CLUSTAL W(1.81) multiple sequence alignment ENSP00000459943/1-1211 MPTPRDCGRLRSRAGRSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQ ENSMUSP00000118751/1-1169 ------------------------------------------MAEEEVAKLEKHLMLLRQ ENSRNOP00000021816/1-1169 ------------------------------------------FLAEEVAKLEKHLMLLRQ ENSCPOP00000005989/1-1169 ------------------------------------------FFAEEVAKLEKHLMLLRQ XP_004857636.1/1-1188 ------------------------MGERGGGMDHREARGSRGRQLKEVAKLEKHLMLLRQ :************** ENSP00000459943/1-1211 EYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRH ENSMUSP00000118751/1-1169 EYVKLQKKLAETEKRCTLLAAQANKENSNESFISRLLAIVAGLYEQEQYSDLKIKVGDRH ENSRNOP00000021816/1-1169 EYVKLQKKLAETEKRCTLLAAQANKENSSESFISRLLAIVAGLYEQEQYSDLKIKVGGRH ENSCPOP00000005989/1-1169 EYVKLQKKLAETEKRCTLLAAQANRESSSGSFISRLLTIVAELFEQEQYSDLKIKVGDRH XP_004857636.1/1-1188 EYVKLQKKLAETEKRCTLLAAQANKESSSESFISRLLTIVADLYEQEQYSDLKIKVGGRH ****************:*******:*.*. *******:*** *:*************.** ENSP00000459943/1-1211 ISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL ENSMUSP00000118751/1-1169 ISAHKFVLAARSDSWSLANLSSTEEIDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL ENSRNOP00000021816/1-1169 ISAHKFVLAARSDSWSLANLSSTAELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL ENSCPOP00000005989/1-1169 ISAHKFVLAARSDSWSLANLSSTEELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL XP_004857636.1/1-1188 ISAHKFVLAARSDSWSLANLSSTEELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL *********************** *:********************************** ENSP00000459943/1-1211 MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLR ENSMUSP00000118751/1-1169 MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLR ENSRNOP00000021816/1-1169 MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLR ENSCPOP00000005989/1-1169 MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLR XP_004857636.1/1-1188 MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLR ************************************************************ ENSP00000459943/1-1211 KEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDL ENSMUSP00000118751/1-1169 KEDFSSLSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNETDHNGDL ENSRNOP00000021816/1-1169 KEDFSSLSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNETDHNGDL ENSCPOP00000005989/1-1169 KEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEVDSQLPGKLNEVDHNGDL XP_004857636.1/1-1188 KEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEVDHNGDL ******:***********************************:**********.****** ENSP00000459943/1-1211 ALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA ENSMUSP00000118751/1-1169 ALDLALSRRLESIATTLVSHKADVDMVDKNGWSLLHKGIQRGDLFASTFLIKNGALVNAA ENSRNOP00000021816/1-1169 ALDLALSRRLESIATTLVSYKADVDMVDKNGWSLLHKGIQRGDLFASTFLIKNGALVNAA ENSCPOP00000005989/1-1169 ALDLALSRRLESIATTLVSHKADVDMVDKNGWSLLHKGIQRGDVFASTFLIKNGALVNAA XP_004857636.1/1-1188 ALDLALSRRLESIATTLVSHKADVDMVDKNGWSLLHKGIQRGDVFASTFLIKNGALVNAA *******************:*********.*************:**:********:**** ENSP00000459943/1-1211 TLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG ENSMUSP00000118751/1-1169 TAGAQETPLHLVALYSPKKYSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHLSIMAR ENSRNOP00000021816/1-1169 TVGAQETPLHLVALYSSKKYSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHLSIMAR ENSCPOP00000005989/1-1169 TLGAQETPLHLVALYSSKKHSAEEMSEMAQIAQALLQAGANSNMQDSKGRTPLHLSIMAR XP_004857636.1/1-1188 TLGAQETPLHLVALYTSKKHSAETMSEMAQIAEALLQAGANPNMQDSKGRTPLHLSIMAR * *************:.**:**: ********:********.************:**** ENSP00000459943/1-1211 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENS ENSMUSP00000118751/1-1169 NDCVFSQLLQCKQLDLELKDHEGSTALWLAVQYITVSSDQSVNPFEDLPVVNGTSFDENS ENSRNOP00000021816/1-1169 NEYVFNQLLQCKQLDLELKDHEGSTALWLAVQYITVSSDQSVNPFEDLPVVNGTSFDENS ENSCPOP00000005989/1-1169 NEYVFNQLLQCKQLDLDLKDHDGSTALWLAVQHITVTADQSVNPFEDLPVVNGTSFDENS XP_004857636.1/1-1188 NEYVFNQLLQCKQLDLELKDHEGSTALWLAVQYITVTSDQSVNPFEDLLVINGTSFDENS *: **.**********:****:**********:***::*********: *:********* ENSP00000459943/1-1211 FAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTA ENSMUSP00000118751/1-1169 FAARLIQRGSNTDAPDVMTGNCLLQRAAGAGNEAAALFLATSGAHANHRNKWGETPLHTA ENSRNOP00000021816/1-1169 FAARLIQRGSNTDAPDTMTGNCLLQRAAGAGNEAAALFLATSGAHANHRNKWGETPLHTA ENSCPOP00000005989/1-1169 FAARLIQCGSNTDAPDTATGNCLLQRAAGVGNEAAALFLAANGARVNHRNKWGETPLHTA XP_004857636.1/1-1188 FAARLIQCGSNTDAPDTVTGNCLLQRAAGAGNEAAALFLATNGAHVNHKNKWGETSLHTA ******* **:*****. ***********.**********:.**:.**:******.**** ENSP00000459943/1-1211 CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV ENSMUSP00000118751/1-1169 CRHGLANLTAELLQQGANPNLQTEEALPVPKESPVLMSSADSIYLQTPLHMAIAYNHPDV ENSRNOP00000021816/1-1169 CRHGLANLTAELLQQGANPNLQTEEALPVPKESPVLMGSADGIYLQTPLHMAIAYNHPDV ENSCPOP00000005989/1-1169 CRHGLANLTAELLQQGANPNLQTEEPVPFSKEATSLGGSVDSVYLQTPLHMAIAYNHPDV XP_004857636.1/1-1188 CQHGLANLTAELLQQGANPNLQTEEAVSLSKAAVSLTGSMDSVYLQTPLHMAIAYNHPDV *:***********************.:...* : * . *.::**************** ENSP00000459943/1-1211 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDT ENSMUSP00000118751/1-1169 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGASINDT ENSRNOP00000021816/1-1169 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGASINDT ENSCPOP00000005989/1-1169 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGASINDT XP_004857636.1/1-1188 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGASINDT *******************************************************:**** ENSP00000459943/1-1211 MSDGQTLLHMAIQRQDSKSALFLLEHQADINV-RTQDGETALQLAIRNQLPLVVDAICTR ENSMUSP00000118751/1-1169 MSDGQTLLHMAIQRQDSKSALFLLEHQADINV-RTQDGETALQLAIKHQLPLVVDAICTR ENSRNOP00000021816/1-1169 MSDGQTLLHMAIQRQDSKSALFLLEHQADINV-RTQDRETALQLAIKNQLPLVVDAICTR ENSCPOP00000005989/1-1169 MSDGQTLLHMAIQRQDSKSALFLLEHQADINV-RTQDGETALQLAIRNQLPLVVDAICTR XP_004857636.1/1-1188 MSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAMCTR ******************************** **** ********::********:*** ENSP00000459943/1-1211 GADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENN ENSMUSP00000118751/1-1169 GADMSVPDEKGNPPLWLALASNLEDIASTLVRHGCDATCWGPGPSGCLQTLLHRAVDENN ENSRNOP00000021816/1-1169 GADMSVPDEKGNPPLWLALASNLEDIASTLVRHGCDATCWGPGPSGCLQTLLHRAIDENN ENSCPOP00000005989/1-1169 GADMSVSDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPSGCLQTLLHRAIDENN XP_004857636.1/1-1188 GADMSVSDEKGDPPLWLALANNLEDIASTLVRHGCDATCWGPGPSGCLQTLLHRAIDENN ******.****:********.***********************.**********:**** ENSP00000459943/1-1211 EPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVN ENSMUSP00000118751/1-1169 ESTACFLIRSGCDVNSPRQPGTNGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVN ENSRNOP00000021816/1-1169 ESTACFLIRSGCDVNSPRQPGTDGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVN ENSCPOP00000005989/1-1169 ESTACFLIRSGCDVNSPRQPGADGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVN XP_004857636.1/1-1188 ESTACFLIRSGCDVNSPRQPGADGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVN *.*******************::************************************* ENSP00000459943/1-1211 AQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAIL ENSMUSP00000118751/1-1169 AQDAEGRTPVHVAISNQHSVIIQLLISHPNIELSVRDRQGLTPFACAMTYKNNKAAEAIL ENSRNOP00000021816/1-1169 AQDAEGRTAVHVAISNQHSVIIQLLISHPSIELSIRDRQGLTPFACAMTYKNNKAAEAIL ENSCPOP00000005989/1-1169 AQDAEGRTPVHVAISNQHSVIIQLLISHPDIHLNVRDRQGLTPFACAMTYKNNKAAEAIL XP_004857636.1/1-1188 AQDAEGRTPVHVAISNQHSVIIQLLISHPDIHLNVRDRQGLTPFACAMTYKNNKAAEAIL ********.:*****.**.******:***.*.*.:**************:****:***** ENSP00000459943/1-1211 KRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG ENSMUSP00000118751/1-1169 KRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVQANVNSRVQDASKLTPLHLAVQAG ENSRNOP00000021816/1-1169 KRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVQANVNSRVQDATKLTPLHLAVQAG ENSCPOP00000005989/1-1169 KRESGAAEQVDNKGRNFLHIAVQNSDIESVLFLISVQANVNSRVQDASKLTPLHLAVQAG XP_004857636.1/1-1188 KRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG *******************:****************:**********:************ ENSP00000459943/1-1211 SEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALH ENSMUSP00000118751/1-1169 SEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALH ENSRNOP00000021816/1-1169 SEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALH ENSCPOP00000005989/1-1169 SEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENAVDFAAVDENGNNALH XP_004857636.1/1-1188 SEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENAVDFAAVDENGNNALH ********************************************.*************** ENSP00000459943/1-1211 LAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPL ENSMUSP00000118751/1-1169 LAVMHGRLNNIRALLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPEYPL ENSRNOP00000021816/1-1169 LAVMHGRLNNIRALLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPEYPL ENSCPOP00000005989/1-1169 LAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGRENAAAIFDLFLECMPEYPL XP_004857636.1/1-1188 LAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPEYPL ************.***************************:*************** *** ENSP00000459943/1-1211 DKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDM ENSMUSP00000118751/1-1169 DKPDAEGNTVLLLAYMKGNANLCRAIVRSGVRLGVNNNQGVNIFNYQVATKQLLFRLLDM ENSRNOP00000021816/1-1169 DKPDAEGNTVLLLAYMKGNANLCRAIVRSGVRLGVNNNQGVNIFNYQVATKQLLFRLLDM ENSCPOP00000005989/1-1169 DKPDSEGNTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDM XP_004857636.1/1-1188 DKPDTEGNTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDM ****::*.**********************.***************************** ENSP00000459943/1-1211 LSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCN ENSMUSP00000118751/1-1169 LSKEPPWCDGSNCYECTAKFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCN ENSRNOP00000021816/1-1169 LSKEPPWCDGSNCYECTAKFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCN ENSCPOP00000005989/1-1169 LSKEPPWCDGSNCYECTAKFGVTTRKHHCRHCGRLLCHKCSTKEMPIIKFDLNKPVRVCN XP_004857636.1/1-1188 LSKEPPWCDGSNCYECTAKFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCN *********** ******:*************************:*************** ENSP00000459943/1-1211 ICFDVLTLGGVS ENSMUSP00000118751/1-1169 ICFDVLTLGGVS ENSRNOP00000021816/1-1169 ICFDVLTLGGVS ENSCPOP00000005989/1-1169 ICFDVLTLGGVS XP_004857636.1/1-1188 ICFDVLTLGGVS ************