CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000004398/1-1499 --RAVQMAAPGEPCAGPGVWNQSEPEPAVNHLLSLCFLRAAGVWLPPLYLWVLGPFYLLY XP_004855843.1/1-1501 ------MAAPGEPCTGPGVWNQTEPEPAASHLLSLCFLKAAGVWVPPLYLWVLGPFYLLY ENSP00000205557/1-1503 ------MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLF ENSMUSP00000002850/1-1498 MNRGRSMATPGEQCAGLRVWNQTEQEPAAYHLLSLCFVRAASSWVPPMYLWVLGPIYLLY ENSRNOP00000051412/1-1502 MNGEHSMATPGESCAGLRVWNQTEQEPVAYHLLNLCFLRAAGSWVPPMYLWVLGPIYLLY **:*.* *:* ****:* **.. **.***:::*. *:**:*******:***: ENSCPOP00000004398/1-1499 IHHHGQGYLRMSPLFKAKMVLGLALILLCTFNVAVPLWRIQQGQSQTPEVLIHPTVWLTT XP_004855843.1/1-1501 IHRHGRGYLRMSPLFKAKMVLGFALILLCTFNVAVPLWRIQQGKPQAPEVLIRPAVWLTT ENSP00000205557/1-1503 IHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTT ENSMUSP00000002850/1-1498 IHRHGRCYLRMSHLFKTKMVLGLALILLYTFNVAVPLWRIHQGVPQAPELLIHPTVWLTT ENSRNOP00000051412/1-1502 IHRHGCCYLRMSRLFKIKMVLGFALILLYTFNAAVPLWRIHRGMPQAPELLIHPTVWLTT **:** ***** *** *****:***:* * ..**.**:*::* .::**.**:*:***** ENSCPOP00000004398/1-1499 MSFAMFLVHVERKKGVRASGVLFGYWLLCCLLPAISAVQQASSGDFQSDPLHHLSTYLCL XP_004855843.1/1-1501 MTFAMFLVHVERKKGVQASGVQFGYWLLCCLLPATSTAQQASSGDFLSDPLRHLSTYLCL ENSP00000205557/1-1503 MSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCL ENSMUSP00000002850/1-1498 MSFATFLIHMERRKGVRSSGVLFGYWLLCCILPGINTVQQASAGNFRQEPLHHLATYLCL ENSRNOP00000051412/1-1502 MSFATFLIHMERKKGVRASGLLFGYWLLCCLVPAIDTVQQASAGSFRQEPLHHLATYLCL *:** **:* **:***::**: ******* ::*. .:.****...* .:*::**:***** ENSCPOP00000004398/1-1499 SLVMAEFVLSCLVDQPPFFQNGPQQSNPCPEAGASFPSKVLFWWASRLLWKGYRKSLRPE XP_004855843.1/1-1501 SLVMAEFVLSCLVDQPPFFQKDSQQANPCPEAGVSFPSRAAFWWASGLLWRGYRKPLRPK ENSP00000205557/1-1503 SLVVAQFVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPK ENSMUSP00000002850/1-1498 SLVVAELVLSCLVDQPPFFSEDSQPLNPCPEAEASFPSKAMFWWASGLLWRGYKKLLGPK ENSRNOP00000051412/1-1502 SLVVAELVLSCLVDQPPFFSEDSKPLNPCPEAEASFPSKAMFWWASGLLWKGYRKLLGPK ***:*::*****.****** :..: *****: .:***:. ***.* *:*:**:: * *: ENSCPOP00000004398/1-1499 ELWNLERENTSEELVSQLEREWLRNHGVAQGCT---MGLKGSEHENQAGQELEALLPQRR XP_004855843.1/1-1501 DLWSLEPENSTEELVSQLEREWMRNRGVAQGCATAELKGPNRGSGSRAAPELQALVPRGG ENSP00000205557/1-1503 DLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKA-IAFKRKGGSGMKAPETEPFLRQEG ENSMUSP00000002850/1-1498 DLWSLGRENSSEELVSQLEREWRRSCNGLPGH---------KGHSSVGAPETEAFLQPER ENSRNOP00000051412/1-1502 DLWSLERENSSEELVSQLEREWRRNFSELPGH---------KGHSGMGTPETEAFLQPER :**.* **::*****:**:** *. . . * :.:: ENSCPOP00000004398/1-1499 HPRGPLLGAIWRVFRCSFLLGTLSLIIADAFRFAVPKLLSLFLEFMGDLQAPAWQGSLLA XP_004855843.1/1-1501 RPRGPLLRALWSVFCGSFLLGTLSLLVADAFRFAVPKLLSLFLEFMGTPQSPAWQGSLLA ENSP00000205557/1-1503 SQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLA ENSMUSP00000002850/1-1498 SQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFMGDRNSSAWTGWLLA ENSRNOP00000051412/1-1502 SQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFMGDLESSAWTGWLLA *** *:* ** :********:::*.***:***********:* :..