CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000071623/1-1474 MGDTAKPYFVKRTKDRGIIDDDDFRRGHPQQDYLIMDDYAKGHSSKMEKGLPKKKISPGN ENSRNOP00000022373/1-1485 MGDTAKPYFVKRTKDRGIIDDDDFRRGHPQQDYLMMDDYAKGHSSKMEKGLPKKKMSPGN ENSP00000365130/1-1495 MGDTAKPYFVKRTKDRGTMDDDDFRRGHPQQDYLIIDDHAKGHGSKMEKGLQKKKITPGN ENSCPOP00000002278/1-1465 MGDTAKPYVVKGTKGRGTVDDDDFRRGHLQQDYLIMDDYAKGHSSKMEKGL----ITPGN XP_004862523.1/1-1503 MGDAVKPYIVKGTKGRGTVDDDDFRRGYLQQDYLIMDDYVKGHSSKMEKGLPKKKITPGN ***:.***.** **.** :********: *****::**:.***.******* ::*** ENSMUSP00000071623/1-1474 YGNTPRKGLYGVSSNPYAFKNPIYSQPAWMNDNHKDQNKKWLSDELAGNADSWREFKPGP ENSRNOP00000022373/1-1485 YGNTPRKGLYAVSSNPYAFKNPMYSQPAWMNDNHKDQNKKWLSDELAGNADSWREFKPGP ENSP00000365130/1-1495 YGNTPRKGPCAVSSNPYAFKNPIYSQPAWMNDSHKDQSKRWLSDEHTGNSDNWREFKPGP ENSCPOP00000002278/1-1465 YGGTARKGPYPASNNPYAFKNPIYSQPVWMNDSHKDQSKRWQTDELAGNLDNWREFKPGP XP_004862523.1/1-1503 YGNTPRKGPYPVSSNPYAFKNPIYSQPVRMNDSHKDQCKRWLFDEVTGNSDNWREFKPGP **.*.*** .*.********:****. ***.**** *:* ** :** *.******** ENSMUSP00000071623/1-1474 RIPVISRSRKESFQESDDAYRWQEGRGCRAVRRLFQKDLSSLEAMSEMEAGSPE-NKKQR ENSRNOP00000022373/1-1485 RIPVLSRSRKESFQESEDTYRWPEGRGCRAVRRLFQKDLASLEAMTEVEAGSPE-NKKQR ENSP00000365130/1-1495 RIPVINRQRKDSFQENEDGYRWQDTRGCRTVRRLFHKDLTSLETTSEMEAGSPE-NKKQR ENSCPOP00000002278/1-1465 RIPVASRPRKDSFQESEESYRWQDGRGCRTVRCLFHKDLTSLETMSELEAGSSENNRKQR XP_004862523.1/1-1503 RIPVTSRPRKDSFQESEDGYRWQDGRGCRTVRRLFPKDLTSLETMSELEAGSPE-NKKQR **** .* **:****.:: *** : ****:** ** ***:***: :*:****.* *:*** ENSMUSP00000071623/1-1474 SRPRKPRRTRTEDSEQDGDLDGPVIDESVLSTKELLGLQQAEERLKRDCIDRLKRRPRNC ENSRNOP00000022373/1-1485 SRPRKPRRTRTEDIEQDGELEGPVIDESVLSTKELLGLQQAEERLKRDCIERLKRRSRNC ENSP00000365130/1-1495 SRPRKPRKTRNEENEQDGDLEGPVIDESVLSTKELLGLQQAEERLKRDCIDRLKRRPRNY ENSCPOP00000002278/1-1465 SRPRKPRRTRNEECEQDGELEGPVIDESALSTKELLGLQQAEERLKRDFIDRLKRKPRNC XP_004862523.1/1-1503 SRPRKPRRTRNEKYEQDGELDGPVIDESVLSTKELLGLQQAEERLKRDFIDRLKRRPRNC *******:**.*. ****:*:*******.******************* *:****:.** ENSMUSP00000071623/1-1474 PTAKYTCKLCDALIDSIPFAHKHIKEKRHKKNLKEKQEEELLTTLPPPAPSQIHAVGSAI ENSRNOP00000022373/1-1485 PTAKYTCKLCDALIDSIPFAHKHIKEKRHKKNLKEKQEEELLTTLPPPAPSQIHAVGSAI ENSP00000365130/1-1495 PTAKYTCRLCDVLIESIAFAHKHIKEKRHKKNIKEKQEEELLTTLPPPTPSQINAVGIAI ENSCPOP00000002278/1-1465 PTAKYTCRLCDVLIESVALAHKHIKEKRHKKNMKEKQEEELLTTLPPPAPSQVRAVGIAI XP_004862523.1/1-1503 PTAKYTCKLCDVLIESVAFAHKHIKEKRHKKNMKEKQEEELLTTLPLPTPSQINAVGIAI *******:***.**:*:.:*************:************* *:***:.