CLUSTAL W(1.81) multiple sequence alignment ENSP00000427567/1-1143 MHVMNCVSLVSDKENGNIATAPGFMIGQTPPPAPPPPPPPPPPSP-PCSCSREECPSSPP ENSMUSP00000088525/1-1149 MHVMNCVSLASDKENGTLATAAAFMTGQTSPSASPPPPPPPPPPP-PCPHSGEGFSPSPP ENSRNOP00000060810/1-1148 MHVMNCVSLAGDKENGTLATAAAFMTGQTSPSASPAPPPPPPPPP-PCPHSGEGFPPSPP ENSCPOP00000018374/1-989 MRVMNCVSLASDKGNGNIAAAAGFMIGQTTP----------------------------- XP_004869280.1/1-1066 MHVMNCVSLASDKENGNIATAAGFMIGQTSPPSPPSPPPPPPPPPLPCPCSGGDGPPSAP *:*******..** **.:*:*..** ***.* ENSP00000427567/1-1143 PPPPPPLPGEPPI-PPPPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWT ENSMUSP00000088525/1-1149 PPLPPPLPGGPPIPPPPPPGLPSVSYLNGYSSLGKKKRMRSFFWKTIPEEQVRGKTNIWT ENSRNOP00000060810/1-1148 PPLPPPLPGGPPV-PPPPPGLPPASYLNGYSSLGKKKRMRSFFWKTIPEEQVRGKTNIWT ENSCPOP00000018374/1-989 -------------------------HLDTFGSLGKKKRMRSFFWSTIPEEQVRGKANIWT XP_004869280.1/1-1066 PPPPPPLPWG----PPPSAGQPLAPQENSFGSLGKKKRMRSFYWNTIPEEQVRGKTNIWT : :. **********:*.**********:**** ENSP00000427567/1-1143 LAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNI ENSMUSP00000088525/1-1149 LAAKQQHQYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSFRDAREEVTVLDAKRSMNI ENSRNOP00000060810/1-1148 LAAKQQHHYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSFRDAREEIAVLDAKRSMNI ENSCPOP00000018374/1-989 LGAGGQHHFQIDTKTIEELFGQQEDTPRPSLPKRGGPLSSSFKDMREEITILDAKRNMNI XP_004869280.1/1-1066 LAGREQHHFQIDTKSIEELFGQQEDIAKASVPKRGGTLNSSFRDAREEITILDAKRNMNI *.. :*::***.*:********** .:.*:*:** .*.***:: ***:::*****.*** ENSP00000427567/1-1143 GIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLA ENSMUSP00000088525/1-1149 GIFLKQFKKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKAFNGDVSKLSLA ENSRNOP00000060810/1-1148 GIFLKQFKKSPQSIVEDIHQGRSEHYGSETLREILKLLPESEEVKKLKTFNGDVSKLSLA ENSCPOP00000018374/1-989 GIFLKQFKKSPQCIVEDIHQGKSEEYGSETLREFLKLLPKSEEVKKLKAFSGDVAKLSLA XP_004869280.1/1-1066 GIFLKQFKKSPRSIVEDIHQGKSENYGLETLGEFLKILPESEEVKKLKTFSGDVSKLSLA ***********:.*****:**:**.** *** *:**:**:********:*.***:***** ENSP00000427567/1-1143 DSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLV ENSMUSP00000088525/1-1149 DSFLHCLIQVPNYSLRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLV ENSRNOP00000060810/1-1148 DSFLYCLIQVPNYSLRIEAMVLKKEFLPFCTSLYKDITTLRAAMKELMLCEELHSILHLV ENSCPOP00000018374/1-989 DSFMHRLIQVPNYSLRIEAMVLKKEFLHACSSLYTDITILRSATKELMSCEALHSILHLV XP_004869280.1/1-1066 DSFLHCLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITSLRSAIKELISCEELHAILHLV ***:: ********************* *:**:.