CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000020000/1-1538 -----------------TICQKHGLPFEAVDLRWGLRNSEAAEQLTVDLCLEELERCQRT XP_004873323.1/1-1559 -MRRGRPCWGPPAPSCXTFCRNQGLPFEAVDLRWGVQDSEAADQLTPDLCLEELQRCQRT ENSP00000447224/1-1564 -MQRGKPCRALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKT ENSMUSP00000091135/1-1563 MDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKT ENSRNOP00000064974/1-1384 ------------------------------------------------------------ ENSCPOP00000020000/1-1538 SLGPAFVALVGDQYGPCPVPRRIEEKEWEVLRAQLSTRPRDLELLIRCFRRDENSVPPSY XP_004873323.1/1-1559 SLGPAFVALVGDQYGPCPVPRRIEEKEWEALRAQLSTRPGDLELVAQRFRRDENSVPPSY ENSP00000447224/1-1564 SIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTY ENSMUSP00000091135/1-1563 SIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTY ENSRNOP00000064974/1-1384 ------------------------------------------------------------ ENSCPOP00000020000/1-1538 VLQAVGNEEATGPDEPTLTSALRTAAQEAQRLGLISQEQWQRYHHSGLQWELELGLLS-- XP_004873323.1/1-1559 VLQAAGGGEAPGPEEPTLASVLRAAAQEARGRGLISQEQWQRYHRSVLEWELERGLLS-- ENSP00000447224/1-1564 VLQAPGTGEACEPEEATLTSVLRSGAQEARRLGLITQEQWQHYHRSVIEWEIERSLLSSE ENSMUSP00000091135/1-1563 VLQPSGSLVVPGPEEATLTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGLLSSA ENSRNOP00000064974/1-1384 ----------------------------------------------VIEWEIEHGLLNSA ::**:* .**. ENSCPOP00000020000/1-1538 -GAPGAMAFLREIPELDRHLLQDCALAVVDRLPDGCVDVAAQDVLSGLKQRMTQERPGAL XP_004873323.1/1-1559 -GSPGATVFLREIPELARHLLQDCALPVVDRLPDGLVDTTAQGHLSSLKQRMAQEWPGVL ENSP00000447224/1-1564 DREQGATVFLREIQDLHKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVL ENSMUSP00000091135/1-1563 RGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGAL ENSRNOP00000064974/1-1384 RGDQGATVFLRDVQDLSKHILDDCCLKMVDRLADGCLDTNAQSLLSGLKGRILDAQPGAL ** .***:: :* :*:*:**.* :**** ** :*. **. **.** :: : **.* ENSCPOP00000020000/1-1538 RVLRLPWARDLVNPKNKAHACYLHELGEQFVKGASLQLLQRLRELPPNPPGPARLFEDIR XP_004873323.1/1-1559 KVHRLPWARDLVNPRNKAHARYLLELGEQFVASAAHQVLQRLRELPPALPSPAWLFQDIR ENSP00000447224/1-1564 KTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIR ENSMUSP00000091135/1-1563 KSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIR ENSRNOP00000064974/1-1384 KSHHLPWSRDLVNPKNKTHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIR : :*.*:******:**:** ** :*.**** : *:* :**** . *:::** ENSCPOP00000020000/1-1538 HHLWQGAQATRTFIGRQELLVRLGQRLRQDDGHSHGPLVLGGTPGVGKTTVLCKLAEQAA XP_004873323.1/1-1559 HHLWQGTEATRAFCGRQGLLGRLGQRLRQDDGCPHSPLVLFGPPGIGKTAVLCKLAEQAA ENSP00000447224/1-1564 HHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMP ENSMUSP00000091135/1-1563 HHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVP ENSRNOP00000064974/1-1384 HHLWQSTESTKVFCGHQELLAQLKQRLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVP *****.:: :.* *:* ** :* *:**:*:. * **** *.**:***:::****:* . ENSCPOP00000020000/1-1538 GLLGRKTVTVLRLLGTSQGSSDARGLLAGLCLQLCLAFGLPTPPSQVLQAHARLAHFFHV XP_004873323.1/1-1559 GLLGRKTVTVLRLLGTSQGSADARGLLAGLCLQLCLAFGLPAPPPQVLQARTRLAHFFHV ENSP00000447224/1-1564 RLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQVCLAYGLPLPPAQVLDAHTRVVQFFHT ENSMUSP00000091135/1-1563 ELLGHKTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLPLPPAQVLEAHSRVGHFFHT ENSRNOP00000064974/1-1384 ELLGHKTVAVLRLLGTSKLSLDARSLLRSLSFQLCLAYGLPLPPAQVLEAHSRVGHFFHI ***:***.********: * ***.** .:.:*:***:*** **.***:*::*: :*** ENSCPOP00000020000/1-1538 LLHTVSRRNFESLVILLDAVDDLDPGHPAQAIPWLPVVCPPRVHLILSACSGWHGALDA- XP_004873323.1/1-1559 LLHTVARRDFESLVILLDAVDDLDPGRRSGAIPWLPLACPPRVHLILSACSGPCGALHAV ENSP00000447224/1-1564 LLHTVSCRNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTL ENSMUSP00000091135/1-1563 LLHTVSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQ-VLHNL ENSRNOP00000064974/1-1384 LLHTVSQRNFESLVLLLDSVDDLDSIRHTPRVSWLPLKCPPRVHLILSACSGQQ-VLCNL *****: *:*****:***::****. : :.***: **********:*** .* ENSCPOP00000020000/1-1538 ----QDQDACWEVGPLPVDQGQKMVQRLLAEAGRTLSPAQHDMLWASLPECGHPGRLWLA XP_004873323.1/1-1559 RATLRDSDAYWEVEPLSEDQAQEMVQLLLAAAGRTLSPAQRNLLWASLPEAGNPGRLQLA ENSP00000447224/1-1564 QRVLLDPEAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLA ENSMUSP00000091135/1-1563 QQTLKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLA ENSRNOP00000064974/1-1384 QQTLKDPSAYWEVKALSGSQGQEFIQLLLAAERRMLSPGQRDVLWASLPECGHPGRLRLA * .: *** .*. .*.*:::* *** * *** : ::*******.*:**** ** ENSCPOP00000020000/1-1538 FHEAHSWASFSVPWPLAATAEEATHQLCARLELTHGQLLVAHVLGYLAASRHGLSEAELK XP_004873323.1/1-1559 FHEAHTWASFSVPVPLATTAEEATHQLCARLELTHSWLLVAHVLGYIEASRHGLAEAELK ENSP00000447224/1-1564 FEEARKWASFTVPVPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELK ENSMUSP00000091135/1-1563 FEEARKWASFTVPVPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRYGLSEAELK ENSRNOP00000064974/1-1384 FEEARKWASFTVPVPLATTAEEATHQFCIRLEETHGQLLVARVLGYIVSSRYGLSEAELK *.**:.****:** ***:********:* *** **. ****:****: :**:**:***** ENSCPOP00000020000/1-1538 DVLSLDDEALLAAYRDWTPPSQEMLRFPPLLWVRLRQDLGHYLVQRPMHGTTLLAIAHRQ XP_004873323.1/1-1559 DVLSLDDEVLQAAYRAWTPPSRELLRFPPLLWVRLRRDLDHCLSRRPMHGTTLLAIAHRQ ENSP00000447224/1-1564 DVLSLDDEVLQDVYRDWTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQ ENSMUSP00000091135/1-1563 DVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQ ENSRNOP00000064974/1-1384 DVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCILLAIAHRQ ********.