CLUSTAL W(1.81) multiple sequence alignment ENSP00000370299/1-1616 MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGS ENSMUSP00000098701/1-1487 MEGAEPRARPERLAEAEAPATDGVRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGS ENSRNOP00000056187/1-1491 MEGAEPRARPERLAEAEARATDGVRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGS ENSCPOP00000009258/1-1385 ----------------------------------------------------VLQIEEGS XP_004867441.1/1-1578 ---------MEGLAEVEARASDRGRLVEVRLSGGAPWGFTLKGGREHGEPLVITKIEEGS : :***** ENSP00000370299/1-1616 KAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHAT ENSMUSP00000098701/1-1487 KAAAVDKLLAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHAT ENSRNOP00000056187/1-1491 KAASVDKLLAGDEIVAINDVTLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHAT ENSCPOP00000009258/1-1385 KAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRNDVSWRPHSWHAT XP_004867441.1/1-1578 KAAAVDKLLAGDEIVGINDVGLSGFRQEAICLVKGSHKTLKLVVRRRSDVSWRPHSWHAT ***:***********.***: ***********************:*:.: .********* ENSP00000370299/1-1616 KFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDS ENSMUSP00000098701/1-1487 KYFDVHPEPAASLFLNTSGSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDS ENSRNOP00000056187/1-1491 KYFDVHPEPPVSLFLNSSSSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDS ENSCPOP00000009258/1-1385 KFSDDHPEPAASQFPSTSGCSSWHGCHHTTSSSQDLSSSWEQRNLQRTSDHFSSLGSVDS XP_004867441.1/1-1578 KLSDGHAEPAASLLPASSGCSSWHGRHHASSSSQDLSGSWEPTNLQRTSDHFSSLGSVDS * * *.* ..* : :*...** . *:::***:***.*** .**** *****:**:** ENSP00000370299/1-1616 LDH-----PSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHT-LSKADTSSAEN ENSMUSP00000098701/1-1487 LDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHT-LPKADASSTEN ENSRNOP00000056187/1-1491 LDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHT-LPKADASSTEN ENSCPOP00000009258/1-1385 LDHPSQPSPSGHLLAAKSNSSINHLGGPNQRDSAYGSFSTSSGTPDHT-LPKAEASSVEN XP_004867441.1/1-1578 LDHPSQPYPSGHLSAAKSSSSIDHLGGPNQRDSAYGSFSTSSSTPDHTLLPKAEASSAEN *** **.:* ***.***:***. .:**********.*.***** *.**::**.** ENSP00000370299/1-1616 ILYTVGLWEAPRQG-GRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAP ENSMUSP00000098701/1-1487 ILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATH ENSRNOP00000056187/1-1491 ILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSSFLPRVPGNSSKSPRPEDNIEPKIATS ENSCPOP00000009258/1-1385 ILHKVGLWEAA-------------PQALEERPSTFLSRAPGDSSKSPRPEDTVEPKLTAS XP_004867441.1/1-1578 ILYKVGLWAAS-------------PQSLEERPSAFPPRAPGDNRKSPRPEDGTEPKPATS **:.**** *. **. ::: * * .*.**:. *.