CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000049977/1-1233 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLA ENSRNOP00000015496/1-1203 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLA ENSP00000358770/1-1235 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA ENSCPOP00000000892/1-1232 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLA XP_004866552.1/1-1240 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLA *******************************:************************.*** ENSMUSP00000049977/1-1233 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNL-WILIEFCAGGAVDAV ENSRNOP00000015496/1-1203 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNL-WILIEFCAGGAVDAV ENSP00000358770/1-1235 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNL-WILIEFCAGGAVDAV ENSCPOP00000000892/1-1232 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWWILIEFCAGGAVDAV XP_004866552.1/1-1240 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNL-WILIEFCAGGAVDAV ******************************************** *************** ENSMUSP00000049977/1-1233 MLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK ENSRNOP00000015496/1-1203 MLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK ENSP00000358770/1-1235 MLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK ENSCPOP00000000892/1-1232 MLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK XP_004866552.1/1-1240 MLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK *********************:************************************** ENSMUSP00000049977/1-1233 NTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELN ENSRNOP00000015496/1-1203 NTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELN ENSP00000358770/1-1235 NTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELN ENSCPOP00000000892/1-1232 NTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELN XP_004866552.1/1-1240 NTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELN ************************************************************ ENSMUSP00000049977/1-1233 PMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFVTVDSNKP ENSRNOP00000015496/1-1203 PMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKP ENSP00000358770/1-1235 PMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKP ENSCPOP00000000892/1-1232 PMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTIDSNKP XP_004866552.1/1-1240 PMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTIDSNKP ********************:*********:***********************:***** ENSMUSP00000049977/1-1233 VRELIAEAKAEVTEEVEDGKEEDEEEEAENALPIPANKRASSDLSIASSEEDKLSQNACI ENSRNOP00000015496/1-1203 VRELIAEAKAEVTEEVEDGKEEDDDDETESALPIPANKRASSDLSIASSEEDKLSQNACI ENSP00000358770/1-1235 IRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACI ENSCPOP00000000892/1-1232 IRELIAEAKAEVTEEVEDGKEEDDDEEIENSLPIPTNKRASSDLSIASSEEDKLSQNACI XP_004866552.1/1-1240 VRELIAEAKAEVTEEVEDGKEEDDDEEIENSLPIPTNKRASSDLSIASSEEDKLSQNACI :**********************:::* *.:****:.*********************** ENSMUSP00000049977/1-1233 LESVSERTEQSTSEDKFSNKILNEKPTTDGPEKAVD---EHASDVNLETGAELNDQTVGI ENSRNOP00000015496/1-1203 LESVSERTEHNTSGDKFSNKVLSEKPTPEGPEKAVD-VDGPANDVNLETVAEPNDQAVGF ENSP00000358770/1-1235 LESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVI ENSCPOP00000000892/1-1232 LESVSEKTEHNASGDKFSTKVLNEKPCPGEPENAVELVGG--------AVAVLPDRATEL XP_004866552.1/1-1240 LESVSEKTEHNASGDKFSSKVLNEKSCTD--EKTVEGVEEHGNDARSEVAAELPNPTTVP ******:**:. * **:..*:*.