CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000125453/1-1334 MKVTVCFGRTRVVVPCGDGRMKVFSLIQQAVTRYRKAVAKDPNYWIQVHRLEHGDGGILD ENSRNOP00000048964/1-889 ------------------------------------------------------------ XP_004861924.1/1-1312 MKVTVCFGRTRVVVPCGDGHMKVCSLVQQAVTRYRKAIAKDPSYWIQVHRLEHGDGGILD ENSCPOP00000014151/1-1314 ----------------------------------------DPSYWIQVHRLEHGDGGILD ENSP00000363921/1-1356 MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD ENSMUSP00000125453/1-1334 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ ENSRNOP00000048964/1-889 ------------------------------------------------------------ XP_004861924.1/1-1312 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPETLGSELGAGTVSAFQPYR ENSCPOP00000014151/1-1314 LDDTLCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ ENSP00000363921/1-1356 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ ENSMUSP00000125453/1-1334 ATSEIEVTPSVLRANMPLHVRRSSDPALTGLSTSVSDNNFSSEEPSRKNPTRWSTTAGFL ENSRNOP00000048964/1-889 ---------------MPLHVRRSSDPALTGLSTSVSDNNFSSEEPSRKNPTRWSTTAGFL XP_004861924.1/1-1312 ATSEIEVTPSVLRANMPLHVRRSSDPALIGLPASVSDSDF-SEEPSRKNPTRWSTTAGFL ENSCPOP00000014151/1-1314 ATSEIEVTPSVLRANMPLHVRRSSDPALIGLPTSVSDNDF-SEEPSRKNPTRWSTTAGFL ENSP00000363921/1-1356 ATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFL ************* **.:****.:* ******************* ENSMUSP00000125453/1-1334 KQNTAGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDNARSSLSASHPMVDRWLEKQEQDE ENSRNOP00000048964/1-889 KQNTTGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDNARSSLSASHPMVDRWLEKQEQDE XP_004861924.1/1-1312 KQNAAGSPQSCERKKDENYRSLPRDTSNWSTQFQRDNARTSLSASHPMVDQWLEKQEQEE ENSCPOP00000014151/1-1314 KQNTAGSPQTSDRKKDENYRSLPRDTSNWSTQFQRDSARTSLSASHPMVDKWLEKQEQEE ENSP00000363921/1-1356 KQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASHPMVGKWLEKQEQDE ***::***::.:*************.*.**.*****.**:*********.:*******:* ENSMUSP00000125453/1-1334 EGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLG ENSRNOP00000048964/1-889 EGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLG XP_004861924.1/1-1312 DGT-EDSSRVEPVGHADTGLESVTNFSLDDMVKLVQVSNDGGPLGIHVVPFSARGGRTLG ENSCPOP00000014151/1-1314 DGLAEDSSRVEPVGHADTGLESVTSFSLDDLVKLVQVSNDGGPLGIHVVPFSARGGRTLG ENSP00000363921/1-1356 DGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLG :* **.************** :..*****:****:*.********************** ENSMUSP00000125453/1-1334 LLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRARVIWFHVVPA ENSRNOP00000048964/1-889 LLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRARVIWFHVVPA XP_004861924.1/1-1312 LLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA ENSCPOP00000014151/1-1314 LLVKRLEKGGKAEQENLFHENDCIIRINDKDLRHKRFEEAQCTFREAMCAPIIWFQVIPA ENSP00000363921/1-1356 LLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA *************:****:*****:**** ***::***:** **:** : :***:*:** ENSMUSP00000125453/1-1334 ANKEQYEQLSQREKNNYSPGRFSPDSHCVANRSVANNAPQALPRAPRLSQPPEQLDAHPR ENSRNOP00000048964/1-889 ANKEQYEQLSQREMNNYSPGRFSPDSHCVANRSVANNAPQALPRAPRLSQPPEQLDAHPR XP_004861924.1/1-1312 ANKEQYEQLSQSERSSYYSSRFSPDSQFLDSRASGSAGPHAPARVPRASLASEQTDAPLR ENSCPOP00000014151/1-1314 TNKEQYEQVSQSEKGSCYSSRFGPDSQYSDNRSVTSTGPHVLPRASRLNPPPEHADAPPR ENSP00000363921/1-1356 ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSR :*******:** * .. ..**.***: .*: . . :. *..* . ..*: *: * ENSMUSP00000125453/1-1334 LPHSAHASTKPPAAPALAPPSVLSTNVGSVYNTKKVGKRLNIQLKKGTEGLGFSITSRDV ENSRNOP00000048964/1-889 LPHSAHASTKPPTAPALAPPNVLSTSVGSVYNTKRVGKRLNIQLKKGTEGLGFSITSRDV XP_004861924.1/1-1312 LPHALHPSAKPPAAP--APHSVLGSSAGSGYNTKKVGKRLSIQLKKGTEGLGFSITSRDV ENSCPOP00000014151/1-1314 LPHGTHPSAKPPAAP--APHSVFSPSASSGYNTKKVGKKLNIQLKKGTEGLGFSITSRDV ENSP00000363921/1-1356 LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDV ***. *.* ***:** ** .*:.....* ****::**:*.******************* ENSMUSP00000125453/1-1334 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTV ENSRNOP00000048964/1-889 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTV XP_004861924.1/1-1312 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTV ENSCPOP00000014151/1-1314 TIGGSAPIFVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTRMEGTV ENSP00000363921/1-1356 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV ********:******************************.**************:***** ENSMUSP00000125453/1-1334 SLLVFRQEE-AFHPREMNAEPSQMQTPKETKAEDEDVVLTPDGTREFLTFEVPLNDSGSA ENSRNOP00000048964/1-889 SLLVFRQEE-AFHPREMNAEPSQMQSPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSA XP_004861924.1/1-1312 SLLVFRQED-AFHPRELNAEPSQMQIPKETKAEEDDVVLTPDGTREFLTFEVPLNDSGSA ENSCPOP00000014151/1-1314 SLLVFRQEDAAFHPRELNAEPSQMQIPKETKAEEEDIVLTPDGTREFLTFEVPLNDSGSA ENSP00000363921/1-1356 SLLVFRQED-AFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSA ********: ******:******** *******::*:*********************** ENSMUSP00000125453/1-1334 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKANQEAM ENSRNOP00000048964/1-889 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKANQEAM XP_004861924.1/1-1312 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM ENSCPOP00000014151/1-1314 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM ENSP00000363921/1-1356 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM ******************************************************:**:** ENSMUSP00000125453/1-1334 ETLRRSMSTEGNKRGMIQLIVARRISRCNELRSPGSPAAPELPIETELDDRERRISHSLY ENSRNOP00000048964/1-889 ETLRRSMSTEGNKRGMIQLIVARRISRCNELRSPGSPAAPELPIETELDDRERRISHSLY XP_004861924.1/1-1312 ETLRRSMSTEGNKRGMIQLIVARRISKCHELRSPGSPTGPELPIDTVLDDRERRISHSLY ENSCPOP00000014151/1-1314 ETLRRSMSTEGNKRGMIQLIVARRISKCQELRSPGSPPGPELPIETVLDDRERRISHSLY ENSP00000363921/1-1356 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLY **************************:*:**:*****..*****:* ************* ENSMUSP00000125453/1-1334 SGIEGLDESPTRNAALSRIM---GKCQLSPTVNMPHDDTVMIEDDRLPVLPPHLSDQSSS ENSRNOP00000048964/1-889 SGIEGLDESPTRNAALSRIMGESGKCQLSPTVNMPHDDTVMIEDDRLPVLPPHLSDQSSS XP_004861924.1/1-1312 SGLEGLDESPSRNVALSRIM---GKYQLSPTVNMPQDDTVIIEDDQLPVLPPHLSDQSSS ENSCPOP00000014151/1-1314 SGLEGLDESPTRNAALSRIMGESGKYQLSPTVNMPHDDTVIIEDDRLPVLPPHLSDQSSS ENSP00000363921/1-1356 SGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSS **:*******:**.****** ** *********:****:****:************** ENSMUSP00000125453/1-1334 SSHDDVGFIMTEAGTWAKATISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDA ENSRNOP00000048964/1-889 SSHDDVGFIMTEAGTWAKATISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSNA XP_004861924.1/1-1312 SSHDDVGFVPSDAAVWAKTAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDA ENSCPOP00000014151/1-1314 SSHDDVGFVTTDAAAWAKVAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDA ENSP00000363921/1-1356 SSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDA ********: ::*..***.:**************************************:* ENSMUSP00000125453/1-1334 SQLDFVKTRKSKSMDLGIADETKLNTVDDQRAGSPSRDVGPSLGLKKSSSLESLQTAVAE ENSRNOP00000048964/1-889 SQLDFVKTRKSKSMDLGIADETKLNTVDDQRAGSPNRDVGPSLGLKKSSSLESLQTAVAE XP_004861924.1/1-1312 SQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAE ENSCPOP00000014151/1-1314 SQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAE ENSP00000363921/1-1356 SQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAE ******************************:****.