CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000108675/1-1455 MAGPGSWRDKEVTDLGQLPDPTGIFSLDKAIGLGTYGRIFLGIHEKTGSLVAVKVMSARK ENSRNOP00000053882/1-1454 MAGPGSWRDKEVTDLGHLPDPTGIFSLEKTIGLGTYGRIYLGLHEKTGSFVAIKVMNARK ENSCPOP00000004423/1-1239 ------------------------------------------------------------ ENSP00000438378/1-1583 MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK XP_004861532.1/1-1575 MAGPGGWRDKEIADLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK ENSMUSP00000108675/1-1455 TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGAFFKLNPPG ENSRNOP00000053882/1-1454 TPLPEIGKRVRVNKYRKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGAFFKLNPPG ENSCPOP00000004423/1-1239 ------------------------DEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG ENSP00000438378/1-1583 TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG XP_004861532.1/1-1575 TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG ***********************:********.*** ENSMUSP00000108675/1-1455 HQHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHQVIHRDIKG ENSRNOP00000053882/1-1454 HQHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHQVIHRDIKG ENSCPOP00000004423/1-1239 HRHQLWIVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG ENSP00000438378/1-1583 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG XP_004861532.1/1-1575 HRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG ::****:***************** **************************:******** ENSMUSP00000108675/1-1455 QNVLLTHDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRCSYDYRSDV ENSRNOP00000053882/1-1454 QNVLLTQDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRRSYDYRVT- ENSCPOP00000004423/1-1239 QNVLLTHNAEVKLVDFGVSAQVSRANGRRNSFIGTPYWMAPEVINCDEDPRHSYDYRSDV ENSP00000438378/1-1583 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV XP_004861532.1/1-1575 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRRSYDYRSDV ******::****:***********:*******************.****** ***** ENSMUSP00000108675/1-1455 WSVGITAIEMAEGAPPLCKLQPLEALCVILREAAPKVKSSGWSRKFQNFMENCMIKNFLF ENSRNOP00000053882/1-1454 ----------------LCNLQPLEALFVILREAAPTVKSSGWSRKFQNFMENCMIKNFLF ENSCPOP00000004423/1-1239 WSVGITAIEMAEGVPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCMIKNFLF ENSP00000438378/1-1583 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF XP_004861532.1/1-1575 WSVGITAIEMAEGAPPLCNLQPLEALFIILRESAPTVKSGGWSRKFHNFMEKCMIKNFLF **:******* :****:**.***.