**. . *::*: . : : :. ENSMUSP00000049977/1-1233 HENGREKKRPKLENLPDTQDQQTVDVNSVSEENENNR-VTLETNTDC-LKPEEDRNKENQ ENSRNOP00000015496/1-1203 HENGREKKRPKLESQPDTEDQQTVDVNLVGEGNDSNI-VILETNTDC-LKPEEDRNEENQ ENSP00000358770/1-1235 KENER-EKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQ ENSCPOP00000000892/1-1232 PESGREEKRPKLDRLPDTEDQEMADINSVSEGEEDHA-VTSETNIEHNLKPEKERDQEKQ XP_004866552.1/1-1240 QEDGRTEKRPKLDDLSDMEDQEMVDIDLASEGKGNNT-DAVETNIKRNLKPEEERDQEKQ *. * :*****: .* :**: .*:: ..* : .: *** . **.*:::::*:* ENSMUSP00000049977/1-1233 ETLESKLIQSEEINDTHIQTMDLVSQETGEKEADFQAVDNEVGLTKEETQEKLGKDGTAQ ENSRNOP00000015496/1-1203 EIIENKLTQSEEIKDIHIQTMDLVSQETGEKEADFQAIDNEVGFTKEETQEKLGKDDKTQ ENSP00000358770/1-1235 QMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQ ENSCPOP00000000892/1-1232 PVLENKLVKSE---DTTIQTVDLVSQETGEKEVDIHILDSEVVHAVEDTHEKLRKDDTTQ XP_004866552.1/1-1240 QLLENKPVRSENSKDTTIQTGDLVSEETGEKEADIRIIDSGVLHTKEDTQEKLGKDDKTQ :*.* :** * :** ****:******.::: :*. * : *:*:*** :*..:* ENSMUSP00000049977/1-1233 KVITSDRSSEVGTDEALDDTQKAAELS-KAAQSGEGDEALAPTQTLAEKPTEGPEAGGAE ENSRNOP00000015496/1-1203 KVVISDISSEVGTDEAPGDTQKAAEQS-QDAEGGAGEEAPEPAQTLTEKATEGPEAHGAE ENSP00000358770/1-1235 KDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTK ENSCPOP00000000892/1-1232 KDVISDTSSVGERDEEIGAVPKTAESSAEGAQGDGGKETDEGAQILISKATEGPKASGTE XP_004866552.1/1-1240 NDVISDTSNVVERNEDVGVAQKAVENSTLDVQSNDGKDALEVAQKLINEVTHSPEADGTG : : *: *. * . . *. * * .:.. *.:. * * .: .*:* *: ENSMUSP00000049977/1-1233 EEPPGGERVEDKQPEQQPAVCEAEGQLTSTSETTRATLEQPETDEVEQVSESNSIEELE- ENSRNOP00000015496/1-1203 EEPRSGERVEDKQLEQQSAVCEGEGQVTSTSESTRATTEEPETDEVDQVSESNSIEELE- ENSP00000358770/1-1235 EVP-IKEIVEMNEIE----EGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEV ENSCPOP00000000892/1-1232 EAPPVTEITETNDTDQKLVENTHEKQLPISSETTLDTSEGLGASEGREVTESGSTEEVEV XP_004866552.1/1-1240 EVPSVTEIVATNDIDKKFVENKYEKQLINNSENILDNSEETGTNEVEEVTESSSTEEIEV * * * . :: : : * .**. * : * :::**.* **:* ENSMUSP00000049977/1-1233 RLVVTGAEARALGSEGEAA---ATEVDLERKENAQKVPVKAESQAPAASQPSEPHPVLIP ENSRNOP00000015496/1-1203 RLGVTGAEEQALGSKGEAA----TEVDLEREENAQELPIKAEPQAPAASQPSEPPPVLIP ENSP00000358770/1-1235 RSVVADTDQKALGSEVQDASKVTTQIDKEKKEIP--VSIKKEPEVTVVSQPTEPQPVLIP ENSCPOP00000000892/1-1232 EGAVSETDEEDVQSETRGAPMAVTQMDTEKNETPHEAPAQVEVQVPVPPQPSEPPPAPIP XP_004866552.1/1-1240 RSTVIDTDEETIGSETQDAHKAITQLDTEQKEIAYEVPAKTEPQVPAASQPGEPQPVPVP . * :: . : *: . * *::* *::* . . : * :... .** ** *. :* ENSMUSP00000049977/1-1233 SININSETTENKEEMGALPKPETILPPEPEHEKGNDTDSGTGSTVENSSGDLNLSISSFL ENSRNOP00000015496/1-1203 SINIHSENTENKGEMGALPKPETILPPEPENGKGNDTDSGTGSTVENSSSDLNLSISSFL ENSP00000358770/1-1235 SININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFL ENSCPOP00000000892/1-1232 SININSEAAENKGEMGASLNTETILLPESESQKENDTDSGTGSTADNSSIDLNLSISSFL XP_004866552.1/1-1240 SININSEDTENKGEIGALSKTETILLPESENQKENDTDSGTGSTADNSSIDLNLSISSFL ****:*: *** *:*: :.**** **.* * **.*******.:.** ********** ENSMUSP00000049977/1-1233 SKAKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQEL ENSRNOP00000015496/1-1203 SKTKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQEL ENSP00000358770/1-1235 SKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQEL ENSCPOP00000000892/1-1232 SKTKDNGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQEL XP_004866552.1/1-1240 SKTKDTGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVSDSDSKTEELRFLRRQEL **:**.**:*********************************:***************** ENSMUSP00000049977/1-1233 RELRLLQKEEQRAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIER ENSRNOP00000015496/1-1203 RELRLLQKEEQKAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIER ENSP00000358770/1-1235 RELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIER ENSCPOP00000000892/1-1232 RELRFLQKEEQRAQQQLNGKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIER XP_004866552.1/1-1240 RELRFLQKEEQRAQQQLNGKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIER ****:******:******.*****************:*********************** ENSMUSP00000049977/1-1233 LEQEHTNRLRDEAKRIKGEQEKELSKFQNVLKNRKKEVMNEVEKAPRELRRELTKRRKEE ENSRNOP00000015496/1-1203 LEQEHTNRLRDEAKRIKGEQEKELSKFQNMLRNRKKE----------------------- ENSP00000358770/1-1235 LEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEE ENSCPOP00000000892/1-1232 LEQEHTNRLRDEAKRIKGEQEKELSKFQNILKNRKKEVLNEVEKAPKDLRKELMKRRKEE XP_004866552.1/1-1240 LEQEHTNRLRDEAKRIKGEQEKELSKFQNILKNRKKEVLNEVEKAPKDLRKELMKRRREE *****************************:*:***** ENSMUSP00000049977/1-1233 LAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWEL ENSRNOP00000015496/1-1203 --------EQEFVQKQQQELDGALKKIIQQQKAELANIERECLNNKQQLLRAREAAIWEL ENSP00000358770/1-1235 LAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWEL ENSCPOP00000000892/1-1232 LAQSQHVQEQDFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWEL XP_004866552.1/1-1240 LAQSQRVQEQDFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWEL **:***********:**************************:********** ENSMUSP00000049977/1-1233 EERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARL ENSRNOP00000015496/1-1203 EERHLQEKHQLLKQQLKDQYFIQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARL ENSP00000358770/1-1235 EERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARL ENSCPOP00000000892/1-1232 EERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARL XP_004866552.1/1-1240 EERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARL *********************:************************************** ENSMUSP00000049977/1-1233 PKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNERMAQHQKHESQM ENSRNOP00000015496/1-1203 PKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNERMAQHQKHESQM ENSP00000358770/1-1235 PKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQM ENSCPOP00000000892/1-1232 PKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFSAQEEKRQKNERMAQHQKHENQM XP_004866552.1/1-1240 PKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQM *******************************:*****:*******************.** ENSMUSP00000049977/1-1233 RDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEE ENSRNOP00000015496/1-1203 RDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEE ENSP00000358770/1-1235 RDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEE ENSCPOP00000000892/1-1232 RDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEE XP_004866552.1/1-1240 RDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEE ************************************************************ ENSMUSP00000049977/1-1233 EFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPIPTLHSTGS ENSRNOP00000015496/1-1203 EFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPIPTLHSTGS ENSP00000358770/1-1235 EFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS ENSCPOP00000000892/1-1232 EFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS XP_004866552.1/1-1240 EFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS *************************:***********:******