CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000108050/1-1241 -----------------------------------------MDRSVPDPLPRSAPRTPAM ENSRNOP00000059197/1-1213 ------------------------------------------------------------ ENSP00000194871/1-1233 MPPSWSPLMCGRAAEAAASSRTPGREMGQAVTRRLGAGARAAPRRAMDGRTPRPQDAPAR ENSCPOP00000010623/1-1151 ------------------------------------------------------------ XP_004836201.1/1-1208 -----------MAAHPHGETTAGGSLMVNELEPYINVRGEGGVQKDALQRQQEDEQTPFE ENSMUSP00000108050/1-1241 QPAGSAGRKTKGKAPLPPAETKGTDVSSAEDPVESTAVVTEQQDNMIDKDIELSVVLPGD ENSRNOP00000059197/1-1213 -------RKTKAKAPLPPAEMKGMDVSSAEDPVESIPVSTEQHDNMIDKDIELSVVLPGD ENSP00000194871/1-1233 REIAGSWRKPKAKAPLPPAETKYTDVSSAADSVESTAFIMEQKENMIDKDVELSVVLPGD ENSCPOP00000010623/1-1151 R------RKTKAKAPLPPAETKYVDASSFDDSVESAAFIMEQKENIIDKDIDLTVVLPGD XP_004836201.1/1-1208 K------RKTKAKAPLPPSETKYVDVSSIDDSVESAAFIMEQKENIIDKDIDLTVVLPGN **.*.******:* * *.** *.*** .. **::*:****::*:*****: ENSMUSP00000108050/1-1241 ILKSTTVHGSKPMMDLLVFLCAQYHLNPSSHTIDLLSAEENLIKFKPNTPIGMLDVEKVI ENSRNOP00000059197/1-1213 VLKSTTVHGSKPMMDLLVFLCAQYHLNPSSHTINLLSAEENLIKFKPNTPIGMLEVEKVI ENSP00000194871/1-1233 IIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAEQNHIKFKPNTPIGMLEVEKVI ENSCPOP00000010623/1-1151 IIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAEKNNIKFKPNTPIGMLDVEKVI XP_004836201.1/1-1208 IITSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAEKNNIKFKPNTPIGILDIEKVI ::.**************:************:**:*****:* **********:*::**** ENSMUSP00000108050/1-1241 LKPKSLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPHAPLQDLAPIICSKCEFDPLHT ENSRNOP00000059197/1-1213 LKPKSLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPHSPLQDLAPIICSKCEFDPLHT ENSP00000194871/1-1233 LKPKMLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPHASLQELAPIICSKCEFDPLHT ENSCPOP00000010623/1-1151 LKPKNLDKKKPTPIIPEKTVRVVINFKKTQKAIVRVSPHASLQELVPTICSKCEFDPSHT XP_004836201.1/1-1208 LKPKNLDKKKPTPIIPEKTVRVVINFKKTQKAIVRVSPHAFLQELVPTICSKCEFDPLHT **** **************************:*******: **:*.* ********* ** ENSMUSP00000108050/1-1241 VLLKDYQAQEPLDLTKSLNDLGLRELYAMDISR-------------ESCQISHNPDIVKE ENSRNOP00000059197/1-1213 VLLKDYQAQEPLDLTKSLNDLGLRELYAMDISR-------------ESCQISHNPDIVKE ENSP00000194871/1-1233 LLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRATSVTVFSKSSLQESCQISQNLDIMKE ENSCPOP00000010623/1-1151 LLLKDYQSQEPLDLTKSLNDLGLRELYAMDVSG-------------ESSQVSPNLDIMKE XP_004836201.1/1-1208 LLLKDYQSQEPLDLTKSLNDLGLRELYAMDVSG-------------ESSQISPNLDIMKE :******:**********************:. **.*:* * **:** ENSMUSP00000108050/1-1241 KENKGIFSFFQRSKKKREQTASAPATPLVSKHRPSFTRSNTISKPYISNTLPSDAPKKRR ENSRNOP00000059197/1-1213 KENKGIFSFFQRSKKKREQTASAPATPLVSKHRPSFTRSNTISKPYISNTLPSDAPKKRR ENSP00000194871/1-1233 KENKGFFSFFQRSKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRR ENSCPOP00000010623/1-1151 KESKGFFSFFQRSKKKREQTASAPATPLINKHRPTFVRSNTLSRPYVSNTLPSDAPKKRR XP_004836201.1/1-1208 KENKGFFSFFQRSKKKREQTASAPATPLINKHRPTFVRSNTLSRQYVSNTLPSDAPKKRR **.**:***********:**********:.****:*.****:*: *:************* ENSMUSP00000108050/1-1241 APLPPMPTSQGAAQG----QERRASCVERSTSVDDTDKSSSEAIMVRTGSLQLS-STSIG ENSRNOP00000059197/1-1213 APLPPMPTSQGAAQG----QERRASCVERSTSVDDTDKSSSEGFMVRTGSLQLSGSTSVG ENSP00000194871/1-1233 APLPPMPASQSVPQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLS-SMSAG ENSCPOP00000010623/1-1151 APLPPMLASQIAPQDLEQPQERAGSSVVKSTGVEEADESPREAGRARTGSLPLS-STSEG XP_004836201.1/1-1208 APLPPMLSSQSTPQDLEKAQERPGSSVSKSTGVEEAEKSPREVVRTRTGSLPLT-STSEG ****** :** ..*. *** .*.: :* .*:::::*. * .*:*** *: * * * ENSMUSP00000108050/1-1241 TSSLKRTKRKAPAPPSKTPLAQTDERNSAMAHGLPLEDGIAPDSMLELSSPEGMSTP--- ENSRNOP00000059197/1-1213 TSSLKRTKRKAPAPPSKPSLTETDEGSSAAAHGLPLEDGIVPDSISEVSSPEGMSSP--- ENSP00000194871/1-1233 NSSLRRTKRKAPSPPSKIPPHQSDENSRVTA--LQPVDGVPPDSASEANSPEELSSP--- ENSCPOP00000010623/1-1151 NLSLKRTKRKAPSPPTKIPLRQSTENGHPTV--LQAVDGVSPDSISEATSPEGLPSP--- XP_004836201.1/1-1208 NSSLKRTKRKAPSPPSKIPLHQSDENGHVTA--LQAGDSVSPDSASEATSPEGLPSPDST . **:*******:**:* . :: * . . * *.: *** * .*** :.:* ENSMUSP00000108050/1-1241 ---EGSLGPGFLSQEQCAVPKPPDE--ISEGPGTPEAAVASLTSGVSSDYSLEEIDEKEE ENSRNOP00000059197/1-1213 ---GNEEGPGFLSQEECSVPKPMDE--ISEGPGTPEAAVASMTSGVSSDYSLEEIDEKEE ENSP00000194871/1-1233 ----ETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEE ENSCPOP00000010623/1-1151 ---EGCLGPGLFHQERCTTPKLPDESSLSEGPGTPEAAVASLTSGISSDYSLEEIDEKEE XP_004836201.1/1-1208 SLAEGSLGPGLFYQEQRASPKLPDETSLSEGPGTPEAAVASWTSGVSSDYSLEEIEEKEE **: **. : ** :* : * *******::* ***:*********:**** ENSMUSP00000108050/1-1241 LSEASKDPAGSISVKSPDIASASTDMRITVEKDPDSALGISDGETSPSSKGKTQEGRSTE ENSRNOP00000059197/1-1213 LMEASKDQAGSV--KSPTIASASTDMIITAENDPDSALSISDGETSPGSKGNTPEGRNPE ENSP00000194871/1-1233 LSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTD ENSCPOP00000010623/1-1151 LSEMPKHEAENISLKSPDIAFVSTDIISTLKKDPDSVLGTDSGEASQNSKEENQEAGNTD XP_004836201.1/1-1208 LSEVPKDEAEDISLKSPDIPFVSTD-INTLKKDLDSVFGTDGGEASQNSKEKKQ-ATNTD * * .* * .: ** *. .*** * ::* **.:. ..** * .* :. ..: ENSMUSP00000108050/1-1241 G---------QGPYHPVVGHIGNEDRVSDSIKDMKTLGPNQESVVQNEIMVCATST-DYV ENSRNOP00000059197/1-1213 G---------QGPHHPVECLIGNENNVSDSIKDLKTLSPNQESVIQNEVVVCATST-DYV ENSP00000194871/1-1233 G---------QEP-HSVVYDTSNGKKVVDSIRNLKSLGPNQENVVQNEIIVYPENTEDNM ENSCPOP00000010623/1-1151 G---------QGS-HSVVYDSSNENMLPDGVRNLQSLSPNEKNV-QNETNILATKTEDKM XP_004836201.1/1-1208 GHITYTITSSRGA-HGVVYGTSNEDMVADHVGNLQSLGPNQKNV-QNETIVLATKTEDKM * : . * * .* . : * : ::::*.**::.* *** : . .