CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000072871/1-1506 -MALQDLGENLQPWCPLGLSLEWVKTVWDLDFTEIEPLDPSIVGEILETGRDAFTKLYGS ENSRNOP00000012078/1-1494 -MALKDLGRDLQPWCPLDLSLEWVNTVWDLDFTETEPLDPSVVAEILETGRDAFTKLYGS ENSCPOP00000005889/1-1508 MVALRGLGSSLQPWCPVDLSPEWVDTVWELDFTETEPLDSSIEAQIIETELSAFTNLYES ENSP00000433681/1-1498 MVALRGLGSGLQPWCPLDLRLEWVDTVWELDFTETEPLDPSIEAEIIETGLAAFTKLYES XP_004862725.1/1-1495 MVALRDLGSGLQPWCPLDLNPEWVDTVWELDFTETEPLDSSIEAQIIETGLSAFTKLYES :**:.** .******:.* ***.***:***** ****.*: .:*:** ***:** * ENSMUSP00000072871/1-1506 LFPFATDESGSLESIWTFFTENDISSNTLVALFCHFVQEAHKKSASAQYREYGLHAAGLY ENSRNOP00000012078/1-1494 LFPFATDESGSLESVWSFFTENSISSNTLVALFCHFVQEAHKKSASVQYREYGLRAAGLY ENSCPOP00000005889/1-1508 LFPFATEECGYSESIWTFFTENSISHSTLVALFHHFVQIVHKKNISVQYRKYGLHAAGLY ENSP00000433681/1-1498 LLPFATGEHGSMESIWTFFIENNVSHSTLVALFYHFVQIVHKKNVSVQYREYGLHAAGLY XP_004862725.1/1-1495 LFPFAIEECGSSENVWTFFIENSISYSTLVALFYHFVQVVHKKNVSVKYREYGLHAAGLY *:*** * * *.:*:** **.:* .****** **** .***. *.:**:***:***** ENSMUSP00000072871/1-1506 FLLLEIPGSVVNQVFHPVMFDKCIQILKRSWPQESNLTQKRKKDHSKSSKDNYRKSRKRG ENSRNOP00000012078/1-1494 FLLLEIPGSVVNQVFHPVMFDKCIQILKKSWPQESNLTQKRKKEHSKSSKANYRRSRKRG ENSCPOP00000005889/1-1508 FLLLEIPGSVANQVFHPVMFDKCIQILKKSWPQESNLNRKRKKEQPQSSQVNSKGSRKRG ENSP00000433681/1-1498 FLLLEVPGSVANQVFHPVMFDKCIQTLKKSWPQESNLNRKRKKEQPKSSQANPGRHRKRG XP_004862725.1/1-1495 FLLLEIPGSVANQVFHPVMFDKCIQILKKSWPQESKLNRKRKKEQPRSSQVNSRGNRKRG *****:****.************** **:******:*.:****::.:**: * **** ENSMUSP00000072871/1-1506 KPPRKEDYQVDELS-REEEEEEEEIYFSGRDLCQIRDAIFNLLKNFLRLLPKFSLKEKPQ ENSRNOP00000012078/1-1494 KPPRKEDYQVDELSREEEEEEEEEIYFSVRDLSQIRDAIFNLLKNFLRLLPKFSLKEKPQ ENSCPOP00000005889/1-1508 KPHRKDVAEMDEII-EEEEDDEENIYFSAQDLSQIRNAILHLLKNFLRLLPKFSLKEKPQ ENSP00000433681/1-1498 KPPRREDIEMDEII---EEQEDENICFSARDLSQIRNAIFHLLKNFLRLLPKFSLKEKPQ XP_004862725.1/1-1495 KPPRKEDSEMVEII-EEEEGDEENIYFSARDLSQIRNAVFDLLKNFLRLLPRFSLKEKPQ ** *:: :: *: ** ::*:* ** :**.***:*::.**********:******** ENSMUSP00000072871/1-1506 SIQTCIEVFVALTSFEPIPHKFLISQARNLNEVKHISELAYYGLYLLCSPVHGEENKVIG ENSRNOP00000012078/1-1494 SIQTCIEVFVALTSFEPIPHKFLISQARNLSEVKHISELAYYGLYLLCSPVHGEGNKVIG ENSCPOP00000005889/1-1508 CVQTCIEVFVALTSFEPVLHEFHVIQARNLSQTKYIPELAYYGLYLLCSPFHGEGDKVIG ENSP00000433681/1-1498 CVQNCIEVFVSLTNFEPVLHECHVTQARALNQAKYIPELAYYGLYLLCSPIHGEGDKVIS XP_004862725.1/1-1495 CVQTCIEVFVALTSFEPVLHEFHVTQARNLTQAKYIPELAYHGLYLLCSPVHGEGDKVIG .:*.******:**.***: *: : *** *.:.*:*.****:********.*** :***. ENSMUSP00000072871/1-1506 SIFHQMLNVILMLEVGEGSRCAPLAITSQVINCRNQAVQFVSSLVDELQASVYPVLGTLL ENSRNOP00000012078/1-1494 SIFHQMLNVILMLEVGEGSRCAPLAITSHVINCRNQAVQFVSSLVDELQESVFPILGTLL ENSCPOP00000005889/1-1508 YIFHRMLNVLLMLEVGEGSYHPPLTITAQVINRKNQAVQFISSLVDELKESIFPVLRILL ENSP00000433681/1-1498 CVFHQMLSVILMLEVGEGSHRAPLAVTSQVINCRNQAVQFISALVDELKESIFPVVRILL XP_004862725.1/1-1495 CIFHQMLNVILMLEVGEGSLHTPLTITSQVISRKNQAVQFISSLVDELKENIFPVLRILL :**:**.*:********* .**::*::**. :******:*:*****: .::*:: ** ENSMUSP00000072871/1-1506 QHICAKVVDKAEYRTYAAQSLVQLLTKLPSEEYATFIAWLYKYSRSSKIPHRVFTLDVAL ENSRNOP00000012078/1-1494 QHICAKVVDKAEYRTYAAQSLVQLLSKLPSKEYATFIAWLYKYSRSSKIPHRVFTLDVAL ENSCPOP00000005889/1-1508 QHICAKVTDKSEYRTSAAQSLVHLLGKLPSGEYAMFISWLYKYSQSSKIAHRVFTLDVVL ENSP00000433681/1-1498 QHICAKVVDKSEYRTFAAQSLVQLLSKLPCGEYAMFIAWLYKYSRSSKIPHRVFTLDVVL XP_004862725.1/1-1495 QHICAKVTDKSEYRTSAAQSLVHLLSKLPCGEYATFISWLYKYSRSSKIAHRVFTLDVVL *******.**:**** ******:** ***. *** **:******:****.********.* ENSMUSP00000072871/1-1506 ALLTLPERELDDTVSLEHQKFLKHKFFVQEIIFDRCLDKAPTVRSKALSSFAHCLELSSS ENSRNOP00000012078/1-1494 ALLELPERLLDDTVLLEHQKFLKHKFFVQEIIFDRCLDKAPTVRSKALSSFAQCLELSTS ENSCPOP00000005889/1-1508 ALLELPEREVDGTVSLEQQRFLRHRFLVQEIMFDRCLDKAPTVRSKALSSFARCLELSAH ENSP00000433681/1-1498 ALLELPEREVDNTLSLEHQKFLKHKFLVQEIMFDRCLDKAPTVRSKALSSFAHCLELTVT XP_004862725.1/1-1495 ALLELPERVVDGTLSLEHQKFLRHKFLVQEIMFDRCLDKAPTVRSKALSSFAHCLELSVH *** **** :*.*: **:*:**:*:*:****:********************:****: ENSMUSP00000072871/1-1506 NTSESILEIFINSNLVPGIQ-NLSNTVLNPSPVLT------SRNGYSAQSRTHNNDEQTL ENSRNOP00000012078/1-1494 NTSENTLEIFINS-TVTGIH-SHFGTSLRPSTVLT------SQSCRSVQSSTHDSDEQTP ENSCPOP00000005889/1-1508 GTSESILELLINNKLTPLVDKCLSYHVLNPSNIKL------SRTGNWREVRGHSNVYSTL ENSP00000433681/1-1498 SASESILELLINSPTFSVIE-SHPGTLLRNSSAFSYQRQTSNRSEPSGEINIDSSGETVG XP_004862725.1/1-1495 NTSESILELLINSPTVSDTG-IHPGTLLRNSSAFSCQRQTFNPSEPAGEINTDSSGHIVG .:**. **::**. . *. * . . : ... . ENSMUSP00000072871/1-1506 PGERCFMTMLRKRIKDEKINVRKSALQVLMSILKHCDILSMEQDLLILQDHCRDPAISVR ENSRNOP00000012078/1-1494 PGERRFMTMLRKRTKDEKINVRKSALQVLMSILKHCDILSMEEDLLILQDHCRDPAISVR ENSCPOP00000005889/1-1508 LTEGYVMTMLRKRIQDEKTNVRKSALQVLVTILKHCDILSMEEDLTILQDHCRDPAVSVR ENSP00000433681/1-1498 SGERCVMAMLRRRIRDEKTNVRKSALQVLVSILKHCDVSGMKEDLWILQDQCRDPAVSVR XP_004862725.1/1-1495 SRDRCVLAMLRKRIRDEKTNVRKSALQVLVSILKHCDILGMEEDLTILQDHCRDPAVSVR : .::***:* :*** **********::******: .*::** ****:*****:*** ENSMUSP00000072871/1-1506 KQALQSLTELVMAQPTCVPVQKAWLMGVIPVVMDCESTVQEKALECLDQLLLQNIKHHKK ENSRNOP00000012078/1-1494 KQALQSLTELVMAKPTCVPVQKAWLMGVIPVVMDYESTVQEKALECLDQLLLQNIKHHRK ENSCPOP00000005889/1-1508 KQALQSLTELLMAQPKYVTLQKAWLMGVIPMVMDSESTVQEKALECLDQLLLQNIKHHSK ENSP00000433681/1-1498 KQALQSLTELLMAQPRCVQIQKAWLRGVVPVVMDCESTVQEKALEFLDQLLLQNIRHHSH XP_004862725.1/1-1495 KQALQSLTELLMAQPRCVLIQKAWLSGVIPVVMDCESTVQEKALEYLDQLLLQNIKHHSK **********:**:* * :***** **:*:*** ********** *********:** : ENSMUSP00000072871/1-1506 FHSADRSQVLAWSLLALLTIENQDLRRYLNKAFHIWSKKDKFSSTFINSVISHTDTERSA ENSRNOP00000012078/1-1494 FHSEDRSQVLAWALLALLTVESQDLSRYLNKAFHIWSKKDKFSSTFINSVISHTDTERSA ENSCPOP00000005889/1-1508 FHREDESQVLAWALLTLLTTESQDMSRYLNKAFHIWSKKDKFSSTFVNNTISHTDTERAA ENSP00000433681/1-1498 FHSGDDSQVLAWALLTLLTTESQELSRYLNKAFHIWSKKEKFSPTFINNVISHTGTEHSA XP_004862725.1/1-1495 FHIEDDSQVLAWSLLALLTTEGQELSRYLNKAFHIWSKKDKFSSTFINNMLSHTGTEHSA ** * ******:**:*** *.*:: *************:***.**:*. :***.**::* ENSMUSP00000072871/1-1506 PAWMLLSKITCSSPKLDYTKIIESWERLSREQSPNSNTLGYMLCVIGHIAKHLPKGTRDK ENSRNOP00000012078/1-1494 PAWMLLSKITCSSPKLDYTKIMESWEKLSREQSPNSNTLGYMLCVIGHIAKHLPKSTQDK ENSCPOP00000005889/1-1508 PAWMLLSKIAGSAPTLNYTKVLQSWETLSSQQNPNSNTLGHILCVIGRTAKHLPESTRER ENSP00000433681/1-1498 PAWMLLSKIAGSSPRLDYSRIIQSWEKISSQQNPNSNTLGHILCVIGHIAKHLPKSTRDK XP_004862725.1/1-1495 PAWMLLSKIAGSSPKLDYTKIMWSWEKISSQQNPNSNTLGHILCVIGHIAKHLPESTRDR *********: *:* *:*:::: *** :* :*.*******::*****: *****:.*::: ENSMUSP00000072871/1-1506 ITGVIKAKLNGFQWSPELISSSVDALQKLCRASAKTVLEEQGLLKQVCGDVLATCEQHLS ENSRNOP00000012078/1-1494 ITGVIKAKLNGFQWSLELISLSVDTLQGLCRASAKTLREEQELLKRVCGDVLSTCEQHLS ENSCPOP00000005889/1-1508 VADVIKCKLSGFQWSLGLISPAVDTLQSLCRASAKTLMEEQDLLKRVCGDVLSTCEQQLS ENSP00000433681/1-1498 VTDAVKCKLNGFQWSLEVISSAVDALQRLCRASAETPAEEQELLTQVCGDVLSTCEHRLS XP_004862725.1/1-1495 VTDVIKYKLNGFQWSLELITSAVDTLQSLCRASAKTAMEEQELLKQVCGDVLSTCQHHLS ::..:* **.***** :*: :**:** ******:* *** **.:******:**:::** ENSMUSP00000072871/1-1506 NILLKEDGTGNMDEGLVVKCIFTLGDIAQLCPAIVEKRVFLLIQSILASSAHSDHLPSSQ ENSRNOP00000012078/1-1494 NILLKEDGTGNMDEDLVVKCIFTLGDIAQLCPALVEKRVFLLIQSILASSAHADHLPSSQ ENSCPOP00000005889/1-1508 NIVLKEDRAESLDKDLLVKYIFTLGDIAQLCPARVEKRVFLMIQSILASSADADHLLPSQ ENSP00000433681/1-1498 NIVLKENGTGNMDEDLLVKYIFTLGDIAQLCPARVEKRIFLLIQSVLASSADADHSPSSQ XP_004862725.1/1-1495 NIILKEDGAGNMDEDLLVKYIFTLGDVAQLCPARVEKQVFLLIQSILASSADADHLLPSQ **:***: : .:*:.*:** ******:****** ***::**:***:*****.:** .** ENSMUSP00000072871/1-1506 GTTDALD-SQPPFQPRSSAMPSVIRAHAIITLGKLCLQHEDLAKKSIPALVRELEVSEDV ENSRNOP00000012078/1-1494 GTTD-LA-SQLPFQARSSALPSVIRAHAIITLGKLCLQHEDLAKKSIPALVRELEVCEDV ENSCPOP00000005889/1-1508 GSSDAPASSQPPSWVKRTVMPSVIRAHAIITLGKLCLQHEDLAKKSVPALVRELEVCEDV ENSP00000433681/1-1498 GSSEAPA-SQPPPQVRGSVMPSVIRAHAIITLGKLCLQHEDLAKKSIPALVRELEVCEDV XP_004862725.1/1-1495 GSGEAPT-TQLPSKVRSFVMPSVIRAHAIITLGKLSLQHEDLAKKSIPALVRELELCEDV *: : :* * : .:***************.**********:********:.*** ENSMUSP00000072871/1-1506 AVRNNVIIVICDLCIRYTVMVDNYIPNISVCLKDSDPFIRKQTLVLLTNLLQEEYVKWKG ENSRNOP00000012078/1-1494 AVRNNVIIVMCDLCIRYTVMVDNYIPNISICLKDSDPFIRKQTLILLTNLLQEEYVKWKG ENSCPOP00000005889/1-1508 AVRNNVVIVLCDLCIRYPVMVDKYIPYVAMCLKDSDPFIRKQTLILLTNLLQEEFVKWKG ENSP00000433681/1-1498 AVRNNVIIVMCDLCIRYTIMVDKYIPNISMCLKDSDPFIRKQTLILLTNLLQEEFVKWKG XP_004862725.1/1-1495 AVRNNVIIVLCDLCIRYTVMVDKYIPHISMCLKDPDPFIRKQTLILLTNLLQEEFVKWKG ******:**:*******.:***:*** :::****.*********:*********:***** ENSMUSP00000072871/1-1506 SLFFRFVSTLVDSHPDIASLGEFCLAHLLLKRNPTMFFQHFIECIFHFNSYEKHGQYNKF ENSRNOP00000012078/1-1494 SLFFRFVSTLVDSHPDIASLGEFCLAHLLLKRNPTMFFQHFIECIFHFNSYEKHGQYNKF ENSCPOP00000005889/1-1508 SLFFRFVSTLIDSHPDVASFGEFCLAHLLLKRNPVMFFQHFIECIFHFNNYEKHEKYNKF ENSP00000433681/1-1498 SLFFRFVSTLIDSHPDIASFGEFCLAHLLLKRNPVMFFQHFIECIFHFNNYEKHEKYNKF XP_004862725.1/1-1495 SLFFRFVSTLIDSHPDIASFGEFCLAHLLLKRNPVMFFQHFIECIFHFNSYEKHEKYNKF **********:*****:**:**************.**************.**** :**** ENSMUSP00000072871/1-1506 SQSERGKQLFLLKGKTNKEKRMRIYKFLLEHFTDEQRFNVTSKICLNILACFTDGILPMD ENSRNOP00000012078/1-1494 SQSERGKPLFLLKGKTNKEKRMRIYKFLLEHFTDEQRFNVTSKICLNILACFTDGVLPVD ENSCPOP00000005889/1-1508 PQSEREKKLFSLKGKTNKGNRMKIYKFLLEHFTDEQRFNITSKICLSILACFADGVLPVD ENSP00000433681/1-1498 PQSEREKRLFSLKGKSNKERRMKIYKFLLEHFTDEQRFNITSKICLSILACFADGILPLD XP_004862725.1/1-1495 PQSEREKQLFSLKGKTNKESRMKIYKFLLEHFTDEQRFNITSKICLSILACFADGILPLD .**** * ** ****:** **:****************:******.*****:**:**:* ENSMUSP00000072871/1-1506 MEASELLSDTFDILNSKEIKLLAMRAQTSKD--LLEEDDVALANVVMQEAQMKIISQVQK ENSRNOP00000012078/1-1494 MEASELLSDTFDILSSKEIKLLAMRAQASKE--LLEEDDVALANVVMQEAQMKIISQVQK ENSCPOP00000005889/1-1508 MEASELLSDTFEVLSSKEIKLLAMRAKSDKD-LLFEEDEVALADVVMQEAKKQLISQVQK ENSP00000433681/1-1498 LDASELLSDTFEVLSSKEIKLLAMRSKPDKD-LLMEEDDMALANVVMQEAQKKLISQVQK XP_004862725.1/1-1495 MEASELLSDTFEVLSSKEIKLLAMRAKPDKDILLLEEDNVALANIVMQEAQKQLISQVQK ::*********::*.**********::..*: *:***::***::*****: ::****** ENSMUSP00000072871/1-1506 RNFIENIIPIIISLKTVLEKNKIPALRELMNYLREVMQDYRDEINDFFAVDKQLASELEY ENSRNOP00000012078/1-1494 RNFIENIIPIIISLKTVLEKNKIPALRELMNYLREVMQDYRDEIKDFFAVDRQLASELEY ENSCPOP00000005889/1-1508 RNFIENIIPLIISLKTMLEKNKIPALRELMYYLREVMQDYQDEVKDFFAVDKQLASELEY ENSP00000433681/1-1498 RNFIENIIPIIISLKTVLEKNKIPALRELMHYLREVMQDYRDELKDFFAVDKQLASELEY XP_004862725.1/1-1495 KNFIENIIPIIISLKTILEKNKIPALRELMYYLREVMQDYRDEVKEFFAVDKQLASELEY :********:******:************* *********:**:::*****:******** ENSMUSP00000072871/1-1506 DMKKYNEQLAQEQALTEHANATKGPEDSDRVPSAQVAPDLEAVPALAAAPMAAAAAAAPM ENSRNOP00000012078/1-1494 DMKKYTEQLAQEQALTEHANATNVPADGDRVPSQQVAPDLQAVPG--------------- ENSCPOP00000005889/1-1508 DMKKYNEQLAQEQELARHAEADRAAHSDARAPATQSAP-LQTQGLLGLAPAHARSVAPGL ENSP00000433681/1-1498 DMKKYQEQLVQEQELAKHADVAGTAGGAEVAPVAQVALCLETVPV--------------- XP_004862725.1/1-1495 DMKKYSEQLAQERELAKHAEARRAADSDTGAQAMQVIPGLEVMPA--------------- ***** ***.**: *:.**:. . . . * *:. ENSMUSP00000072871/1-1506 AAAAAAAGQDNADV--PPTQSRPSAPRSNFTPTL--PPISENGPLK-IMSSTRPMSLSTI ENSRNOP00000012078/1-1494 AAAAAGAGQADANMPLPLAQSQPSAPGSSFTPTL--PPICEKGPLK-IMSSTRPMSLSTI ENSCPOP00000005889/1-1508 EAASAATGQKPAE---SPGTSRPSAAGPSTDDML------ERGPPRMLLPGAKRMSLSTI ENSP00000433681/1-1498 -----PAGQENPAM--SPAVSQPCTPRASAGHVAVSSPTPETGPLQRLLPKARPMSLSTI XP_004862725.1/1-1495 -----PVSQKPATV--SPATSQPSAPESSTGHML------ETGPPKMLMPGARPMSLSTI ..* . . *:*.:. .. * ** : ::. :: ****** ENSMUSP00000072871/1-1506 AILNSVKKAVASKN--RTRSLGALPFNVETGSPENPSSHESSLSLEKESDRTVNHVTKRA ENSRNOP00000012078/1-1494 AILNSVKKAVASKS--RTRSLGALSFNMENGSPENPSSRASSLSLEQESERAVKRVTKRA ENSCPOP00000005889/1-1508 AILNSVKKAVESKNKHRNRSMGIPPFSLGSESQEKPSSRVSSCSLERELNGSTDWVATRA ENSP00000433681/1-1498 AILNSVKKAVESKSRHRSRSLGVLPFTLNSGSPEKTCSQVSSYSLEQESNGEIEHVTKRA XP_004862725.1/1-1495 AILNSVKKAVESKSRHRSRSVGVLPFSLSSGSPGKPTSNASPYNLERETDGSMDWITKRA ********** **. *.**:* .*.: . * :. *. *. .**:* : . ::.** ENSMUSP00000072871/1-1506 ISTPENSISDVTFAAGVSYIGTPAT-FFTKEK-HEAQEQGSDILCLSLLDKRPPQSPQWN ENSRNOP00000012078/1-1494 ISTPEKSISNVTFGAGVSYIGTPATSFFTKEKPEEAQEEGNDILCLSLLDKRPPQSPQWN ENSCPOP00000005889/1-1508 VSTPQQPLSEVTFGAGLSYIETSQTPLPAKDK-SKAQRQGTDILCLSLPDKPSTQPSQWK ENSP00000433681/1-1498 ISTPEKSISDVTFGAGVSYIGTPRTPSSAKEK-IEGRSQGNDILCLSLPDKPPPQPQQWN XP_004862725.1/1-1495 ISTPERSISEVTFGAGVSYIETSQTPLPAKDK-IEAQNQGNDILCLSLPDKPPAQPQQWN :***:..:*:***.**:*** *. * :*:* :.: :*.******* ** ..*. **: ENSMUSP00000072871/1-1506 VKSPARSHGSTRSSRRSLRKAPLKTAN ENSRNOP00000012078/1-1494 VKSPARSQDNPRSGRRSLRKAPLKTAN ENSCPOP00000005889/1-1508 VTSPARRKGSPALSKRSLCEAPLKTAN ENSP00000433681/1-1498 VRSPARNKDTPACSRRSLRKTPLKTAN XP_004862725.1/1-1495 VMSPARNKGNPVPSRRSIRKAPLKTAN * **** :... .:**: ::******