*** ** ENSMUSP00000071623/1-1474 DRVVQEFGLHSENLDQRLEIKRVMESVFRHKLPDCSLRLYGSSCSRLGFRDSDVNIDVQF ENSRNOP00000022373/1-1485 DRVVQEFGLHNENLDQRLEIKCAMENVFQHKLPDCSLRLYGSSCSRLGFRDSDVNIDVQF ENSP00000365130/1-1495 DKVVQEFGLHNENLEQRLEIKRIMENVFQHKLPDCSLRLYGSSCSRLGFKNSDVNIDIQF ENSCPOP00000002278/1-1465 DRVVQEFGLHDKDLEQRLEVKRVVGNALQHKLPDCSLRLYGSSCSRLGFKNSDVNIDIQF XP_004862523.1/1-1503 DKVVQEFGLHNENLEQRLEIKRIMEDVFQHKLRDCSLRLYGSSCSRLGFKNSDVNIDIQF *:********.::*:****:* : ..::*** ****************::******:** ENSMUSP00000071623/1-1474 PAVMSQPDVLLLVQECLKNSDSFIDVDADFHARVPVVVCRDKQSGLLCKVSAGNENAWLT ENSRNOP00000022373/1-1485 PAVMSQPDVLLLVQECLKNSDCFIDVDADFHARVPVVVCRHKQSGLLCKVSAGNENAWLT ENSP00000365130/1-1495 PAIMSQPDVLLLVQECLKNSDSFIDVDADFHARVPVVVCREKQSGLLCKVSAGNENACLT ENSCPOP00000002278/1-1465 PAIMSQPDVLLLVQECLRNSDSFTDVDADFHARVPVVVCREKQSGLLCKVSAGNENACLT XP_004862523.1/1-1503 PAIMSQPDVLLLVQECLKNSDAFTDVDADFHARVPVVVCREKQSGLLCKVSAGNESACLT **:**************:***.* ****************.**************.* ** ENSMUSP00000071623/1-1474 TKHLTALGKLEPRLVPLVIAFRYWAKLCSIDRPEEGGLPPYVFALMAVFFLQQRKEPLLP ENSRNOP00000022373/1-1485 TKHLTALGKLEPRLLPLVIAFRYWAKLCSIDRPEEGGLPPYVFALMAVFFLQQRKEPLLP ENSP00000365130/1-1495 TKHLTALGKLEPKLVPLVIAFRYWAKLCSIDRPEEGGLPPYVFALMAIFFLQQRKEPLLP ENSCPOP00000002278/1-1465 TKHLSILGKLEPRLVPLVIAFRYWAKLCAIDRPEEGGLPPYVFCLMAIFFLQQRKEPLLP XP_004862523.1/1-1503 TKHLSILGKLEPKLVPLVIAFRYWAKLCSIDCPEEGGLPPYVFALMAVFFLQQRKEPLLP ****: ******:*:*************:** ***********.***:************ ENSMUSP00000071623/1-1474 VYLGSWIEEFSLNKLGNFSLKDVEKDSVVWEYTDNSTGDTSSAKEEAPKETAAKKGQVPL ENSRNOP00000022373/1-1485 VYLGSWIEEFSLNKLGNFSLKDVEKDSVVWEYTDNSTGDTSSPKEEALRETAAKKGQVPL ENSP00000365130/1-1495 VYLGSWIEGFSLSKLGNFNLQDIEKDVVIWEHTDSAAGDTGITKEEAPRETPIKRGQVSL ENSCPOP00000002278/1-1465 VYLGSWIEGFSLKKLGNFNLKDVEEDFVIWEYTENAAGDANTAKEEAPKEMPVRRGQVSL XP_004862523.1/1-1503 VYLGSWVDGFSLNKLGNFNLKAIEDDSVIWEYTSNAAGDTNAAKEEAPKEMPVRRGQVSL ******:: ***.*****.*: :*.* *:**:*..::**:. .**** :* . ::***.* ENSMUSP00000071623/1-1474 TFNIKHQPSVPVGQLWVELLRFYALEFNLADLVISIRVKELISRESKDWPKKRIAIE--D ENSRNOP00000022373/1-1485 TFNIKHQPSVPVGQLWVELLRFYALEFNLADLVISIRVKELISRESKDWPKKRIAIE--D ENSP00000365130/1-1495 ILDVKHQPSVPVGQLWVELLRFYALEFNLADLVISIRVKELVSRELKDWPKKRIAIE--D ENSCPOP00000002278/1-1465 MFDIKHEPSVPVGQLWVELLRFYALEFNLADLVISIRVKESISRESKDWPKKRIAIEVTD XP_004862523.1/1-1503 TFEVKHQPSVPVGQLWVELLRFYALEFNLADLVISIRVKESISRESKDWPKKRIAIE--D :::**:********************************* :*** *********** * ENSMUSP00000071623/1-1474 PYSVKRNVARTLNNQPVFEYILHCLRTTYKYFALPHKVTKPNLTKPPSPVTCVSDPYREA ENSRNOP00000022373/1-1485 PYSVKRNVARTLNNQPVFEYILHCLRTTYKYFALPHKVTKPNLTKPPSPIICASDPYKEA ENSP00000365130/1-1495 PYSVKRNVARTLNSQPVFEYILHCLRTTYKYFALPHKITKSSLLKPLNAITCISEHSKEV ENSCPOP00000002278/1-1465 PYSVKRNVARTLNNQPVFEYILHCLRTTYKYFALPHKVGKSSLPKPLSPVSCVSEHSKEV XP_004862523.1/1-1503 PYSVKRNVARTLNNQPVFEYILHCLRTTYKYFALPHKVGKSSLPKPLSPVSCISEHSKEV *************.***********************: *..* ** ..: * *: :*. ENSMUSP00000071623/1-1474 KNGGPEPQATNIDKLGNAAVAQDPGV---QTSGDCRAQLVTLKNTTEEVGSPAKEKTGGV ENSRNOP00000022373/1-1485 KNCGPELQVTNIDKLENALVAPDPGV---QTSGSCRAQPLTFKKTTEELGSPSKETIRGV ENSP00000365130/1-1495 INHHPDVQTKD-DKLKNSVLAQGPGA-TSSAANTCKVQPLTLKETAESFGSPPKEEMGNE ENSCPOP00000002278/1-1465 VNYDPGIQAKD-DNRKNSVLAQSPGATTTSTTNTQKAQPLSLKEMMKSFGIPPAEEMGKE XP_004862523.1/1-1503 VNYDPDVQPKD-DKLRNSVLTQSPGATTTSTANTGKTQPLSLKEMTKSFGSLPAEEVGND * * * .: *: *: :: .**. .::. :.* :::*: :..* . * ENSMUSP00000071623/1-1474 HIPAHQESSGCVQAEVSCEGLEDATAELPETGSDN--EEVRRKTKHPLSTDDQGLSSSKH ENSRNOP00000022373/1-1485 HIPVHQESSGCVQAEASYEGFKDATAEQQEAGSDS--ENSRRKTKHLLSTDDQGLSSSKH ENSP00000365130/1-1495 HISVHPENSDCIQADVNSDDYKGDKVYHPETGRKNEKEKVGRKGKHLLTVD------QKR ENSCPOP00000002278/1-1465 HSSTHNEDTSCVRAQI-------------ERGSKNEKEKIRREGNC-------------- XP_004862523.1/1-1503 HITICLEDSSCDQGQV-------------ERGSKNEKEKIEKEGKCPLTTHVQSLSSSKY * . *.:.* :.: * * .. *: :: : ENSMUSP00000071623/1-1474 PELQNCGSLCGLQADNTLEL------VAEECNSCASLDNKAEVNEERIEGAEELEEAAAL ENSRNOP00000022373/1-1485 PELQNCGSLCGLQADNTLEL------VAEKCSSFASLDDKADVNERSTEGADERGE--AL ENSP00000365130/1-1495 GEHVVCGSTRNNESESTLDLEGFQNPTAKECEGLATLDNKADLDGESTEGTEELED--SL ENSCPOP00000002278/1-1465 GELEACGSAHNDKAGGALQLDTLQNPVAEKSDGFTILDDKVN-DEESVEGTREPEV--SV XP_004862523.1/1-1503 GELVACGSTHIYETDGALELEDLQNPMGKKCDGFSTLDGKTN-VEESIEGASELED--SV * *** :: .:*:* .::... : **.*.: . **: * :: ENSMUSP00000071623/1-1474 SCFSPSVQSRTSAAMHFDDEEEEEEEEEEEE----------------PRLSINLTEDEEG ENSRNOP00000022373/1-1485 NCFSPSVQSCTSATMHFDEEEEEEEEEEEEE----------------PRLRTNLTEDEEG ENSP00000365130/1-1495 NHFTHSVQGQTSEMIPSDEEEEDDEEEEEEEE---------------PRLTINQREDEDG ENSCPOP00000002278/1-1465 NHIATLIQGQTSEIIQFDEEEVEKE----------------------PGFTINQREVEGD XP_004862523.1/1-1503 DYIAPLIQGQTSEINPFDEEEEEDEEEEEEEEEEEEEEEEEEEEEEPPRLTINRGEAEDG . :: :*. ** *:** :.* * : * * * . ENSMUSP00000071623/1-1474 VANEHQVDSRYAGSGEEDALSEE--DDLAEPAKGEDTGECGENVGGTLLIDLNRITLKEE ENSRNOP00000022373/1-1485 VASENQVDSRYTGSG-EDALSED--DDLAEPAKGEDLEESGEHMGGALLIDLNRITLKEE ENSP00000365130/1-1495 MANEDELDNTYTGSGDEDALSEED-DELGEAAKYEDVKECGKHVERALLVELNKISLKEE ENSCPOP00000002278/1-1465 IANEDELDNSCTGSGDEDALSEEE-DELVNPTKYEDLKECEKYVDGALLMELNKINLTAE XP_004862523.1/1-1503 TANEDEFGNTYAGSGDEDAQSEEEDDELVGPTNHEDLKECGKHVDGALLMELNKINLKGE *.