** **:* ***: ** **:***** ENSP00000427567/1-1143 LQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEK ENSMUSP00000088525/1-1149 LQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAILLNFSEK ENSRNOP00000060810/1-1148 LQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKHNTILLNFSEK ENSCPOP00000018374/1-989 LQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDSILLHFSGK XP_004869280.1/1-1066 LQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEK *************************************************:::***:** * ENSP00000427567/1-1143 LHHVQKTARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECW ENSMUSP00000088525/1-1149 LQHVQETSRLSLDITEAELHSLFVRTKSLQENIQLDQELCQQMEDFLQFAVEKLAELELW ENSRNOP00000060810/1-1148 LQQVQETSRLSLDIIEAELHSLFVRTKSLRENIQRDQELRQQMEDFLQFAVEKLAELELW ENSCPOP00000018374/1-989 LCHVQEASRLSLDNTEAELKSLTLRTKSLEENIKRDGELYQQMADFLQCATAKLVDLEQW XP_004869280.1/1-1066 LSHVQEAARLSLDNTEAELKSLVVRTRSLKENIKPDVELCQQMEDFLQFATEKLADLEQW * :**:::****: ****: * :**:**.***: * ** *** **** * ** :** * ENSP00000427567/1-1143 KQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLK ENSMUSP00000088525/1-1149 KRELQGEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRQK ENSRNOP00000060810/1-1148 KRELQVEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRLK ENSCPOP00000018374/1-989 KEKLQSEAHTLIDFFCEDKETMTLDECLQIFRDFCTKFNKAVKDNQEREVQESRQQQRLR XP_004869280.1/1-1066 KQKLQREAHTLIDFFCEDKGTMKLDECLQIFRDFCTKFNKAVKDNREREAQESRQLQRLK *.:** **:********** **.****:********:********::** ** :* ** : ENSP00000427567/1-1143 EQEQKQRSWATGELGAFGRSSSENDVELLTKKGAEGLLPFLHPRPISPSSPSYRPPNTRR ENSMUSP00000088525/1-1149 EMEQKRYSWSTGELGSFGRSSSENDVQMLAKTGTEDLPSFLKPRPNS---PSYRPPNTRR ENSRNOP00000060810/1-1148 ELEQKRHSWTTGELGGFGRSSSENDVQMLAKKGTEDLPSFLKPRPNS---PSYRPPNTRR ENSCPOP00000018374/1-989 ALEEKQHSWAAGELGGFIRSSSETDMQLLTHKGTEDLALFLHPRPDS---PSARPPNTRR XP_004869280.1/1-1066 ATEERRHHWAAAELGAFGRSSSENDVELLTNKGAEDQAPFLRPGTES---SSSRPPNTLR *::: *::.***.* *****.*:::*::.*:*. **:* . * .