************************ ENSMUSP00000125453/1-1334 VTLNGNIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPMVDDDDEGMETLEEDTEESSRSG ENSRNOP00000048964/1-889 VTLNGNIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPMVDDDDEGMETLEEDTEESSRSG XP_004861924.1/1-1312 VTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSG ENSCPOP00000014151/1-1314 VTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPVMDDDDEGMETLEEDTEESSRSG ENSP00000363921/1-1356 VTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSG *****:******************************* :********************* ENSMUSP00000125453/1-1334 RESVSTSSDQPSYSLERQMNGDPEKRDKTERKKDKAGKDKKKDREKEKDKLKAKKGMLKG ENSRNOP00000048964/1-889 RESVSTSSDQPSYSLERQMNGDPEKRDKAEKKKDKAGKDKKKDREKEKDKLKAKKGMLKG XP_004861924.1/1-1312 RESVSTASDQPSRSLERHMNGSQEKGDKADRRKDKAGKEKRKDGEKDKDKRKAKKGMLKG ENSCPOP00000014151/1-1314 RESVSTASDQPSHSLERHVNGNQEKGDKADRRKDKTGKEKKKDREKDKDKMKAKKGMLKG ENSP00000363921/1-1356 RESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKG ******:***** ****::**. ** **::::***:**:*:** :*:*** ********* ENSMUSP00000125453/1-1334 LGDMFRFGKHRKDDKMEKMGRIKIQDSFTSEEDRVRMKEEQERIQAKTREFRERQARERD ENSRNOP00000048964/1-889 LGDMF------------------------------------------------------- XP_004861924.1/1-1312 LGDMF-------------------------------------RIQAKTREFRERQARERD ENSCPOP00000014151/1-1314 LGDMFRFGKHRKDDKIEKTGKIKMQESFTSEEERIRMKQEQERIQAKTREFRERQARERD ENSP00000363921/1-1356 LGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQARERD ***** ENSMUSP00000125453/1-1334 YAEIQDFHRTFGCDDELLYGGMSSYEGCLALNARPQSPREGHLMDTLYAQVKKPRSSKPG ENSRNOP00000048964/1-889 ------------------------------------------------------------ XP_004861924.1/1-1312 YAEIQDFHRTFGCEDELMYGGMASYEGSLALSARPQSPREGHMMDALYAQVKKPRNSKAS ENSCPOP00000014151/1-1314 YAEIQDLHRTFGCEDELMYGGLSSYEGSVALNAGPQSPREGHMMDALYAQVKKPRNSKAS ENSP00000363921/1-1356 YAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPS ENSMUSP00000125453/1-1334 --DSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSSSRPASQSGRHSVSV ENSRNOP00000048964/1-889 ------------------------------------------------------------ XP_004861924.1/1-1312 TVDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPGSRPAAQSGRHSVSV ENSCPOP00000014151/1-1314 PVDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPGSRPAVQSGRHSVSV ENSP00000363921/1-1356 PVDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPNARPATQSGRHSVSV ENSMUSP00000125453/1-1334 EVQVQRQRQEERESFQQAQRQYSSLPRQSRKNASSISQDSWEQNYAPGEGFQSAKENPRY ENSRNOP00000048964/1-889 ------------------------------------------------------------ XP_004861924.1/1-1312 EVQVQRQRQEERESFQQAQRQYSSLPRQSRKNSSSASQDSWEQNYAPGEGFQSAKENPRY ENSCPOP00000014151/1-1314 EVQVQRQRQEERESFQQAQRQYSSLPRQSRKNASSVSQDSWEQNYPPGEGFQSAKENPRY ENSP00000363921/1-1356 EVQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRY ENSMUSP00000125453/1-1334 SSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQLKKQPPADGV------------ ENSRNOP00000048964/1-889 ------------------------------------------------------------ XP_004861924.1/1-1312 SSYQGSRNGCMGGHGFNARVMLETQELLRQEQRRKEQQMKRQPPAEGSSSYDSYKKAQDP ENSCPOP00000014151/1-1314 SSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQSPPEGPSTYDSYKKVQDP ENSP00000363921/1-1356 SSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDP ENSMUSP00000125453/1-1334 -----RGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS ENSRNOP00000048964/1-889 ------------------------------------- XP_004861924.1/1-1312 GCPPPKGPFRQDVPPSPSQVARLNRLQAPEKGRPFYS ENSCPOP00000014151/1-1314 NCPPPKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS ENSP00000363921/1-1356 SYAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS