Sequence detailsNCBI ID: XM_004842229.1 (Coding sequence)  Best Hit

Details from NCBI annotation

Gene Symbol App
Gene Name amyloid beta (A4) precursor protein, transcript variant X2
Entrez Gene ID 101724743

This gene is present in the GenAge database and has been identified as potentially important to ageing in humans.

Database interlinks

Part of NW_004624745.1 (SequenceType object (1))

For more information consult the page for NW_004624745.1 (SequenceType object (1))

Potential Gene Matches

The following genes have been identified as possible homologs of the naked mole-rat gene and compared to it.

APPENSCPOG00000001427 (Guinea pig)

Gene Details

amyloid beta (A4) precursor protein

External Links

Gene Match(Ensembl Protein ID:ENSCPOP00000001291, Guinea pig)

Protein Percentage 97.66%
CDS Percentage 93.51%
Ka/Ks Ratio 0.0471 (Ka = 0.013, Ks = 0.2751)

APPENSG00000142192 (Human)

Gene Details

amyloid beta (A4) precursor protein

External Links

Gene Match(Ensembl Protein ID:ENSP00000284981, Human)

Protein Percentage 96.1%
CDS Percentage 90.48%
Ka/Ks Ratio 0.054 (Ka = 0.0218, Ks = 0.403)

AppENSMUSG00000022892 (Mouse)

Gene Details

amyloid beta (A4) precursor protein

External Links

Gene Match(Ensembl Protein ID:ENSMUSP00000005406, Mouse)

Protein Percentage 96.26%
CDS Percentage 88.54%
Ka/Ks Ratio 0.03406 (Ka = 0.0207, Ks = 0.6092)

AppENSRNOG00000006997 (Rat)

Gene Details

amyloid beta (A4) precursor protein (App), mRNA

External Links

Gene Match(Ensembl Protein ID:ENSRNOP00000041613, Rat)

Protein Percentage 96.23%
CDS Percentage 89.18%
Ka/Ks Ratio 0.03787 (Ka = 0.0208, Ks = 0.5504)

Genome Location

Sequence SequenceType object (2)

Length: 2313 bp    Location: 14108134..13904993   Strand: -
Raw sequence   
>XM_004842229.1
ATGCTGCCAGGCCTATCCCAGTTGTTGATTCTTTGTGCTAGTTCCCGAGCTACTGAGGTGCCCACTGATGGCAATGCTGGCCTGCTGGCGGAACCCCAGATCGCCATGTTCTGTGGGAAACTGAACATGCACATGAATGTGCAGAATGGGAAGTGGGAGCCGGATCCATCAGGGACCAAAACCTGCATCGGCAGCAAGGAGGGCATCCTGCAGTACTGCCAAGAGGTCTACCCTGAGCTGCAGATCACCAACGTGGTGGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGAGCCGCAAGCAGTGCAAGACCCACCCCCACTTCGTGATTCCTTACCGCTGCTTAGTTGGTGAGTTTGTAAGCGACGCCCTCCTCGTTCCTGACAAGTGCAAATTCCTACACCAGGAGCGGATGGATGTTTGTGAGACCCACCTTCACTGGCACACCGTTGCCAAAGAGACATGCAGCGAGAAGAGCACCAACTTGCATGACTATGGCATGTTGCTGCCCTGTGGAATCGACAAGTTCCGAGGGGTGGAGTTTGTATGCTGCCCACTGGCTGAAGAAAGTGACAATATTGATTCTGCTGACGCAGAAGAGGATGACTCAGATGTCTGGTGGGGCGGAGCGGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTTACAGAGGAGGAAGAAGTGGCTGATGTTGAGGAAGAAGAAGCCGATGATGACGAGGATGTGGAGGACGGTGATGAGGTAGAGGAGGAGCCGGAAGAACCCTATGAAGAAGCCACAGAGAAAACCACCAGCATAGCCACCACCACCACCACCACCACGGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCATGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTCACTGAAGGGAAGTGCGCCCCGTTCTTTTACGGCGGATGTGGAGGCAACAGGAACAACTTTGACACGGAAGAATACTGCATGGCGGTGTGTGGCAGCGTCATGTCCCAAAGTCTACTCAAGACTACCGGGGAACCTGTTTCCCAAGATCTTGTTAAACTTCCTACCACAGCAGCCAGCACCCCTGACGCCGTTGACAAGTATCTCGAGACGCCTGGGGATGAGAATGAGCATGCCCACTTCCAGAAAGCCAAAGAGAGGCTGGAGGCCAAGCACCGAGAGAGAATGTCCCAAGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCCAAGAACTTGCCCAAGGCTGATAAGAAGGCTGTGATTCAGCATTTCCAGGAGAAAGTGGAGTCCCTGGAGCAGGAAGCAGCCAATGAGAGGCAGCAGCTGGTGGAGACACACATGGCTAGAGTGGAAGCCATGCTCAACGACCGCCGCCGCCTGGCTCTGGAGAACTACATCACCGCCCTACAGGCTGTGCCTCCCCGGCCTCGTCATGTATTCAACATGCTGAAGAAGTACGTTCGTGCTGAGCAGAAAGACAGGCAGCACACTCTGAAGCATTTTGAACACGTGCGCATGGTGGATCCCAAGAAGGCTGCACAGATCCGATCCCAGGTTATGACACACCTCCGTGTGATCTATGAGCGCATGAACCAGTCTCTCTCCCTGCTCTACAACGTCCCTGCCGTGGCTGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAGAACTACTCAGATGATGTCTTGGCCAACATGATCAGTGAACCAAGAATCAGTTATGGAAATGATGCTCTTATGCCCTCTTTGACTGAAACAAAAACCACCGTGGAGCTCCTCCCTGTGAATGGAGAATTTAGCCTGGATGATCTGCAGCCATGGCATCCTTTCGGGGTAGACTCTGTGCCAGCCAATACAGAGAATGAAGTGGAGCCTGTTGACGCTCGTCCAGCAGCCGACCGAGGACTGACCACTCGACCAGGTTCCGGGTTGACAAATATCAAGACAGAAGAGATCTCAGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGGTATGAAGTCCGTCATCAAAAATTGGTGTTCTTTGCAGAAGACGTGGGTTCAAACAAAGGTGCAATTATTGGACTCATGGTAGGCGGTGTTGTCATAGCAACAGTGATTGTCATCACCTTGGTGATGCTGAAGAAGAAACAATACACGTCCATCCATCATGGTGTGGTGGAGGTTGACGCTGCTGTGACCCCCGAAGAGCGCCACCTCTCCAAGATGCAACAGAACGGCTATGAGAATCCAACTTACAAGTTCTTTGAGCAGATGCAGAACTAG

Related Sequences

XP_004842286.1 SequenceType object (4)

App PREDICTED: amyloid beta A4 protein isoform X2 [Heterocephalus glaber]

Length: 770 aa      View alignments
>XP_004842286.1
MLPGLSQLLILCASSRATEVPTDGNAGLLAEPQIAMFCGKLNMHMNVQNGKWEPDPSGTKTCIGSKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRSRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNIDSADAEEDDSDVWWGGADTDYADGSEDKVVEVTEEEEVADVEEEEADDDEDVEDGDEVEEEPEEPYEEATEKTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVMSQSLLKTTGEPVSQDLVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN