CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000004517/1-887 --------------------------------WLQVVKILEKHDPLKNSQARYGAIPPDE ENSMUSP00000113235/1-1081 MMSSVSTESKLQQAVSLKGVDPETCMIVFKNHWAQVVKILEKHDPLKNTQAKYGSIPPDE ENSRNOP00000064685/1-663 ------------------------------------------------------------ XP_004869232.1/1-1041 MMSSVSTESKLQQAVSLQGVDPETCMIVFRNHWAQVIKILEKHDPLKNSQAKYGSIPPDE ENSP00000421580/1-1040 MMSSVSTESKLQQAVSLQGVDPETCMIVFKNHWAQVVKILEKHDPLKNTQAKYGSIPPDE ENSCPOP00000004517/1-887 ASAVQNYVEHMLFLLIEEEAKDAAMGPILEFVVSENIMEKLFLWSLRREFTDETKIEQLK ENSMUSP00000113235/1-1081 ASAVQNYVEHMLFLLIEEQAKDAAMGPILEFVVCENIMEKLFLWSLRREFTDETKLEQLK ENSRNOP00000064685/1-663 ------------------------------------------------------------ XP_004869232.1/1-1041 ASAVQNYVEHMLFLLIEEQAKDAAMGPILEFVVSENIMEKLFLWSLRREFTDETKIEQLK ENSP00000421580/1-1040 ASAVQNYVEHMLFLLIEEQAKDAAMGPILEFVVSENIMEKLFLWSLRREFTDETKIEQLK ENSCPOP00000004517/1-887 MYEMLVTQSHQPLLHHKPILKPLMMLLSSCSGTTTPAVERKLVVLLNQLCSILAKDPSIL ENSMUSP00000113235/1-1081 MYEMLVTQSYQPLLHHKPILKPLMMLLSSCSGTATPAVEGKLVVLLNQLCSILAKDPSIL ENSRNOP00000064685/1-663 -----------------------MMLLSSCSGTATPAVEGKLVVLLNQLCSILAKDPSIL XP_004869232.1/1-1041 MYEMLVTQSHQPLLHHKPILKPLMMLLSSCSGTTTAAVEGKLVVLLNQLCSILAKDPSIL ENSP00000421580/1-1040 MYEMLVTQSHQPLLHHKPILKPLMMLLSSCSGTTTPTVEEKLVVLLNQLCSILAKDPSIL **********:*.:** ******************** ENSCPOP00000004517/1-887 ELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSMVAHHIVENT ENSMUSP00000113235/1-1081 ELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSMVANHIVENT ENSRNOP00000064685/1-663 ELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSMVANHIVENT XP_004869232.1/1-1041 ELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSMVAHHIVENT ENSP00000421580/1-1040 ELFFHTSEDQGAANFLIFSLLIPFIHREGSVGQQARDALLFIMSLSAENTMVAHHIVENT *****************************:*******************:***:****** ENSCPOP00000004517/1-887 YFCPVLATGLSGLYSSLPTKLEEKGEEWHCLLKDDWLLLPALVQFMNSLEFCNAVIQVAH ENSMUSP00000113235/1-1081 YFCPVLATGLSGLYSSLPTKLEEKGEDWHCILKDDWLLLPALVQFMNSLEFCNAVIQVAH ENSRNOP00000064685/1-663 YFCPVLATGLSGLYSSLPTKLEEKGEEWHCLLKDDWLLLPALVQFMNSLEFCNAVIQVAH XP_004869232.1/1-1041 YFCPVLATGLSGLYSSLPTKLEEKGEEWHCLLKDDWLLLPPLVQFMNSLEFCNAVIQVAH ENSP00000421580/1-1040 YFCPVLATGLSGLYSSLPTKLEEKGEEWHCLLKDDWLLLPSLVQFMNSLEFCNAVIQVAH **************************:***:*********.******************* ENSCPOP00000004517/1-887 PLIRRQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLETFLRFIL ENSMUSP00000113235/1-1081 PLIRTQLVSYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFIL ENSRNOP00000064685/1-663 PLIRTQLVSYIYNGFLVPVLAPALHK---------------------------------- XP_004869232.1/1-1041 PLIRHQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFIL ENSP00000421580/1-1040 PLIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFIL **** ***.***************** ENSCPOP00000004517/1-887 LHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLVLRYLIPCNHMMLS ENSMUSP00000113235/1-1081 LHRHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLVLRYLVPCNHMMLS ENSRNOP00000064685/1-663 ----------------------LCVVSLALFRTLIGLHCEDVMLQLVLRYLVPCNHMMLS XP_004869232.1/1-1041 LHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLVLRYLIPCNHMMLS ENSP00000421580/1-1040 LHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLVLRYLIPCNHMMLS *****************************:******** ENSCPOP00000004517/1-887 QRWAVKERDCYSVSAAKLLALTPGCCASGITVTLGDQERDYILWSKGMPDGSDSSNYCET ENSMUSP00000113235/1-1081 QRWAVKERDCYSVSAAKLLALTPVCCASGITLTLGNQERDYILWSKCMHDGSGSEE---- ENSRNOP00000064685/1-663 QRWAVKERDCYSVSAAKLLALTPVCCASGITLTLGNQERDYILWSKCMHDGSGPEE---- XP_004869232.1/1-1041 QRWAVKERDCYSVSAAKLLALTPSCCASGITLTLGHQERDYVLWSECTHDGSGPAE---- ENSP00000421580/1-1040 QRWAVKERDCYSVSAAKLLALTPVCCSSGITLTLGNQERDYILWSKCMHDTSGPVE---- *********************** **:****:***.*****:***: * *.. : ENSCPOP00000004517/1-887 GTPLSLCVMSTHPLKGSPGPTEPPPEAASPSACIVEYGKALDISYLQYLWEAHTNILRCM ENSMUSP00000113235/1-1081 -QLL--------PETPCSPSSPSPPPPPAPAACIVEYGKALDISYLQYLWEAHTNILHCM ENSRNOP00000064685/1-663 -QPL--------PETPCSPSSPPPPPQPAPAACIVEYGKALDISYLQYLWEAHTNILHCM XP_004869232.1/1-1041 --PL--------------------PETPLPSACIVERGKALDISYLQYLWEAHTNILCCM ENSP00000421580/1-1040 -RPF--------------------PEAFSESACIVEYGKALDISYLQYLWEAHTNILRCM : * :***** ******************** ** ENSCPOP00000004517/1-887 QDCRVWSALYDGDSPSSETLLPGLPE------ASPMSQHPQH------------------ ENSMUSP00000113235/1-1081 RDCRVWSALYDGDSPDPETFLQSLSEESRENSGHPEARLPQQSVRTSGQ----TKDKSQS ENSRNOP00000064685/1-663 RDCRVWSALYDGDSPDPETFLQSLSEESRENSSHPEARLSQQCIRTSGQ----TKDKSQS XP_004869232.1/1-1041 RDCRVWSALYDGDSPSSETFLCSLREDGPVRSVCLGSQLPQHL-GKGGSQLTPAKDKGQT ENSP00000421580/1-1040 RDCRVWSALYDGDSPDPEMFLQSLTEEGSVSSACPVFGLPQQLPRKTGPQLAPRKDKSQT :**************..* :* .* * .*: ENSCPOP00000004517/1-887 --------------------PG-------------------------------------- ENSMUSP00000113235/1-1081 ELEWDDSYDTGISSGADVGSPGPDDEVETPAPPAPIDPPKHIQEMKKNAILLFKGSYIEE ENSRNOP00000064685/1-663 ELEWDDSYDTGISSGADVGSPGPYDDVETPAPPAPIDPPKHIQEMKKNAILLFKGSYIEE XP_004869232.1/1-1041 ELEWDDSYDTGISSGADAGSPGAYDDLETSGPPVPVDPPKHIQEMKKNAILLFKGSYIEE ENSP00000421580/1-1040 ELEWDDSYDTGISSGADVGSPGPYDDLEVSGPPAPIDPPKHIQEMKKNALLLFKGSYIEE ** ENSCPOP00000004517/1-887 -----------LCAEKDTEDTK-------------------------------------- ENSMUSP00000113235/1-1081 SDFQDDVMVYRLCAEKDTEDTTEPQKDTSEPQGDTLEPLEDTSEQQEDTSEQLEDTSELQ ENSRNOP00000064685/1-663 SDFQDDVMVYRLCAEKDAEDTR-------------------------------------- XP_004869232.1/1-1041 SDFQDDVMVYRLCAEKDAEEAR-------------------------------------- ENSP00000421580/1-1040 SDFQDDVMVYRLCAEKDSEDMK-------------------------------------- ******:*: ENSCPOP00000004517/1-887 ----DSQGEVLERSGTG-------MGGSPT---PVVVLAPAL------------------ ENSMUSP00000113235/1-1081 EDTAEPQGDTADPTAEAQPKLQPEAQSLPTSNGPLSSPDPETESQP--SRESSDLCQNTF ENSRNOP00000064685/1-663 ----EPQGATTDPPAEAQPKAQPEAQSLPTSNGPLFSPNPEAESKP--GRESSDLCQNMF XP_004869232.1/1-1041 ----DSQEEAARPPPEA----QPEVHSSPVNSRPL-SPPPELDSEGEHKMDNSDLFQKMS ENSP00000421580/1-1040 ----DSQEEAARPPAEA----QAEVQSVPINNGPLLSTQPETDSEEEWNRDNSDPFHSEP :.* . . . . * *: * ENSCPOP00000004517/1-887 --------PGAWPAPAFCSLLGTLAPDNAVRLLIWGAHMHMCGTMGQGPELLRSIENGG- ENSMUSP00000113235/1-1081 SEAKPENEPGV--ALALDSELIATTFEAEPQSELAVVSTESEDFIAQYDQIIQELDSGTE ENSRNOP00000064685/1-663 SEAKPESEPGV--ALDSDSELTVPTFEAEPQSDSPVASTEGEDFIAQYDQIIQELDSGTE XP_004869232.1/1-1041 KDPVQENVPEI--APGSEPESAAPTSEAEHSPDLLVIGPAGEDFISQYDQIIRELDAGSE ENSP00000421580/1-1040 KEPKQEREPEA--APESNSELASPAPEAEHSSNLTAAHPESEELIAQYDQIIKELDSGAE * * . : : :.* ::::.:: * ENSCPOP00000004517/1-887 ----SQFTVPIEPQWPQKDKNS-----------------------------VEKIAEETH ENSMUSP00000113235/1-1081 GLTEQSIPISEPSLLTQQEERR-EECK--------------EEEDDDFDSLMAATPAVEA ENSRNOP00000064685/1-663 GLTEQSVPASEPSLLTHADEGR-TECKAEE-----------EEEDDDFDSLMADTPAEEA XP_004869232.1/1-1041 RLMDQSFLTPQPLLLPREEEGREEECRGEKDGVEEPQQKDVEAEEDDFDSLTAEAPAVAS ENSP00000421580/1-1040 GLMEQNYPTPDPLLLTKEEEGK-EESKGEK---EKEGKKELEDEEDDFDSFIAEMPAVET .. . .: :: . ENSCPOP00000004517/1-887 GPAPSALK----------PLILP----TGPFISVVLSKLENMLENSLHVNLLLIGILTQL ENSMUSP00000113235/1-1081 GSSPFGVGEDTA-FSSRHPVRTQSTPFTGPFISVVLSKLENMLENSLHVNLLLIGIITQL ENSRNOP00000064685/1-663 APSPFGVGEDTATFTSRHPTRTQGTPFTGKFMSVVKS----------------------- XP_004869232.1/1-1041 VPSPWGAREEAA-FAGHHPVRTPSTPFTGPFMSVVLSKLENMLENSLHVNLLLIGIITQL ENSP00000421580/1-1040 VPSPFVGRDEAA-FASRHPVRTQSTPFTGPFISVVLSKLENMLENSLHVNLLLIGIITQL .:* * ** *:*** * ENSCPOP00000004517/1-887 ASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPSLLIQAQQYLLF ENSMUSP00000113235/1-1081 ASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQYLLF ENSRNOP00000064685/1-663 ------------------------------------------------------------ XP_004869232.1/1-1041 ASYPQPLLRSFLLNTNMVFQPSMRSLYQVLASVKNKIEHFASMERDFPGLLIQAQQYLLF ENSP00000421580/1-1040 ASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQYLLF ENSCPOP00000004517/1-887 RVDTSEVTPVALTPGRGRRFPAAFPSARRELWELSSKMIFKAVKCRQADPIPEASKTGSG ENSMUSP00000113235/1-1081 RVDMSDMAPAALTK----------------------------------DPIQEISRPESD ENSRNOP00000064685/1-663 ------------------------------------------------------------ XP_004869232.1/1-1041 RVDMSDVTPEALTK----------------------------------DPIQEASKTGSS ENSP00000421580/1-1040 RVDMSDMTPAALTK----------------------------------DPIQEASRTGSG ENSCPOP00000004517/1-887 RNLLDGPPRVLQPFLTNRAKVAGAPPNLPLPVRNTMLAAALFPEFLKELAALAQEHSI-- ENSMUSP00000113235/1-1081 KTLLDGPPRVLQPFLGNRAKVTRAPPNLPLPVKNTMLAAALFPEFLKELAALAQEHSILC ENSRNOP00000064685/1-663 ------------------------------------------------------------ XP_004869232.1/1-1041 RNLLDGPPRVLQPFLTSRARVAGPPPNLPLPVRNTMLAAALFPEFLKELAALAQEHSILC ENSP00000421580/1-1040 KNLLDGPPRVLQPFLTHRTKVAEAPPNLPLPVRNPMLAAALFPEFLKELAALAQEHSILC ENSCPOP00000004517/1-887 ------------ ENSMUSP00000113235/1-1081 YKILGDFEDSCC ENSRNOP00000064685/1-663 ------------ XP_004869232.1/1-1041 YKILGDFEDSCC ENSP00000421580/1-1040 YKILGDFEDSCC