*.:... :*** *** **: *:* .:: ** *. : : :**::**:*.*. * ENSMUSP00000071623/1-1474 SF-PEEDLPGDQSEFFYEFRKLTFTKGKSPTVVCSLCKREGHLKKDCPEDFKRVQLEPLP ENSRNOP00000022373/1-1485 SF-FEENSPGDQSEFFYEFRKLTFTKGKSPTVVCSLCKREGHLKKDCPEDFKRIQLEPLP ENSP00000365130/1-1495 NVCEEKNSPVDQSDFFYEFSKLIFTKGKSPTVVCSLCKREGHLKKDCPEDFKRIQLEPLP ENSCPOP00000002278/1-1465 NV-QEENSPVDQSDFIYEFSKLIFTKGKSPTVVCNLCKREGHLKKDCPEDFRRIQLEPLP XP_004862523.1/1-1503 KA-QEENSPVDQSDFIYEFSKLIFTKGKSPTVVCNLCKREGHLKKDCPEDFKRIQLEPLP . *:: * ***:*:*** ** ***********.****************:*:****** ENSMUSP00000071623/1-1474 PLTPKFSNILDQVCVQCYKDFSPTIVEDQAREHIRQNLESFIKQDFPGTKLSLFGSSKNG ENSRNOP00000022373/1-1485 PLTPKFSNILDQVCIQCYKDFSPTIVEDQAREHIRQNLESFIKQDFPGTKLSLFGSSKNG ENSP00000365130/1-1495 PLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQDFPGTKLSLFGSSKNG ENSCPOP00000002278/1-1465 PLTPKFSYILDQVCIQCYKDFSPNALEEQAREHIRQNLESFIRQDFPGTKLSLFGSSKNG XP_004862523.1/1-1503 PLTPKFSYILDQVCIQCYKDFSPSTSEEQAREHIRQNLESFIRQDFPGTKLSLFGSSKNG ****** ******:********. *:**************:***************** ENSMUSP00000071623/1-1474 FGFKQSDLDVCMTINGHETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFFH ENSRNOP00000022373/1-1485 FGFKQSDLDVCMTINGHETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFSH ENSP00000365130/1-1495 FGFKQSDLDVCMTINGLETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFFH ENSCPOP00000002278/1-1465 FGFKQSDLDICMTINGHETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFFH XP_004862523.1/1-1503 FGFKQSDLDVCMTINGHETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFFH *********:****** ***************************************** * ENSMUSP00000071623/1-1474 LRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSY ENSRNOP00000022373/1-1485 LRSGLEVDISLYNTLALHNTRLLFAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSY ENSP00000365130/1-1495 LRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSY ENSCPOP00000002278/1-1465 LRSGLEVDISLYNTLALHNTRLLSAYSAIDLRVKYLCYTMKVFTKMCDIGDASRGSLSSY XP_004862523.1/1-1503 LRSGLEVDISLYNTLALHNTRLLCAYSAIDLRVKYLCYTMKVFTKMCDIGDASRGSLSSY *********************** ****** ***************************** ENSMUSP00000071623/1-1474 AYTLMVLYFLQQRSPPVIPVLQEIYKGEKKPEILVDGWNIYFFDQINELPTCWPEYGKNT ENSRNOP00000022373/1-1485 AYTLMVLYFLQQRSPPVIPVLQEIYKGEKKPEILVDGWNIYFFDQINELPTCWPEYGKNT ENSP00000365130/1-1495 AYTLMVLYFLQQRNPPVIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNT ENSCPOP00000002278/1-1465 AYTLMVLYFLQQRSPPVIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWPEYGKNT XP_004862523.1/1-1503 AYTLMVLYFLQQRSPPVIPVLQEIYRGEKKPEIFVDGWNIYFFDQIDELPTYWPEYGKNT *************.