* ***** * ENSP00000427567/1-1143 SRLSLGPSADRELLTFLE-SSTGSPEEPNKFHSLPRSSPRQARPTIACLEPAEVRHQDSS ENSMUSP00000088525/1-1149 SRLSLGISADRELLTFLE-SATSSPEDPNKFNSLPRSSPRQARPTIAWMEPREQQSHGPN ENSRNOP00000060810/1-1148 SRLSLGISADRELLTFLE-SATSSPEDPNKFNSLPRSSPRQTRPTIAWMEPREQETHGPV ENSCPOP00000018374/1-989 SRHSLGFSADRELLSFLE-SATGGLEEPK-FNTLPGRGRRLARPTLASMQPGGAGDCHPT XP_004869280.1/1-1066 SRHSLGISAERELLTFLERATTGCPEEPK-FNSLPRSRARQARPAVARMQPGEAGDRHLP ** *** **:****:*** ::*. *:*: *::** * :**::* ::* ENSP00000427567/1-1143 FAHKPQAS-GGQEEAPNPPSAQAHQLAAAQPENHASAFPRARRQGVSVLRKRYSEPVSLG ENSMUSP00000088525/1-1149 FTHEPQAS-KIQEKAPPP--AWQNQLPTTWREEPASPLPLAGRSR-PSLRKRNSEPVGLG ENSRNOP00000060810/1-1148 FTHDPQAS-KNQEQTPHP--AWQNHLPPSWLGEPVSPSPPAGRSR-PSLRKRSSEPVGLG ENSCPOP00000018374/1-989 SPHRPPKA----PDVPQP-------------AEQTGAVPRAWHQA-GGLQKRSSEPGGLG XP_004869280.1/1-1066 SVHRPQASPAGPERVPEPPCPWRGQPPPG-PEEQASAVPRARRGGLGALQKRNSEPAGLG * * : .* * : ... * * : *:** *** .** ENSP00000427567/1-1143 SAQSPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQLTLSDFSPMELESVGHRGPQS ENSMUSP00000088525/1-1149 PTQSPPLLPLDLGVREHELVTGLTQFDLQSPKSLEEGSQLTLNDFCPTKLPSPGDRSSQP ENSRNOP00000060810/1-1148 TAQSPPLLPLDLGIREHELVTGLTQFDLQSPKSLEETSQLTLNDFCPTKLPPLGDKSSQP ENSCPOP00000018374/1-989 AAGSPPLPSLALGVKEHELVTGLARFSLGDPKGSQETALNTPNEV----IPGPGSPRSPS XP_004869280.1/1-1066 PAGTPALPSLALGVQEHELVAGLAQFSLEDPKGRQQPARLAQRDAGPGASPGPGTPPAP- .: :*.* .* **::*****:**::*.* ..:. :: : : : * . ENSP00000427567/1-1143 LSASSSSLTPMGRDALGSLSPALEDGKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDT ENSMUSP00000088525/1-1149 FAAGGDSLPPKDTDTQEVLSPAGEDDRTISDEPSSEALVSVVVTDTEDKDAGPLLYVSDT ENSRNOP00000060810/1-1148 FDAGGDSRAPKDTDPREALSPAGEDDRAISDEPSSEALVSVVVTDTEDKDPGSLLYVSDT ENSCPOP00000018374/1-989 YST-----TAADKGPREAPSQAPEAEAATPHEPGSQALGPAGSGDLEHGDH---LSVSDA XP_004869280.1/1-1066 -SAGSDRVTPVSSGPQEGPGPAPEADTA---EPGGKASGSVGSGAPEDGDPGP-CHVSDT : .. . .. . * * : **.. * .. *. * :**: ENSP00000427567/1-1143 TDCSLTLDCSEGTDSRPRGGDPEEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPV ENSMUSP00000088525/1-1149 TDCSLTLDCSEGMDSRAGGDKQEEEKEGDGSVSSGAGEAGSSQVSSNSVSSPPGEVPAPK ENSRNOP00000060810/1-1148 TDCSLTLDCSEGTDSRPGGDKHREEKEGDGSVSSGAGEAGSSQVSSNPASSPPGEVPAPK ENSCPOP00000018374/1-989 TDCSLTLDCSEES-SEPGRLEDGAWPEAEGR----------SPASPMPASS---EASATD XP_004869280.1/1-1066 TDCSLSLDCSEGVEPRPGGARPG---EDTGA----------LQASPLPASSPAGEAPAPD *****:***** ... * * .*. ..** *..*. ENSP00000427567/1-1143 SVDSEPSCKGGLPRDKPTKRKDVVAPKRGSLKEASPGASKPGSARRSQGAVAKSVRTLTA ENSMUSP00000088525/1-1149 SSKSELSCQGGLPKDRPSRGKDAIAPKRNSFKEASVGASKPVSARRSQGVTTKPVRTLNS ENSRNOP00000060810/1-1148 STKSEPSCQGGLQKDRPSRGKDAMAPKRNSFKEASVGASKPVSARRSQGVAPKPVRTLNS ENSCPOP00000018374/1-989 SAPSEPGRKGGRARDRPAPAKEAPVPRRGSGREAP--RERPGGGRRGQGTEPRPVRTLTA XP_004869280.1/1-1066 SVKSEPACKAGLARDRLAKGKEASVPKRSSLREAPPGTAKPGSARRSAGTATKPVRTLTA * ** . :.* :*: : *:. .*:*.* :**. :* ..**. *. .:.****.: ENSP00000427567/1-1143 SENESMRKVMPITKSSRGAG-WRRPELSS-RGPSQNPPSSTDTVWSRQNSVRRAS----- ENSMUSP00000088525/1-1149 SENEHMRKVVPISKSSRGAGPWKRPEPTP-KATPRETPSSTDTPLSRRSSVRGTSDTSPR ENSRNOP00000060810/1-1148 SENEHMRKVVPISKSSRGAGPWKRPELTS-RATPRETPSSTDTQLSRRSSVRGTSDTSPR ENSCPOP00000018374/1-989 SESQGLRKVVPLAKGGRGARAGKTPEPPPARNPPREAAP------ARSGSLKGTQD---- XP_004869280.1/1-1066 SESQSMRKVVPISKAGRAPS---------------------------------------- **.: :***:*::*..*.. ENSP00000427567/1-1143 ------TGAEEQRLPRGSSGSSSTRPGRDVPLQPRGSFKKPSAKPLRNLPRQKPEENKTC ENSMUSP00000088525/1-1149 RPQVSGSGAEEPRLPR-SSGSISGRPGKDAPLQPRASFRKPSAKPLRNIPRQKPEENKVS ENSRNOP00000060810/1-1148 RPQVSGSGTEEPRLPR-SSGSIGGRPGKDPTLQPRASFRKPSAKPLRNIPRQKPEENKVS ENSCPOP00000018374/1-989 ------AGPEEQRVPR---GGGNARPGKESPLQPKGSVRKPSAKPLRSVPS--------- XP_004869280.1/1-1066 ------AGTEDQRPTR---GSGGARPGKEAALQPKGSLRKPSAKPLRNVPRPKPEDSKLS :*.*: * .* *. . ***:: .***:.*.:********.:* ENSP00000427567/1-1143 RAHSEGPESPKEEPKTPSVPSVPHELPRVPSFARNTVASSSRSMRTDLPPVAKAPGITRT ENSMUSP00000088525/1-1149 SPNSPDPESPKEEPKAPQATGVSRALPPIPSFARNTVASSSRSLRTDAPPAARTTGLTRT ENSRNOP00000060810/1-1148 SPNSRDPESPKEEPKAPQAPGASRALPPTPSFARNTVASSSRSMRADAPPAARATGITRT ENSCPOP00000018374/1-989 -------------------------------FARNTLASASRCVRPE--PAPRGPGLMRT XP_004869280.1/1-1066 F-------SPAQRPEEKPKTSPARGPPSTPGFARSTFASSSRCVRTDATPAARTPGLTRT ***.*.**:**.:*.: *..: .*: ** ENSP00000427567/1-1143 VSQRQLRVKGDPEDAAPKDSSTLRRASSARAPKKRPESAEGPSANTEAPLKARGAGERAS ENSMUSP00000088525/1-1149 VSQRQLRVKGGSEDSASKDIGTLKRASSARASKKCPESAGGSSANVETSLKGRGTTERSS ENSRNOP00000060810/1-1148 VSQRQLRVKSGSEDSASKDSGTLKRASSARASKKCPESAGGSSANVETPLKGRGTTERSS ENSCPOP00000018374/1-989 ASQRQLRAKGGPEDTDS----TLRRTSSARVPRRSSEAGEGPGAGAEAPSKSR-AGERGA XP_004869280.1/1-1066 VSQRQLGPKGGPEDAAPKDSGPLRRASSARVPKKGAESTEGPGA----------VSGRAA .***** *...**: . .*:*:****..:: .*: *..* . *.: ENSP00000427567/1-1143 LRRKDSSRTTLGRILNPLRK ENSMUSP00000088525/1-1149 LRLKDSGQATLGRILRPLQK ENSRNOP00000060810/1-1148 LRLKDSGQATLGRILRPLQK ENSCPOP00000018374/1-989 PRQQGPARTALGRILEPLWK XP_004869280.1/1-1066 PRRQSSGRTALGRILHPLGK * :...:::*****.** *