* * : ENSMUSP00000108050/1-1241 KNRPGKMETTIEGEGEALKKASDMETDRLSGSPACRMDNVKSSRENHLTASPGPDQKLNQ ENSRNOP00000059197/1-1213 KNRPREME--ATIEGEAQKKVGDVEAERLSGSPAGRMDDVQSSRENHLTASPGPDQKSNQ ENSP00000194871/1-1233 KNGVKKTE--INVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQ ENSCPOP00000010623/1-1151 KNSVRKTE--ICVD-EAKNKDINMRVDKLPQCRACETDSFISSKENHGVVASLPDQKLNQ XP_004836201.1/1-1208 KSSVRRTE--ICGEDEAKRKDMNMGADKLSKCQACEPDS-LSSKEGLQAVISVPDQKLNQ *. . * : * .: :: .:: . . * . * * :*. .. . **** ** ENSMUSP00000108050/1-1241 PGVEKTKMQDAAIQATPARGTFDGNHEVSNSSDPRADETVQTSDGSISAQHSSASLQDSV ENSRNOP00000059197/1-1213 PRVEKTKMQDAAIQATPACSTFDGNHEAHNSPDLRVDETAQTLGSSTSTQHSSASFQDSV ENSP00000194871/1-1233 PSAEKTK--DAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSV ENSCPOP00000010623/1-1151 HRTEKTKMQDAAIQTTPSCNSLNGNHQDRNLSDFKVDESVQTSNNK-STQHSSLILQDSA XP_004836201.1/1-1208 PRGEKTKMQDAAIQTTPSCNSFDGNHQHHHLP----DESVQTSNNR-LTQHSALSLQDAV **** *****:**: .:::*:*: : . :* .** .. :***. **:. ENSMUSP00000108050/1-1241 NASREFRSQGT-STYVQDRLPEKEPACTYGNNVPLSPVDGSNKNPAASYLKNFPLYRQDS ENSRNOP00000059197/1-1213 NASREVRSQGT-STYVQDRLPVKEAACTYGNNDALSPIDGSGKNPAASSLKNFPLYRQDN ENSP00000194871/1-1233 NTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDY ENSCPOP00000010623/1-1151 NTTSKLRSQGTLTVYTEDRLARKDPVYAYGSDDLSSPIDGIDKNSTVSYLQNSPLYRQDY XP_004836201.1/1-1208 DASSRLRSQGSLPVHPEDRPTRKDPVYAYGNDELSSPVDKIDKNSTISYLKNSPLYRQDY ::: ..****: : :* . *:. ::*.: .*:* .**.: * *:* ****** ENSMUSP00000108050/1-1241 NPKPKPSNEITREYIPKIGMTTYKIVPPKSLEMAKDWESEAMGRKDDQKMLPVGQRHTIE ENSRNOP00000059197/1-1213 HPKPKPSNEITREYIPKIGMTTYKIVPPKSLEVVKDWDSEAAGKKDNQKTLAVAQKHAIE ENSP00000194871/1-1233 NPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKKHTHE ENSCPOP00000010623/1-1151 SAKPKPSNEITRDYIPKVGMTTYKIVPLKSLEILKDGESESVVFKDDQKLHTLGKKHAYE XP_004836201.1/1-1208 NPKPKPSNEITREYIPKIGMTTYKIVPPKSLEIQKDWESETMVFKDNQKINTLGKKHVSE .**********:****:********* ****: ** :**: **:*. .:.::*. * ENSMUSP00000108050/1-1241 NMTETSMQTEVPATSKSS-QQPQPDLKPKPSSGTERHLHRTLSSPTGTETNPPKA-PRVT ENSRNOP00000059197/1-1213 TMTETAVQAEALVTSKNS-QQPQPDRTPKPSSGTEHPLHRTVSSPVGTEMNPPKP-PRMT ENSP00000194871/1-1233 NVKETAIQTEDSAISESP-EEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMT ENSCPOP00000010623/1-1151 NVKETSIQTENTAASDGPVEEHKQGLTPKPSLRAAQQLHRAMSFTDEVVTKPPKP-PRMT XP_004836201.1/1-1208 NVKETSMQTENTATSEGP-MKPEQDLKPKPSLRTEHQLHRAMSFPDGAVTNPLKP-PRMT .:.**::*:* . *... : . .***. : : : ::* . . .* *. *::* ENSMUSP00000108050/1-1241 TDTGTIPFAPNLEDINNILESKFRSRASNPQAKPSSFFLQMQKRASGHYVTSAAAKSVHT ENSRNOP00000059197/1-1213 TDTGTIPFAPNLEDINNILESKFRSRASNPQAKPSSFFLQMQKRASGHYVTSAAAKSVHT ENSP00000194871/1-1233 RDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHA ENSCPOP00000010623/1-1151 GDTGTAPFAPTLEDINNILESKIKPQISNPQAKPNSFFLQMQKRASGHYVTSAAAKSTHT XP_004836201.1/1-1208 GDTGMPPFTPTLEDINNILESKIKSRASNPQAKPNSFFLQMQKRASGQYVTSAAAKNTHT *** **:*.**:********::.: **.****.*********.**:********..*: ENSMUSP00000108050/1-1241 APGPAPKEPTIKEVQRDPQLSPEQHPSSLSERTHSAPLPNISKADDDII-QKPAETSPPP ENSRNOP00000059197/1-1213 APGPTPKEPTIKEVQRDPQLPPEQCLSPLSERTHSAPLPNISKADDNRI-QKPAETSPPP ENSP00000194871/1-1233 APNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASP-- ENSCPOP00000010623/1-1151 APNVTPKELPNRDSGKDTLPSPEQTLSPLSKTTHCTPLPHVRHTGEAVLTQKPA---P-- XP_004836201.1/1-1208 APNPTPKELSNKDVERDTLPSPEQPLSPLSKTTLCTPQPHIKNTDDAVFTQKPA---P-- **. :*** . :: :* .*** *.**: . ..* * : ::.: : * ** * ENSMUSP00000108050/1-1241 VAPKPMTLRAETSPPPVFPKPMTLPAETSPPPVFPKPMTLPAETSLPLVFPKPMTLRAET ENSRNOP00000059197/1-1213 VAPKPMALPAETSPPAVAPKPMAFPAETSLPPVSPKPMAFPAETSLPPVAPKPMALPTEA ENSP00000194871/1-1233 ------------------------------------------------------------ ENSCPOP00000010623/1-1151 ------------------------------------------------------------ XP_004836201.1/1-1208 ------------------------------------------------------------ ENSMUSP00000108050/1-1241 SPPPVAAKPVALPGSQGTSLNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKACPES ENSRNOP00000059197/1-1213 SPPPVAPKPLALPGSQGASLNLKTLKTFGAPRPYNSSAPSPFALAVVKRSQSFSKASPES ENSP00000194871/1-1233 --PPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTES ENSCPOP00000010623/1-1151 --PPIAPKPVPLPTPQPAAVNLKTLKTFGAPRPFSSSTSSPFALAVVKRSQSFSKVHTEP XP_004836201.1/1-1208 --PPIAPKPVPLPTTQPAAVNLKTLKAFGAPRPFSSSTPSPFALAVVKRSQSFSRVRTES **:*.**:.:* .* :: ******:******:.** .***************: .*. ENSMUSP00000108050/1-1241 ASEGSSALPPAATQDEKTHTVNKPTVGSQHGDGDKQNNPVQNEHSSQVLTPADGP-SFTL ENSRNOP00000059197/1-1213 PSEDSSAQPPAAIQDGKTQTVNQPTVGSQHDGVDKQNKPVQNEHSSQRLTPADGPSSFTL ENSP00000194871/1-1233 PSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGP-SFTV ENSCPOP00000010623/1-1151 SSEEEAAQPPASADDRKTGSVNKFPDVPRLDATENQNNSAHNEQNSKMPTPTDCP-SFTL XP_004836201.1/1-1208 SSEADVVQPPANTEDEKTCFVNKFSDVPRLDVTEKQNNSAHNEQNSQMPTPTDCP-SFTL .* . *** :: ** **: .: . :::*:..:**:.*: **:* * ***: ENSMUSP00000108050/1-1241 KRQSSLTFQSSDPEHVRQSLLTAIRSGEAAAKLKRVTVPSNTISVNGKSGLSQSMSIDAQ ENSRNOP00000059197/1-1213 QRQSSLNFQSSDPEHIRQSLLTAIRSGEAAAKLKRVTVPSNRISVNGKSGLSQPMSIDAQ ENSP00000194871/1-1233 MRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKRVTIPSNTISVNGRSRLSHSMSPDAQ ENSCPOP00000010623/1-1151 KRQSSLTFQSSDPEQIRQSLLTAIRSGEAAAKLKRVTVPSNTISVNGRSRLSQSLSSDAQ XP_004836201.1/1-1208 KRHSSLTFQSSDPEQIRQSLLTAIRSGEAAAKLKRVTVPSNTISVNGRSRLSHSLSSDAQ *:***.*******::*********************:*** *****:* **:.:* *** ENSMUSP00000108050/1-1241 DSR ENSRNOP00000059197/1-1213 DSC ENSP00000194871/1-1233 DGH ENSCPOP00000010623/1-1151 EGC XP_004836201.1/1-1208 EGC :.