******:****:* ****** ENSMUSP00000108675/1-1455 RPTSGNMLLHPFVHDIKNERRVVESLTKHLTGIIQKRE-KKGIPVAFEGEEAAKEQYITR ENSRNOP00000053882/1-1454 RPTSGNMLHHPFVHDIKNERRVVESLTKHLTGIIQKRE-RKGIPLAFEGEEAVNEQYITR ENSCPOP00000004423/1-1239 RPTSANMLHHPFVQDIKNEQHVIESLTKHLTGIIKKRQ-KKDESRIYSFIDFKQE---AE ENSP00000438378/1-1583 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKKGIPLIFEREEAIKEQYTVR XP_004861532.1/1-1575 RPTSANMLVHPFVQDIKNEQHVVESLTKHLTGIIKKRQ-KKGIPLVFEREEVIKEQYTMR ****.*** ****:*****::*:****:******:**: :*. . :. : :* . ENSMUSP00000108675/1-1455 RFRWPSCTPELLRVPTSSRCRPLRVLHGEPPQPRWLPDQEDPQDQELQQLQKAAGVFMPL ENSRNOP00000053882/1-1454 RFRGPSCTPELLRVPTSSRCRPLRVLHGEPPQPRWLPDEEQPEDQELQQLQEAARMFMPL ENSCPOP00000004423/1-1239 SHKGPSCTQELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQHLHGAARVFMPL ENSP00000438378/1-1583 RFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPL XP_004861532.1/1-1575 RFRGPSCTHELLRLPTSSQCRPLRVLHGEPSQPRWFPDREDPQVQALQHLQGAARVFIPL .: **** ****:****:***********.****:**.*:*: * **:*: ** :*:** ENSMUSP00000108675/1-1455 HSQDNTSKLFPKQVEVAPYLRGAAQVVMPV------------LVQVEAPPQVSKAAQMLK ENSRNOP00000053882/1-1454 HSQDKTLKPLQKQAQLPQHLHVAPQVLMPV--QVEATVATPLAKKIRAPPQLSKAAWGLT ENSCPOP00000004423/1-1239 QAQDNAQRPLRGQAQASQRLYRAARVFMPLQAQVKAKASRPLHMQIKASPRLRRAARLLM ENSP00000438378/1-1583 QALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLM XP_004861532.1/1-1575 QAQDNAHRPLQRQAQAPQRLHGAARVFMPLQAQVKAKASRPLHMQIKAPLRLRRAARMLM :: *.: : : *.: . * *.:*.**: ::.*. :: :** * ENSMUSP00000108675/1-1455 SLPTQDNKATSPEVQAPVAEGQQAQHEAL--ETEQPKDLDQVPEEFQGQDRAPEQ-PRQG ENSRNOP00000053882/1-1454 SPPSQDNKASSPEVQAPIPREQQAQNDAL--ETEQPEDLDQVPEEFQGQDRAAEE-QRQG ENSCPOP00000004423/1-1239 PLQSQGKILRPLQLQAPLLKMPQPQALSQTQELKQPQDLDHVPEEY-------------- ENSP00000438378/1-1583 PLQAQVRAPRLLQVQSQVSKKQQAQT-----QTSEPQDLDQVPEEFQGQDQVPEQ-QRQG XP_004861532.1/1-1575 PLQSQGKLLRPLQIWASVLKMRQAQAEAQTHELKQPQDLDQVPEEFQGQDQVPEQVQRQG . :* . :: : : . *.* : .:*:***:****: ENSMUSP00000108675/1-1455 QAAEQQQIHNPVPEQPPEEDREPEQAEVQEEAVEPPQAEIEDKEPEVVQVHAQVLLPLLS ENSRNOP00000053882/1-1454 QAAEQEQRQNGVPEQHPEENREPEQAEVQEEAVEPPQAEVEEKDPEVIQVHARVFLPLQS ENSCPOP00000004423/1-1239 -------------------------PEAEEQAAEPAQADAEAEEPEPLRVHAQVFLPLLS ENSP00000438378/1-1583 QAPEQQQRHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLS XP_004861532.1/1-1575 QAAEQQQIQNQVPEQNLGQNQAPEQPEVQEQAAEPAQAESEAEEPESLMVHAQVFLPLLS .*.:*:*.**.**: * ::** : *:*:*:*** * ENSMUSP00000108675/1-1455 QNRHVLLPLHLDRQLLIPVGEQNEEVPRAQAWDLEASRAVGAVQALIEGLSRDLLRAPNA ENSRNOP00000053882/1-1454 QNHHVFLPLHLDTQLLIPVGEQNEEAPRAQAWDLEASRAAGAVQALVEGLSRDLLRAPNA ENSCPOP00000004423/1-1239 QSHHVLLPLHLDTQELIPVGQPTEGSPPSHSWTLEPSEAVNSVQALIDGLSKDLLRAPDA ENSP00000438378/1-1583 QDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNS XP_004861532.1/1-1575 QSHHVLLPLHLDTQVLMPVGGPTEGSPQAHAWTLEPSQAVSSVQALIDGLSTYLLRAPNS *.:**:****** * *:** .* * :::* **...* .:****::*** *****:: ENSMUSP00000108675/1-1455 FVTKPLGPLQIFLENLSTDGFYTEPEPTQKKKSKVASLRKAIAKRLRPKRFRAKALWRLE ENSRNOP00000053882/1-1454 FTSKPLGPLQILLESLCTNGFYTEPEAVQKKKSRVSSLKKAIVKRLTPKRFRAKALWRRQ ENSCPOP00000004423/1-1239 HNSKPLGLLQTLMENLSSNVFYSQPEQ--------PALRQALAKRLSPKNFRSPEAQTPT ENSP00000438378/1-1583 NNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPE XP_004861532.1/1-1575 HNSKPLGLLQTLMENLSSDVFYSQPEQSGKKKSKVSSLRQALAKRLSPKRFRAKSS--PE :**** ** ::*.*.:: **::** .:*::*:.*** **.**: ENSMUSP00000108675/1-1455 DFEFSDVETSRRRRHRRWEDIFNQHEEQLRRVENDR-EDDSSDNDEVFHSIQAEVQIE-- ENSRNOP00000053882/1-1454 DFECSDVESSRRRRQRRWEEIFNQHEEQLREVENDRDDDDSSDNDEVFHSIQAEVQIE-- ENSCPOP00000004423/1-1239 QL--------------------TQYSDSIGTLIHSS-SHHSSRS---------------- ENSP00000438378/1-1583 KLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDK-EDESSDNDEVFHSIQAEVQIEPL XP_004861532.1/1-1575 EIEHSYLEARRHRRRRRLEGVFNEHEEDLSQFENDK-DEGSSDNDEVFHPIQAEVQIEQL .: .::.:.: . :. .. ** . ENSMUSP00000108675/1-1455 -PHAANPAGNEVHERSAPMPCNRNRTHRVKFSPSVGEEEPSLEEAQPQQQQQQPMNIRPR ENSRNOP00000053882/1-1454 -PYAPNRTGNEVQERSAPMPCNRNRTHRVKFSPSVC-EQALLEEA------QQPMDIRPR ENSCPOP00000004423/1-1239 -------------------PNGTSAATHSKSSRNLY-LQFGLE----------------R ENSP00000438378/1-1583 KPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVP-QRSLLEQA------QKPIDIRQR XP_004861532.1/1-1575 QPYIPNPTENEIQDRSISMPYNQDCTHRVKFFSSDP-QRSPLEQA------QKPIDIRQR * . . : : * . . ** * ENSMUSP00000108675/1-1455 NCLNPQNFQAQSDSSSEEDSPVTRRKSQSSPPYSTIDQKLLIDIHVPDGFKVGKISPPVY ENSRNOP00000053882/1-1454 NSLNPRNFQAESESSSEEDSPVTRRKSQSSPPYSTIDQRLLIDIHVPDGFKVGKISPPVY ENSCPOP00000004423/1-1239 SSQNPQNFQAASGSILGKTNKKYLRK--TTPIY--------------------------Y ENSP00000438378/1-1583 SSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY XP_004861532.1/1-1575 SSQNPQNFQAASESS-EEESPVTGRRSQSSPPYCTIDQKLLVDIHVPNGFKVGKISPPVY .. * :*: * * * : . *: ::* * * ENSMUSP00000108675/1-1455 LTNEWVGYNALSEIFWDDWIMPTRPARPPEEDGDYVELYDADANANGDE----EVANGAY ENSRNOP00000053882/1-1454 LTNEWVGCNPLSEVFWDDWVNPTPATRRHEEDGDYVELYDADANGDGRA------SNYAY ENSCPOP00000004423/1-1239 L--------------------PDSLIKK-------LHLYLFSANILKRE----------- ENSP00000438378/1-1583 LTNEWVGYNALSEIFRNDWLTPAPVIQPPEEDGDYVELYDASADTDGDD---DDESNDTF XP_004861532.1/1-1575 LTNEWPGNNSLSEVFWNEWLTPTPVIQPPEEDGDYVELYDAGADTDGNDGVANGASSGAC * * : :.** .*: ENSMUSP00000108675/1-1455 EDPRDGANGHDDMNNQLDQANG-YEGHGAAGYNGG---DVGGNHGAAFNGPRANYPRAGI ENSRNOP00000053882/1-1454 EENY--ASGHDDMNH---QANG-YRGHGNRHYSDGSFRNRGDSRGAAFNGPRASYCRGGI ENSCPOP00000004423/1-1239 -------------------ENNVCEDHDVGDSIDKSVDDIDNSHDDANRSRRT---QDAL ENSP00000438378/1-1583 EDTYDHANGNDDLDNQVDQANDVCKDHD--DDNNKFVDDVNNNYYEAPSCPRASYGRDGS XP_004861532.1/1-1575 EDTYDHSNGNDDLDNQVAQENDVCEDHGVVDNIDVSVDGIDNNPVYAPNCSRASCVKDGS *. ..*. . . ... * *: : . ENSMUSP00000108675/1-1455 LKNGHNDGRALNRGAFGVFGDNAARAFHG--AAGEAGAAFGN---HGANRGNG-RG---N ENSRNOP00000053882/1-1454 LKNAGNDGRDLRRGAFRAYGDNEASNYHG--AASGASAAFGSQEGHEGHMGGR-RG---N ENSCPOP00000004423/1-1239 IAKMH------------ALTPGFNSQYHTS-KERASCDKHGSSQQDGSESGAE-RDIRSN ENSP00000438378/1-1583 CKQDGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGD XP_004861532.1/1-1575 CKQDGSDEKE-------DTSRGNSSRSHGS-TASGGSEAIGYQERHGGDIGSE-RGSGSN : * * . .. * *. : ENSMUSP00000108675/1-1455 RNREANGRNEENGAFGR--------------D-QHVFPEFEH--EESDRGTETSDSIALE ENSRNOP00000053882/1-1454 RYREVNGSSGENGACGF-------HRDGAGLDQQHVFPDFENEQEQSDAGTETSDSIALE ENSCPOP00000004423/1-1239 GNNINVN--------------------------TKIVVSF----QELNGGSEDSTSIVSD ENSP00000438378/1-1583 GGKGVVRTSEESGALGLNGEENCSETDGPGLK-RPASQDFEYLQEEPGGGNEASNAIDSG XP_004861532.1/1-1575 GNKGVSGNNEESRACGFNGGEKQSDTDGPGLK-RPIFHDFEPQPEELNSGSEGSNSIASH . .* :: . *.* * :* ENSMUSP00000108675/1-1455 ITSFD---GEQNSGRPVSSTTMGFPIGRSSP-RGSDFGSDI------------------- ENSRNOP00000053882/1-1454 ITSFSLD-GEQNNDRAEPT--LGFPLRRSSS-RGSASDTDI------------------- ENSCPOP00000004423/1-1239 VPSPELDDVDGSTGTSESSTQLDFFANNSSPSKGSGMAANADLACAIYRLSFVLSDGLVI ENSP00000438378/1-1583 AAPSAPDHESDNKDISESSTQSDFSANHSSPSKGSGMSADANFASAI------------- XP_004861532.1/1-1575 AALPELDDGDGDIDTSESSIQSDFFENNSSPSKGSGMAANADFACAI------------- . . . . . .: .* .**. :** :: ENSMUSP00000108675/1-1455 ---------------------------------------SYNSPILHVYEKDFSSEVYCG ENSRNOP00000053882/1-1454 ------------------------------------MSDSYNKPIIHAYEREFSHEIFCG ENSCPOP00000004423/1-1239 FKMIPAAVTVSLYSGFMEVPEKSTKRTFEVNVNPTCVSSACKKPLIHMYEKEFTSEIYCG ENSP00000438378/1-1583 -----------LYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCG XP_004861532.1/1-1575 -----------LYAGFMEVPEKSTERNFEVNVNPPFVSSTCKKPLIHMYEKEFTSEIYCG : :.*::* **::*: *: ** ENSMUSP00000108675/1-1455 SLWGVNLLLGTQSHLYLMDRSGKAEIVKLIKRRPFRQIQVVEQLNLLITISGKKNRLRVY ENSRNOP00000053882/1-1454 SLWGVNLLLGTKSHLYLMDRSGKAEIIKLVKRRPFRQIQVVEQLNLLITISGRKNRLRVY ENSCPOP00000004423/1-1239 SLWGVNLLLGTRSNLCLLDRSGEANITKLIKRRPFRQIQVVESLNLLITISGHKNRLRVY ENSP00000438378/1-1583 SLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVY XP_004861532.1/1-1575 SLWGVNLLLGTGSNLCLLDRSGKANITKLIKRRPFRQIQVVEPLNLLITISGHKNRLRVY *********** *:* *:****:*:* **::*********:* *********:******* ENSMUSP00000108675/1-1455 HLSWLRNKILNNDPKSKKRQKAMRKKEEACKAIDKLIGCEHFSVLQHEETTYIAVAVKSS ENSRNOP00000053882/1-1454 HLTWLRNKILNNDPESKKRQKAMLKREKACKSLDKLIGCEHFSILHHEETTYIAIALKSS ENSCPOP00000004423/1-1239 HLTWLRNKILNNDPESKKRQQEMLKTEQTCRAIDKLTGCEHFSVLQHEETTYIAIALKSS ENSP00000438378/1-1583 HLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSS XP_004861532.1/1-1575 HLTWLRNKILNNDPESKRRQQEMLKTEEACRAIDKLTGCEHFSVLQHEETTYIAIALKSS **:***********:**:**: * * *::*:::*** ******:*:********:*:*** ENSMUSP00000108675/1-1455 IHLFAWAPKSFDENTAIK------------------------------------------ ENSRNOP00000053882/1-1454 IHLYAWAPKSFNESTAIK------------------------------------------ ENSCPOP00000004423/1-1239 VHLYAWTSESFDESTAIK------------------------------------------ ENSP00000438378/1-1583 IHLYAWAPKSFDESTAIK-VCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDEL XP_004861532.1/1-1575 IHLYAWTSKSFDERTAIKQVCFDQSVGSKGHYMFYEGYIQILAKIQAAD-------PDEL :**:**:.:**:* **** ENSMUSP00000108675/1-1455 -------VFPTRDLKPLTVDLAVGSEKTLKIFFSSANGYHIIDAESEVMSEVTLPN---- ENSRNOP00000053882/1-1454 -------VFPTHDLKPVTVDLAVGSEKTLKIFFSSANGYHIIDAESEVMSDVTLPS---- ENSCPOP00000004423/1-1239 -------VFPTLDHKPVTVDLAIGSEKKLKIFFSTENGYHIIDVESTVISDVSLPPLVHI ENSP00000438378/1-1583 LHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPK--NP XP_004861532.1/1-1575 LHLLNLKIFPTLDHKPVTVDLTMDSERRLKIFFSSENGYHIIDAESEVLSDVILPS--NP :*** * **:****::.**: ******: :***:**.** *:*:* ** ENSMUSP00000108675/1-1455 ------NNVVILPDCLGLGVMLSLNAEAASEEANEQLLKKILDVWKDIPSSVAFECTKRI ENSRNOP00000053882/1-1454 ------NNVILLPDSLGVGVMLSFNDETAPEEANEQLLKKILDVWKDIPSSAAFECTQRI ENSCPOP00000004423/1-1239 YAYLKSHNIIILPDGLGIGMMLTFNAEALSVEANEQLFKNILEVWKDIPSSVAFECTQRT ENSP00000438378/1-1583 LEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRT XP_004861532.1/1-1575 LEIIIPQNIIILPDCLEIGMMLTFNAETLSVEANEQLFKKILEVWKDIPSSVAFECTQRT :*:::*** * :*:**::* *: . ******:*:**::******* *****:* ENSMUSP00000108675/1-1455 TGWDQKAIEVRSLQSTILENELKRRSIKKLRFLCARGDKMFFASTLSNDHSRVYLMSLGK ENSRNOP00000053882/1-1454 TGWDQKAVEVRSLQATILENELKRRSIKKLRFLCSRGDKLFFASLLNNEHSLVYYVSIAK ENSCPOP00000004423/1-1239 TGWSQKAIEVRSLQSSVLESELKARSIKTLRFLCIRGDKLFFTSTLHNRHSRVYFMTLGR ENSP00000438378/1-1583 TGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK XP_004861532.1/1-1575 TGWGQKAIEVRSFQSSVLESELKARSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGR ***.***:****:*: :**.*** ****.***** ****:**:* * * ** ** :::.: ENSMUSP00000108675/1-1455 LEELHRSYAV ENSRNOP00000053882/1-1454 LEALQRRYAV ENSCPOP00000004423/1-1239 LEELRSNY-- ENSP00000438378/1-1583 LEELQSNYDV XP_004861532.1/1-1575 LEELQSSYSV ** *: *