**** *** :: ENSP00000370299/1-1616 GRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFA-ATKSHEKAQGPVFSEAAAAQHFTAL ENSMUSP00000098701/1-1487 GRSNFGPVWYVPDKKKA-PSPPPLGLPLRSDSFSVAARGHEKARGPPFSDLASMQHFITL ENSRNOP00000056187/1-1491 GRSNFGPVWYVPDKKKA-PSPPPLGLPLRSDSFAVAARGHEKARGPPFSDLASMQHFTTL ENSCPOP00000009258/1-1385 SRSSFGPIWHVPDKKKAPPSPPPPAPPLRSDSFA-ATKNHEKPLGPPFSEVAATKLSAAP XP_004867441.1/1-1578 GRSSFGPVWHIPDKKKAPPSPPPPAPPLRSDSFA-ATQSHEKTQGPPFLEAATTQHLPAP .**.***:*::****** .**** *******: *::.***. ** * : *: : : ENSP00000370299/1-1616 AQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKD------GASS ENSMUSP00000098701/1-1487 PHVQPRGDHRMETTDRQWKLTHL-SSGKEIGNVGYQSEGHLDCRWLCSDDRAGRPSGPPG ENSRNOP00000056187/1-1491 PHVQPRGDRRMETTDRQWKLAHP-SSGKEIGNVGYQPEGHLDCRWLCSDDRAGRPSGAPG ENSCPOP00000009258/1-1385 IQLQPRGDWRSDLADRQRRPRCL-SIGKESG-------GHHECSQP------G---GPLG XP_004867441.1/1-1578 VRVQPRGEWRPDLASWQWRPGGP-SSGKEAG-------GHPDCGWPGGDERAG---GPLG : ****: * : :. : * ** * .* : *. . ENSP00000370299/1-1616 RLQASLSSSDVRFPQSPHSGRHPPLYSDHS-PLCADSLG-----------QEPGAASFQN ENSMUSP00000098701/1-1487 RLQFS----DVHFLKSYHGSQHQQQCSDES-PRAPSSPRELLHITPGGGLQEPPEPS-QD ENSRNOP00000056187/1-1491 RHQFSLSSTDVHFLKSYHGSQHPQPCSDES-PRFPSSPRELLRITPSGCLQEPPELS-QD ENSCPOP00000009258/1-1385 RVQASLSSADAPQTQPPHRGQHLCQCSDEGVTGKPMSLREWHRVAPSGGWQDLPVPQCQD XP_004867441.1/1-1578 RPQASLPSTDVRLARPPHGAQHPCQGSDEG-PRKPVPLRERPHVAPSAEWQELPVPRCQD * * * *. :. * .:* **.. . . . *: *: ENSP00000370299/1-1616 DSPPQVRGLSSCDQKLGSGWQGPRPCV------QGDLQAAQLWAGCWPSDTALGALESLP ENSMUSP00000098701/1-1487 DNPTQVRWPGSAHQKLDDRGRSHYFPGSLRQPVQGSAQVVIPRGDYWHSDTTPVDLEYPL ENSRNOP00000056187/1-1491 DNPAQVRWPGSVNQKLDDRGRSHYFSVPHRQPVHGSAHVLIPRSDYWHSDTTPVDLECPL ENSCPOP00000009258/1-1385 IGPPQVRWPKAADQ--------SYSCVAARQP--------PFPGECWHWNVAPGTSEYLS XP_004867441.1/1-1578 GGPPQARWPKAASQ-------GYYSCVATRQP--------PFLGECWHWGAVPRAFDCPP .*.*.* : * . * ... : ENSP00000370299/1-1616 -PPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGC-SAGAQEPPRASRAEKASQR-L ENSMUSP00000098701/1-1487 LRPV---GQRTYLQQHEETPASHEKEGYHQLNAGIEGC-CSGIQEPPRASRTVRTGLQCP ENSRNOP00000056187/1-1491 LRP----DQRGYPQQYEETPASHERGGYQQLNAGIEGC-CSGIHEPPRASHTVRAGLQCP ENSCPOP00000009258/1-1385 LHPVMNPNPRC--------PLARQEEPGPLPDTVTGGG-ALGFHKLSRTSHAEQGP---L XP_004867441.1/1-1578 SHQAVGPSLRC--------PLARHEEPGPLPNAAAEGGFSSGFHELRRASHVEQGTQGTL . * * ::. : * . * :: *:*:. : ENSP00000370299/1-1616 AASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDR ENSMUSP00000098701/1-1487 SNDFKLVDGESGRISRQRTPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRRSDR ENSRNOP00000056187/1-1491 GNDFKLVDAESGRISRQRTPMLHSLTQDGAWRPGNSKDCGNEKPPLLDAQVGKPTRRSDR ENSCPOP00000009258/1-1385 AGGFRVADGEGSRISRQRTPMLHSLSQEGQL-------GAMEKLPPFDAQVGRPARRSDR XP_004867441.1/1-1578 AGGCRWTDAEGGRISRQRTPMLHSLTQEGQV-------GGVEKLPPFDAQVGRPARRSDR . . .*.*..**. *.**:****:*:* . : * :**:**:*:***** ENSP00000370299/1-1616 FATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKDHLK ENSMUSP00000098701/1-1487 FATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRADV-GAVPEGSFPSTYKEHLK ENSRNOP00000056187/1-1491 FATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRVDV-GAVPEGSFPSTYKEHLK ENSCPOP00000009258/1-1385 FATTLRNEIQLRRAKLQKSKSTATLAEGSGANAKAGSWQAQP-GVPSEGAFSSTYKDHLK XP_004867441.1/1-1578 FATTLRNEIQIRRAKLQKSKSTVTLATASEGEGEASSWRPQA-GAASEGSFSSTYKVHLK **********::*******:**.:*: . .: :. *: * **.:..*** *** ENSP00000370299/1-1616 EAQARVLRATSFKRRDLDPNPGDLYPESLEHR-------------MGDPDTVPHFWEAGL ENSMUSP00000098701/1-1487 EAQTRVLKATSFQRRDLDPTPADQYSGPSEHRTFDHSASSSLSSFPGEPDSAPRFCETGL ENSRNOP00000056187/1-1491 EAQTRVLKATSFQRRDLDPTPADQYPGPPEHRTCDHSASSSLSSFPGEPDSAPRLCEAGL ENSCPOP00000009258/1-1385 EAQARVLRATSFKRRDLDPSPADQYPGPPEHRAREHGATLSC---PVEPDCAPHFWEAGL XP_004867441.1/1-1578 EAQGRVLRATSFKRRDLDPTPADQYPGPPEHRSGEHSTASSG---PGEPDSVPRFWEAGP *** ***:****:******.*.* *. . *** :** .*:: *:* ENSP00000370299/1-1616 AQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVG ENSMUSP00000098701/1-1487 AKAPSSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRPHPTVRTPEDTVG ENSRNOP00000056187/1-1491 AKPPSSAGGVPHILRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHSPHPTIRTSEDSVG ENSCPOP00000009258/1-1385 TKPASPGGGPPQVSRVGGRKRFTAEQKLKSYSEPEKMNQVGLLGDCSSHQHPGTPEDCMG XP_004867441.1/1-1578 AQPASSGGGPPQVPRVGGRKRFTAEQKLKSYSEPEKMNEVGLSGDCGPHQHPRGPEDTMG ::..*. * *: *:***:****************:*:*** . .* .** :* ENSP00000370299/1-1616 TFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTC---EGTEPW----SRT ENSMUSP00000098701/1-1487 TFADRWKFFEETSKSLLQKAGHRQVHCGLPREKAERPQTGHHEC---ESTEPWFQKRSLA ENSRNOP00000056187/1-1491 TFADRWKFFEETSKSLLQKPGHRQAFCGIPREKAERPQTQGHEC---ESTEPWFQKRSRA ENSCPOP00000009258/1-1385 TFADRWKFFEETSKPVLQRPGHRQAACGLPREKAERPRTAGMAGPGGENTEPRLQKRSRA XP_004867441.1/1-1578 TFADRWKFFEETSKPALQRLGQRQAVCGPLREKSEWPRTAGHAC---EGTESCFQKRTRA **************. *: .::*. * *:*.* *:* *.**. : : ENSP00000370299/1-1616 TSLGDSLNAHSAAEKAG-TSDLPRRLGTFAEYQASWKEQRKPLE-ARSSGRCHSADDILD ENSMUSP00000098701/1-1487 TSCGEILS-DRKVEKASEKLNPPRRLGTFAEYQASWKEQKKPLE-ARSSGRYHSADDILD ENSRNOP00000056187/1-1491 TSCGEILSEDRKVEKASEKLNPPRRLGTFAEYQASWKEQKKSLE-ARSSGRYHSADDILD ENSCPOP00000009258/1-1385 PSFGEILNGYRKVENPG-KLDPPQRLGTFAEYQASWKEQKKPLE-AISAGRCHSADDILD XP_004867441.1/1-1578 TSFGEILTGYRKAENPG-KLDPPQRLGTFAEYQASWKEQRKPLEKARSSGRCRSADDILD .* *: *. .*:.. . : *:***************:*.** * *:** :******* ENSP00000370299/1-1616 VSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTP ENSMUSP00000098701/1-1487 AGLDQQQRPQYIHERSRSSPSTDHYSQEVPVEPNRQAEDSGDHKEAILCTLQAEEGCSAP ENSRNOP00000056187/1-1491 AGLDQQQRPQYIHERSRSSPSTDHYSQEVPVEPNRQAEDSGGQKEALLCTLQAEEGCSAP ENSCPOP00000009258/1-1385 AALDQHQRPQYVHERSRSSPSTDHYVQEASVEPLRQPGNSGGHRETPASTVCVREAHCTP XP_004867441.1/1-1578 AGLDQHQRPRCVHERSRSSPSREHYTQETSVEPQRQAGDPGGDREAPLSAARVQEACSTP ..** ::**: :* ******* :** **..** **. :.* :* .: ..*. .:* ENSP00000370299/1-1616 RQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSE ENSMUSP00000098701/1-1487 SS---------------------------------------------------------- ENSRNOP00000056187/1-1491 SS---------------------------------------------------------- ENSCPOP00000009258/1-1385 SQ---------------------------------------------------------- XP_004867441.1/1-1578 RQADAQCPEASPAAWQDPAQQSARPPSSVSGSAPTREAPE-----------LPRDNRHSE . ENSP00000370299/1-1616 ESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPA ENSMUSP00000098701/1-1487 ------------------------------------------------------------ ENSRNOP00000056187/1-1491 ------------------------------------------------------------ ENSCPOP00000009258/1-1385 ------------------------------------------------------------ XP_004867441.1/1-1578 ENTPADLGLQVQGAPSPLSVQGQDSCPVSAAAPPKRPAPQRPPPPRLESRKHRTLISAPA ENSP00000370299/1-1616 DAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDA ENSMUSP00000098701/1-1487 --------------------------------SVLSSAQPQ----------DSQHVNEDT ENSRNOP00000056187/1-1491 --------------------------------SVLSSAQPQ----------DSQHVNEDP ENSCPOP00000009258/1-1385 --------------------------------SVLSSAQPQDTPKATACERDSQHVKEDV XP_004867441.1/1-1578 DPHPAGL-------PTTSLNAAVTCQSLSRSPSGFSSAQPQDAPKAAAC--DSQHVKEDT * :****** .****. * ENSP00000370299/1-1616 SRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDN ENSMUSP00000098701/1-1487 TFPQPETQLSSKCQH--LQTSAMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDN ENSRNOP00000056187/1-1491 TSPQPEAQLSSKCQH--LQTSTMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDN ENSCPOP00000009258/1-1385 LYPQPEALPSSKFQH--LRAFAMETSRSPSPQFAPQKLTDKPPLLIHDEHSTRIERVIDN XP_004867441.1/1-1578 PCPRPEALPSSKFRH--PQAFAMETSRSPSPQFAPQKLTDKPPLLIHDEHSTRIERVMDN * **: ..* :* :: :************************:::.*:*****:** ENSP00000370299/1-1616 NTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLY ENSMUSP00000098701/1-1487 NTTVKMVPIKIVHSESQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVY ENSRNOP00000056187/1-1491 NTTVKMVPIKIVHSESQPEKESRQSLACPAELPALPSGLEKDQIKTLSTSEQCYSRFCVY ENSCPOP00000009258/1-1385 NTTVKMVPIKIVHSESQPEKESRQSLVRLAELPALPRGLERDQIKTLSTSEQSYSRFCVY XP_004867441.1/1-1578 NTTVKMVPIKIVHSESQPEKESRQSLAHPAELPVLPSGLERDQIKTLSTSEQSYSRFCVY **************************. ** * ** ***:*********** *****:* ENSP00000370299/1-1616 TRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREI ENSMUSP00000098701/1-1487 TRQ--EVEAPHRARPPEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREI ENSRNOP00000056187/1-1491 TRQ--EVETPHRARPPEPQPPSTPAPPVRDSCSSPPSLNYGKAKEKTVDDLKSEELAREI ENSCPOP00000009258/1-1385 TRQ----------QPPVPQSSVPPMAPASDVCASPP-FSYAKTKEKTAEDLKSEELAREI XP_004867441.1/1-1578 TRQGPEAQAPPRARPPAPQPPGPPTAPALDLCASPPGLSYTKTKEKTAEDLKSEELARAI *** :*. *:. . .* * *:*** :.* *:**** :********* * ENSP00000370299/1-1616 VGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEERKEE ENSMUSP00000098701/1-1487 VGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQD ENSRNOP00000056187/1-1491 VGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPSPRVTEDKKQD ENSCPOP00000009258/1-1385 VGKDKSLADILDPSMKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRTSEEKKEE XP_004867441.1/1-1578 VGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRTTEEKEEE **************:*****************:**************:* ** :*::::: ENSP00000370299/1-1616 PSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQELIES ENSMUSP00000098701/1-1487 PGMPGVVSLATNSTYYSTSAPKAELLIKMKDL---QEPEEYSAGDLDHDLSVKKQELIDS ENSRNOP00000056187/1-1491 PGMPGVVSLATNSTYYSTSAPKAELLIKMKDL---QEPEEYSAGDLDHDLSIKKQELIDS ENSCPOP00000009258/1-1385 PMVLAAMSLATNSTYYSTSAPKAELLIKMKDLKQQQEPEEDSGSDLDHDLSLKKQELIDS XP_004867441.1/1-1578 PSVPAAVSLATNSTYYSTSAPKAELLIKMKGL-QQQEPEEDSGSDLDRDLSLKKQELIDS * : ..:***********************.* ** ** *..***:***:******:* ENSP00000370299/1-1616 ISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLL ENSMUSP00000098701/1-1487 ISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLL ENSRNOP00000056187/1-1491 ISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLL ENSCPOP00000009258/1-1385 IGRKLQVLREARESLLEDIQANNALGDEVEAVAKDVCKPNEFDKFRMFVGDLDKVVNLLL XP_004867441.1/1-1578 ISRKLQVLREARESLLEDIQANTALGDEVEAIAKDVCKPNEFAKFRMFIGDLDKVVNLLL *.****************:***..** ****:.*.****.** *****:*********** ENSP00000370299/1-1616 SLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVFDIL ENSMUSP00000098701/1-1487 SLSGRLARVENALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDIL ENSRNOP00000056187/1-1491 SLSGRLARVENALNNLDDSPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDIL ENSCPOP00000009258/1-1385 SLSGRLARVENALNNLEDSPSPGDRQSLLEKQKVLIQQHEDAKELKENLDRRERIVFDIL XP_004867441.1/1-1578 SLSGRLARVENALNNLEDSPSPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVFDIL ****************:*..************:** ************************ ENSP00000370299/1-1616 ANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK- ENSMUSP00000098701/1-1487 ATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK- ENSRNOP00000056187/1-1491 ATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK- ENSCPOP00000009258/1-1385 AAYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK- XP_004867441.1/1-1578 AAYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERAKV * *****.***********************************:*******.*