***********:*******:************:**** *.* **** ENSMUSP00000071623/1-1474 EPVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHNLGAG ENSRNOP00000022373/1-1485 ESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHNLGAG ENSP00000365130/1-1495 ESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHNLGAG ENSCPOP00000002278/1-1465 ESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEPPWDKNHNLGAG XP_004862523.1/1-1503 ESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHNLGAG *.********************************************** *:* ******* ENSMUSP00000071623/1-1474 LSRKMTNFIMKAFINGRRVFGIPVKGFPKDNPSKLAYFFDPDVLTEGELAPNDRCCRICG ENSRNOP00000022373/1-1485 LSRKMTNFIMKAFINGRRVFGIPVKGFPKDI---LAYFFDPDVLTEGELAPNDRCCRICG ENSP00000365130/1-1495 LSRKMTNFIMKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDVLTEGELAPNDRCCRICG ENSCPOP00000002278/1-1465 LSRKMTNFIMKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDVLTEGELAPNDRCCRICG XP_004862523.1/1-1503 LSRKMTNFIMKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDVLTEGELAPNDRCCRICG ****************************** : ************************ ENSMUSP00000071623/1-1474 KIGHFMKDCPMRRKVRRRRDQEDTPNQRYSESKEKRSKEDKEIQNKYTEKEVSTKEDKLT ENSRNOP00000022373/1-1485 KIGHFMKDCPMRRKVRRRRDQEDTPNQRYTESKEKRSKEDKEIQNKYTEKEVSAKEDKAA ENSP00000365130/1-1495 KIGHFMKDCPMRRKVRRRRDQEDALNQRYPENKEKRSKEDKEIHNKYTEREVSTKEDKPI ENSCPOP00000002278/1-1465 KIGHFMKDCPMRRKVRRRQNQEDTLHQRYAENKDKKSKEEKDIQNKHTEKETSAREDKPV XP_004862523.1/1-1503 KIGHFMKDCPMRRKVRRRRNQEDTLHQRYPENKDKKSKEEKEIQNKYAEREVSAKEDKSV ******************::***: :***.*.*:*:***:*:*:**::*:*.*::*** ENSMUSP00000071623/1-1474 PCAAAKAKPVRAAVDLGREKLLRTPTEKWKRQDDRDSREKRCFICGREGHIKKECPQFKG ENSRNOP00000022373/1-1485 PCTAAKAKPMRAAVDLGREKLVRTPAEKWKRQDDRDSREKRCFICGREGHIKKECPQFKG ENSP00000365130/1-1495 QCTPQKAKPMRAAADLGREKILRPPVEKWKRQDDKDLREKRCFICGREGHIKKECPQFKG ENSCPOP00000002278/1-1465 PCVAQKAKMARVAADPGREKMLRPLVERWKRQDSTDFREKRCFICGREGHIRKECPQFKG XP_004862523.1/1-1503 PCAAQKAKTVRAAVDPGREKILRPLMEKWKRQDNKDLREKCCFICGREGHIRKECPQLKV *.. *** *.*.* ****::*. *:*****. * *** **********:*****:* ENSMUSP00000071623/1-1474 SPGSAFT----------------- ENSRNOP00000022373/1-1485 SPGSLSSKYMTQGRASVKRTQQES ENSP00000365130/1-1495 SSGSLSSKYMTQGKASAKRTQQES ENSCPOP00000002278/1-1465 SPGSLSSKSMTQGKASAKRSPQES XP_004862523.1/1-1503 SAGSLSSKYTTQGKASAKRSPQES *.** :