** ENSP00000438262/1-1221 GPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPK ENSMUSP00000097154/1-1167 GPIADIAMERLATELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPK ENSRNOP00000062549/1-1164 GPIADIAMERLTTELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPK ENSCPOP00000020582/1-1150 GPIADVAMEKLTNELPDLFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPK XP_004838229.1/1-1151 GPIADIAMEKLTNELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPK *****:***:*:.**** ****************:************************* ENSP00000438262/1-1221 AVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTA ENSMUSP00000097154/1-1167 AVDLLNYTQWFPIVIFFNPDSRQGVKTIRQRLSPTSNKSSRKLFDQANKLKKTCSHLFTA ENSRNOP00000062549/1-1164 AVDLLNYTQWFPIVIFFNPDSRQGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTA ENSCPOP00000020582/1-1150 AVDLLNYTQWFPIVIFFNPDSRQGVKIMRQRLNPSSNKSSRKLYDQANKLKKTCAHLFTA XP_004838229.1/1-1151 AVDLLNYTQWFPIVIFFNPESRQGIKMMRQRLNPSSNKSSRKLYDQANKLKKTCAYLFTA *******************:****:* :****.*:********:**********::**** ENSP00000438262/1-1221 TINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDS ENSMUSP00000097154/1-1167 TINVNSANDGWFGSLKDSIQQQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDS ENSRNOP00000062549/1-1164 TINVNSANDGWFGSLKDSIQQQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDS ENSCPOP00000020582/1-1150 TINLNSANDSWFGSLKDTIQNQQGQAVWVSEGKIEGMDDDPDDHMSYLTALGADYLSCDS XP_004838229.1/1-1151 TINLNSANDSWFGTLKDTIQNQQGQAVWVSEAKMEGMDDDPDDHMSYLTALGADYLSCDS ***:*****.***:***:**:**.:******.*:******.:*:******:********* ENSP00000438262/1-1221 RLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRA ENSMUSP00000097154/1-1167 RLISDFEDTDGEGGAYTDNELEEPAEEPLVSSITRSSEPVQHEENIRKSSPEPRAQMRRA ENSRNOP00000062549/1-1164 RLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRA ENSCPOP00000020582/1-1150 RLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKLSPEPPAQMRRA XP_004838229.1/1-1151 RLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKLSSDPPAQMRRA *********************:**********************.*** *.:* ****** ENSP00000438262/1-1221 ASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYP ENSMUSP00000097154/1-1167 ASRDQLRDASPPPAFKPEPPKARSQNREDSFDYS-----KSNLPATAGSEIPGGSTKGYP ENSRNOP00000062549/1-1164 ASRDQLRDGSPPPAFKPEPPKVRNQNREDSFNYS-----KSNLSAMAGSEIPGGSTKGCP ENSCPOP00000020582/1-1150 ASRDQLRDSSPPPAFKPEPPKIKPQNREESYDFSKSQEYKSNPSAMGGDDFPRTTARGCP XP_004838229.1/1-1151 ASRDQLRDSSPPPAFKPEPPKAKTQSREESCDFSKSQEYKSNPSTMGGNEIPGTAGKGCP ** ***** ************ : *.:*:* ::* *** .: .*.: * : :* * ENSP00000438262/1-1221 PPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQR ENSMUSP00000097154/1-1167 PPIAAKPAFGRPILKPSTPVPMPESEEVGESTEEQEDAPRSVLGRVKIFEKMDHKAKLQR ENSRNOP00000062549/1-1164 PPIAVKPAFGRSILKPSTPVPMPESEEVGESTEEQEEAPKSVLGRVKIFEKMDHKAKLQR ENSCPOP00000020582/1-1150 PPVAAKPSFGRSVQKPSVPVPAPESEEVEERIEDQENAPKSVLGKVKIFEKMDHKARLQR XP_004838229.1/1-1151 PPVAAKPSFGRSFQKPSISSPPPESEELRENSQEQEDTPKSVLGKVKIFEKMDHKARLQR **:*.**:***.. *** . * *.**: * ::*:::*:****:***********:*** ENSP00000438262/1-1221 MQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGS ENSMUSP00000097154/1-1167 MQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPPHMSSRPPEPQKAPSRLYQDTRGS ENSRNOP00000062549/1-1164 MQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPQHM--RPPEPQKAPSRLYQDTRGS ENSCPOP00000020582/1-1150 LQELQEAQNAQIEIAQKHPSIYAVPIKAPKPDAGLPQHTSSRPPEPQKGPSRFSQNMHGS XP_004838229.1/1-1151 MQELQEAQNAQIEIAQKHPSLYAVPIKTPKPDAGLSQHTSSRPPEPQKGPSRPYQNMQGN :*********:********.:******: ***.* . * *******.*** *: :*. ENSP00000438262/1-1221 YGSDA-EEEEYRQQLSEHSKRGYYGQSARYRDTEL ENSMUSP00000097154/1-1167 YGSDP-EEEEYRQQLAAHSKRGYYSQPSRYRDTEL ENSRNOP00000062549/1-1164 YGSDPEEEEEYRQQLAAHSKRGYYSQPSRYRDTEL ENSCPOP00000020582/1-1150 YGSDA-EEEEYRQQLAEHSKRSYFGQPAKYRDTEL XP_004838229.1/1-1151 YGSDA-EEEEYRQQLAEHSKRSYYSQPARYRDTEL ****. *********: ****.*:.*.::******