* .** *****:*:************:**.: * :**:.* ******** ENSCPOP00000020000/1-1538 LAEVVQARYLSPAKAAARHHVLADFFSGAWSQGTKKHITLLCVGRPQSLDRKVAPQPLWF XP_004873323.1/1-1559 LAQVVRERYLSPPEAAARHSVLADFFAGTWSQGTKKLITLPRVGGPLSLDRKVAPQPLWF ENSP00000447224/1-1564 LVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAPQPLWF ENSMUSP00000091135/1-1563 LSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWF ENSRNOP00000064974/1-1384 LSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWF * :*:: **** .: * ** ***:**:*:**** ** *** ** * .************ ENSCPOP00000020000/1-1538 SDSVANERKLAELPYHLLGAGRKEELLRDVLGDMSWLSCRVLSGGLDALLDDVDLCMPHV XP_004873323.1/1-1559 SDSVANERKLAELPLHLLHAGRTRELLQDVLGDMSWLSCRLLSGGLDALLDDVDLCVPHV ENSP00000447224/1-1564 SHTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHL ENSMUSP00000091135/1-1563 SSTVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHM ENSRNOP00000064974/1-1384 SGTVANWRKLTELPFHLLHAGCLEELKQEVLGNMSWISCRGISGGIEDLLDDFDMCAPHM * :*** *** *** *** :* .** ::***.***:*** :***:: ****.*:* **: ENSCPOP00000020000/1-1538 DGPELGLVRETLELCRPALELRGAEKSVLYTELLARLQASAPLYPVLVGPLCQQAQAWLH XP_004873323.1/1-1559 DSPELGLLREALELCRPALELRGTERSVLYVELLARLQAFAASCPVLLGPLSQQAQAWLR ENSP00000447224/1-1564 DSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQ ENSMUSP00000091135/1-1563 NSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFR ENSRNOP00000064974/1-1384 DSPEVYLVREAIQLCRPAVELRGLGQAMLFTGLHCKLTFHQPTHPSITGP---------- :.**: *:**:::** **:**** :::*:. * .:* . * : * ENSCPOP00000020000/1-1538 ACPFPLLVPLAGCLTPPGGPLYATLTGCHRGVTALAWSPEEQRLVVGAQDGMVTVWDVQK XP_004873323.1/1-1559 ACPHPVLVPLAPCLQPPGGPLCTSLTGCHRGVTALAWSPQERLLVVGAQDGMVTVWDVEE ENSP00000447224/1-1564 LCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEE ENSMUSP00000091135/1-1563 ACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEE ENSRNOP00000064974/1-1384 -SAHPPIHRNLYSLSPSPGP-GSFLLGCFWAPSLNLKALHTSCKLSETQSHFSVILEAEA ...* : * *. ** : * **. . : . . : :*. .: : : ENSCPOP00000020000/1-1538 QRVSYVLMGHTGEVMCVAVLARGTLAISASRDRSLCLWHLLSGRERWTQRDVGLPDS--- XP_004873323.1/1-1559 ARVTHILTGHAGEVTCLAVLAREALAVSASRDRTLCLWHLLSGRERFTLRDTGTPDP--- ENSP00000447224/1-1564 QHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEP ENSMUSP00000091135/1-1563 QQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEP ENSRNOP00000064974/1-1384 NILFHTLS-TAAEVRCVRVFAQGTLAISASKDHTLRLWSLLSGQEKATILDGGSPNPTEQ : : * :.** *: ::*: :** ***:* :* ** ****:*: * * * :. ENSCPOP00000020000/1-1538 QPFSLCVDEVHGVVYAAWGSQVSAWSLQTSELVFRILGDTANPCVCTAVLVSRARLLTLS XP_004873323.1/1-1559 QTCRLHLDEAQGVVYAAWSSQISAWNLQTAELLFRILGDVSDPWVYTAVLVSQAQLLTLS ENSP00000447224/1-1564 QIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVS ENSMUSP00000091135/1-1563 QSWDLHVDERNNVVYSTSGARINMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALS ENSRNOP00000064974/1-1384 QGWDLHVXXRTGLLHATWFTGINVWDLETSKLVFCITGDASDPWVCVALLAAQGLLLALT * * : ::::: : :. *.*:*:: :* * **.::* : *:*.::. **::: ENSCPOP00000020000/1-1538 KSGAVSMWSSATGQLQGTWSLSTTPEETLTCVVPIQQQGRVIAGFRSGSLTVVSPDGVHR XP_004873323.1/1-1559 KGGAISVRSSATGQLQGTRPLSSTPEETPSCAVLVQKQGRLIAGFSSGSIAVVSPDGDHG ENSP00000447224/1-1564 RDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKG--- ENSMUSP00000091135/1-1563 KGGQVSLWSSAMGKLQEKHQLSSIKEETPTCAVSIQSRARLVAGFSSGSIALVSAGE--- ENSRNOP00000064974/1-1384 EGGQVSLWSSAVGKLQEKHQLCSIKEETPTCAVSIQTRARLVVGFSSGSVALVCAGE--- ..* :*: *** *:** . :.: *** :*.* :* :.:::.** .**:::*.. ENSCPOP00000020000/1-1538 DRLLDRLPEAPRFLVLAEDESLLAAGFGTRVRVFLADSEGFHRFPAADLEHEDVVETAVF XP_004873323.1/1-1559 DQQLERLPEAVCFLVLAEDESLLAAGFGRCVRTFLADSQAFRQFLATDLEHEDTVETSVF ENSP00000447224/1-1564 DRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVF ENSMUSP00000091135/1-1563 DRLLEKLPEAVGFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVETAVL ENSRNOP00000064974/1-1384 DRLLEKLPEAVGFLAVSEDDSLLAVGFGRCVRVFLADSQDFHRFMATDLEHEDVVETAVL *: *::**:* **.::**:***..*** ** *****. *::* * ****** ***:*: ENSCPOP00000020000/1-1538 GLQNNLLVTGSQDGLVQVWSLSEQGVLLDVLESTGGPVNLLVHAGTLVASASRQSSSLRV XP_004873323.1/1-1559 GPQNNLIVTGSRDALVQVWSLSEQGTLLHVLEGVGGPGSLLARAGALVACASQQSSSLRV ENSP00000447224/1-1564 GTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKV ENSMUSP00000091135/1-1563 GPENNLIITGSRDALIQVWSLSEQGTLLNVLEGVGAPVSLLVRGGTLVVSASRKSSSFKV ENSRNOP00000064974/1-1384 GPENNLIITASRDALIQVWSLSEQGTLLSVFESAGAPASLLVLCETLVVSASWKSSSFKA * :***::*.* *.*:*********.** ::*..*.* .**. :**..** :***::. ENSCPOP00000020000/1-1538 WDLSNLQQPRHPVAFLDRTGLAAVSHHGRYVYFPKVGDKSKITVWDVAEGEVQDVLDVSS XP_004873323.1/1-1559 WDLSSPQRPQPPAPFPDRAGLVALSHHGSFVYFPKVGDKHKVTVWDVAEGEVQDTLDASS ENSP00000447224/1-1564 WDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSS ENSMUSP00000091135/1-1563 WDLKSTKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGDKNKVTIWDLAEGEEQDCLDTSN ENSRNOP00000064974/1-1384 WDLRSTQKPPSPTPFLDRTGLATVSHHGSYVYFPKVGDKNKVTIWDLAEGEEQDSLDTSN *** . :: *..* **:**.::**:* :*****:*** *:*:**:**** ** **.