** * *** ENSCPOP00000004398/1-1499 LLLLLSAGLQTLFEQQHMYRLKLLQMRLRSALIGLVYRKVLVLSPGAHKSSAVGDVVNLL XP_004855843.1/1-1501 VLMLLSAGLQTLFEQQHMYRLKALQMRLRTALAGLVCRKVLVLSRGAKKAGAVGDVVNLL ENSP00000205557/1-1503 VLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLV ENSMUSP00000002850/1-1498 VLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLV ENSRNOP00000051412/1-1502 VLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLV :*:: :* ******** *** * ******:*: *** ****.** *::*:.*.******: ENSCPOP00000004398/1-1499 SVDVQRLSESVLYLNGLWLPLLWMVVCFAYLWQLLGPSAFTAIAVFLGLLPLNFFISKKK XP_004855843.1/1-1501 SVDVQRLSESVLYLNGLWLPLLWITVCFVYLWQLLGPSALTAVAVFLGLLPLNFFISKKR ENSP00000205557/1-1503 SVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKR ENSMUSP00000002850/1-1498 SVDIQRLAESIIYLNGLWLLFLWIFVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKR ENSRNOP00000051412/1-1502 SVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKR ***:*** **:::****** ::*: ***.**********:**:****.********:**: ENSCPOP00000004398/1-1499 THHQEEQMRQKDSRARLTGFILRTMRTIKSHGWEEAFLERVLHIRGRELGALRTSTLLFS XP_004855843.1/1-1501 SHHQEGQMRRKDSRARLTSAVLRAMRTVKSQGWEAAFLDRVLRIRGRELGALRTSSLLFS ENSP00000205557/1-1503 NHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFS ENSMUSP00000002850/1-1498 GFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQELSALKTSTLLFS ENSRNOP00000051412/1-1502 SFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQELGALKTSAFLFS .*** ***:* ******. :** :*:* :*** ***:*:* ***:**.**:** :*** ENSCPOP00000004398/1-1499 VSLVSFQVSTFLVALVVFAVHTLVAEENAMDAEKAFVTLTVLGILNKAQAFLPFSIHCVV XP_004855843.1/1-1501 VSLVSFQVSTSLAALVVFAVHTLVAEENAMDAEKAFVTLAVLGILNKAQAFLPFCAHCLV ENSP00000205557/1-1503 VSLVSFQVSTFLVALVVFAVHTLVAE-NAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLV ENSMUSP00000002850/1-1498 VSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCIV ENSRNOP00000051412/1-1502 VSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCLV ********** *.************* ***:********:**.***********. *.:* ENSCPOP00000004398/1-1499 QARVSFDRLAAFLYLEEVDPGAVVLSPSRCPPGKDCITIQDGTFTWSRESPPCLHRINLT XP_004855843.1/1-1501 QARVSFDRLAAFLYLEEVDPGAVDSSPSRGSPGKDCIAIRDGTFAWSQESPPCLHRINLT ENSP00000205557/1-1503 QARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLT ENSMUSP00000002850/1-1498 QARVSFDRLAAFLCLEEVDPNGMIASNSRRSS-KDRISVHNGTFAWSQESPPCLHGINLT ENSRNOP00000051412/1-1502 QARVSFDRLAAFLCLEEVDPNGMVLSPSRCSS-KDRISIHNGTFAWSQESPPCLHGINLT *********.:** ******. : * * .. ** *:::..**:**:******* **** ENSCPOP00000004398/1-1499 VPQGCLLAIVGPVGAGKSSLLSALLGELSKLEGSVSMQGSVAYVPQEAWVQNTSVVENVC XP_004855843.1/1-1501 VPQGCLLAIVGPVGTGKSSLLSALLGELSKLEGSVSIQGPVAYVPQEAWVQNTSVVENVC ENSP00000205557/1-1503 VPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVC ENSMUSP00000002850/1-1498 VPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVC ENSRNOP00000051412/1-1502 VPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVC ********:*****:************* *:** **::*.******************** ENSCPOP00000004398/1-1499 FQQELNLPWLETVLQACALGPDVESFPAGMHTPTGEQGMNLSGGQKQRLSLARAVYRKAA XP_004855843.1/1-1501 FRQELDLSWLERVLEACALGPDVDSFPAGIHTLIGEQGMSLSGGQKQRLSLARAVYRKAA ENSP00000205557/1-1503 FGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAA ENSMUSP00000002850/1-1498 FRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLSLARAVYKKAA ENSRNOP00000051412/1-1502 FRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQKQRLSLARAVYRRAA * ***: .**: **:**** .** *** *:** *****.****************::** ENSCPOP00000004398/1-1499 VYLLDDPLAALDAHVGQHVFHQVIGPRGLLQGTTRILVTHALHVLPHVDQVMVLEDGGIT XP_004855843.1/1-1501 VYLLDDPLAALDAHVGQHVFNQVIGPSGLLQGTTRILVTHALHVLPQADRIAVLADGCIT ENSP00000205557/1-1503 VYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIA ENSMUSP00000002850/1-1498 IYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVTHTLHVLPQADRILVLANGTIA ENSRNOP00000051412/1-1502 VYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLHVLPQADQILVLANGTIA :**:***********.*.**:***** *************:**:**:.* : ** :* *: ENSCPOP00000004398/1-1499 EMGSYQELLHRKGALVALLEAARQPGE-----TEPAANTSDP----GGGGPEHRPESPAY XP_004855843.1/1-1501 EVGSYQELLRRKGALVALLEGARQSGGGGDREAQPAASTSDP----GGRRPDHR--SERS ENSP00000205557/1-1503 EMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELR--RERS ENSMUSP00000002850/1-1498 EMGSYQDLLQRNGALVGLLDGARQPAG-----THDAATSDDLGGFPGGGRPTCRPDRPRP ENSRNOP00000051412/1-1502 EMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAHAAATSDDLGGFSGGGTPTRRPERPRP *:****:**:*:***: **: ***.. :. .:.:.* .* * * ENSCPOP00000004398/1-1499 LSRLPSKKRAASQQQQQNRISWCFQKFPLQLDRELQSGRVKAAMYLSYLQAVGIPLCTYT XP_004855843.1/1-1501 IKPTPTRGGGISEAQAAAALDGPRGTGQPGGEGSVQYGRVKAAMYLSYLQAVGIPLCTYT ENSP00000205557/1-1503 IKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYA ENSMUSP00000002850/1-1498 TEAAPVKGRSTSEVQMEASLDDPEATGLTAEEDSVRYGRVKTTIYLSYLRAVGTPLCTYT ENSRNOP00000051412/1-1502 SDAAPVKG-STSEAQMEPSLDDVEVTGLTAGEDSVQYGRVKSATYLSYLRAVGTPLCTYT . * : *: * :. . .:: ****:: :*:**:*** *** *: ENSCPOP00000004398/1-1499 LFLFLCQQVASFCRGYWLSLWADDPVVDGQQMQTALRGWVFGLLGCLQAVGLFASMAAVF XP_004855843.1/1-1501 LFLFLCQQVASFCRGYWLSLWADDPVVDGQQMQTALRGWVFGLLGCLQAIGLFASMAAVF ENSP00000205557/1-1503 LFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVL ENSMUSP00000002850/1-1498 LFLFLCQQVASFSQGYWLSLWADDPVVDGRQMHAALRGWVFGLLGCLQAIGLFASMAAVF ENSRNOP00000051412/1-1502 LFLFLCQQVASFCQGYWLSLWADDPVVDGKQMHSALRGSIFGLLGCLQAIGLFASMAAVF ************.:***********.*.*:* ::**** :*********:*********: ENSCPOP00000004398/1-1499 IGGVQASSLLFRRLLWDVARSPIGFFERTPVGKLLNYFSKEMDMVDVEIPDKLQALLTYT XP_004855843.1/1-1501 LGGVQASSLLFQRLLRDVARSPIGFFERTPVGNLLNHFSKEMDTVDVEIPDKLQALLTYT ENSP00000205557/1-1503 LGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYA ENSMUSP00000002850/1-1498 LGGARASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYA ENSRNOP00000051412/1-1502 LGGARASCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDIVDVDIPDKMRTLLTYA :**.:** ***: ** **.****.******:*:*** **** * ***:****:::** *: ENSCPOP00000004398/1-1499 FGLLEVCLAVTMVTPLAIVAILPLMLLYARFQSLYVATSCQLRRMESASYSSVCSHVAET XP_004855843.1/1-1501 FGLLEVCLAVMTATPLAIVAILPLMLLYAGFQSLYVATLCQLRRIESASYSSVCSHVAEM ENSP00000205557/1-1503 FGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAET ENSMUSP00000002850/1-1498 FGLLEVGLAVTMATPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAET ENSRNOP00000051412/1-1502 FGLLEVGLAVSMATPLAIVAILPLMLLYAGFQSLYVATCCQLRRLESASYSSVCSHLAET ****** *.* .**** ******::*** ******.: *****:*** *******:** ENSCPOP00000004398/1-1499 FQGSAVVRAFQAQGHFVAQSDALMDANQRVSFPRLVADRWLATNLELLGNGLVFVAAMCA XP_004855843.1/1-1501 FQGSAVVRAFQAQDHFVAQSDALMDMNQRVSFPRLVADRWLAVNLELLGNGLVFVAAMCA ENSP00000205557/1-1503 FQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCA ENSMUSP00000002850/1-1498 FQGSLVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCA ENSRNOP00000051412/1-1502 FQGSQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRWLAANLELLGNGLVFVAATCA **** *****::* *.** :* :* .**:***:********.*:*********.** ** ENSCPOP00000004398/1-1499 VLSKDHLRAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVSVERVQDYTHTPKEAPWML XP_004855843.1/1-1501 VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMLSVERVQDYAHTPKEAPWTL ENSP00000205557/1-1503 VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRL ENSMUSP00000002850/1-1498 VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRL ENSRNOP00000051412/1-1502 VLSKAHLSAGLAGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYVHTPKEAPWRL **** ** ***.*******************.*******:::***:***. ****** * ENSCPOP00000004398/1-1499 PTCAAQPPWPHGGQIEFRDFGLRHWPELPLAVRGVSFKVQAGEKVGIVGRTGAGKSSLAG XP_004855843.1/1-1501 PACAARPPWPRGGQIEFRDFGLRHWPELPLAVRGVSFQVHAGEKVGIVGRTGAGKSSLAG ENSP00000205557/1-1503 PTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLAS ENSMUSP00000002850/1-1498 PTCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSSLAW ENSRNOP00000051412/1-1502 PSSAAQPLWPCGGQIEFRDFGLRHRPELPMAVQGVSLKIHAGEKVGIVGRTGAGKSSLTW *:.**:* ** ************: ****:**:***::::******************: ENSCPOP00000004398/1-1499 GLLRLQEAAEGGIWIDGVPIAQVGLHTLRSRITIIPQDPILVPGSLRMNLDLRQEHSDEA XP_004855843.1/1-1501 GLLRLQEAAEGGVWIDGVPITQVGLHMLRSRITIIPQDPVLIPGSLRMNLDLLQEHSDDA ENSP00000205557/1-1503 GLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEA ENSMUSP00000002850/1-1498 GLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEG ENSRNOP00000051412/1-1502 GLLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQENTDEG ********:**.:*******:.:*** *****:******:*.********** **::*:. ENSCPOP00000004398/1-1499 LWAALETVQLKAFVASLPGQLLYECAESGDDLSVGQKQLLCLARALLRKTQILILDEATA XP_004855843.1/1-1501 IWAALETVQLKAFVASLPGQLQHECAEHGENLSVGQKQLLCLARALLRNTQILILDEAMA ENSP00000205557/1-1503 IWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATA ENSMUSP00000002850/1-1498 IWAALETVQLKAFVTSLPGQLQYECAGQGDDLSVGQKQLLCLARALLRKTQILILDEATA ENSRNOP00000051412/1-1502 IWAALETVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILDEATA :***********:*:****** ::*: *::*****************:********* * ENSCPOP00000004398/1-1499 AVDLGTELQMQEALGHWFARCTVLLIAHRLRSVMDCARVLVMDNGQVVESGSPAQLLAQE XP_004855843.1/1-1501 AVDPGTELQMQAALGHWFARCTVLLIAHRLRSVMGCGRVLVMDNGQVVESGSPAQLLGQQ ENSP00000205557/1-1503 AVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK ENSMUSP00000002850/1-1498 SVDPGTEMQMQAALERWFTQCTVLLIAHRLRSVMDCARVLVMDEGQVAESGSPAQLLAQK ENSRNOP00000051412/1-1502 SVDPGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLLAQK :** ***:*** * **::**************.*.******:***.*********.*: ENSCPOP00000004398/1-1499 GLFYRLAQESGLV XP_004855843.1/1-1501 GLFYRLAQESGLV ENSP00000205557/1-1503 GLFYRLAQESGLV ENSMUSP00000002850/1-1498 GLFYRLAHESGLA ENSRNOP00000051412/1-1502 GLFYRLAQESGLA *******:****.