*. ENSCPOP00000020000/1-1538 EVRCLEVAEGPKLLLAGLASGAMLGFPLDARQDVLCVPPPEAHKPVVGMALSKREDRLAI XP_004873323.1/1-1559 EVRCLEVAEGPKLLFAGLSSGAVLVFPLDSRQDVLCVPPPEARKPVVCMALSKLEDRLAI ENSP00000447224/1-1564 EIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAI ENSMUSP00000091135/1-1563 EVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSLSKSENRLAI ENSRNOP00000064974/1-1384 EVCCLEVAEQTKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSVSKSEDRLAI *: ****** ***::** ** :* ***::****:*:*****:*.: *::** *:**** ENSCPOP00000020000/1-1538 AYDNIVLVLDVVPGDPCPAIEGPVCIFYTQLPETVTSVAVLDDCRVLYGMTSGNLFLYAC XP_004873323.1/1-1559 AYDNTVLVLDVEPGDPCPAIEGPAYTFYTQLPETIASVAVLGDHRVLYGMTSGDLFLYAC ENSP00000447224/1-1564 AYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYEC ENSMUSP00000091135/1-1563 AYDNIVLVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADYRVVYGMSDGSLFLYDC ENSRNOP00000064974/1-1384 AYDNIVLVLDISPGDLCPAIEGPTYTFYTQLPETIVRVAVLADYRVVYGMSDGSLFLYDC **** *****: .** **.*:** ********: **:* * **:*.*:.*.**** * ENSCPOP00000020000/1-1538 TNSQVFPLEAHGSPITCVDVSHSELLAVSGSQEGRLCLWDLRACECRLELDHVSSYCPGV XP_004873323.1/1-1559 SDSQVFPLEAHSSRVTCVDVSHSEQLAVSGSQEGRLCLWDVGTCACRLELGYTSSYCPGV ENSP00000447224/1-1564 ATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGV ENSMUSP00000091135/1-1563 ACSKVFPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQACRGMFEMSYENSCCRGV ENSRNOP00000064974/1-1384 AQSKVFPLEAHGSRVSCVEVSHREQLAVSGAEDALLCLWDLQACREKFKMSYESSYCRGV : *:.****:* * ::**:*** * *.***:::. *****: : :::.: .* * ** ENSCPOP00000020000/1-1538 RCACFSKDDKYVFSGLEDRSVIVWSVLDAGTLLASQFVHAVVTRIIPTSNGFIAPTSHGY XP_004873323.1/1-1559 RCVCFSKDDKYVFSGLQDRSVIVWSAVD-GTLLATQFVHAVVTRIIPTSNGFIAPTSHGY ENSP00000447224/1-1564 QCACFSKDDKYVYVGLKDRSILVWSVLD-GTLLTVQFVHAVVNRIIPTTSGFIAPTRHGY ENSMUSP00000091135/1-1563 RCACFSRDDKHVFAGMEDRSVTAWSTVD-GTLLAVQFVHAVINRIIPTSNGFMAPTSHGY ENSRNOP00000064974/1-1384 RCACFSKDDKHVFTGMEDRSIIAWSALD-GTLLAVQFVHAVVNRIIPTSNGFMAPTSHGY :*.***:***:*: *::***: .**.:* ****: ******:.*****:.**:*** *** ENSCPOP00000020000/1-1538 ILRQRFQCPASWASQQYPLRNFQKAVWRVKCRQRQEL--AAGALQDS-SEGAQGRKPKPN XP_004873323.1/1-1559 ILRNRFQCPASRASQQDPLRNFQKAVWRVKWRQREEL--AAGAPQDSESEAAQGREAKHN ENSP00000447224/1-1564 LIRENFQCLSAKASPQDPLKNFKKAMWMVKSRQREELVAAAGAPQDLESESAQGNETKSN ENSMUSP00000091135/1-1563 LIRERFQCPSVRASQQDPLKNFKKAVWLVKTRQREEL-AAAEASQDAEPVAVEGKESKSN ENSRNOP00000064974/1-1384 LIRERFQCPSARASQQDPLKNFKKAVWLIKTRQREDL-AEAEAPQDAEPVAVEGKESKSN ::*:.*** : ** * **:**:**:* :* ***::* * * ** . ..:*.:.* * ENSCPOP00000020000/1-1538 KRSQVCLIV XP_004873323.1/1-1559 KRSQVCRIV ENSP00000447224/1-1564 KCSQVCLIV ENSMUSP00000091135/1-1563 KRSQVCLIL ENSRNOP00000064974/1-1384 KHSQVCLIL * **** *: